The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at... See more...

Aliases for SERPINB1 Gene

Aliases for SERPINB1 Gene

  • Serpin Family B Member 1 2 3 5
  • PI2 2 3 4
  • EI 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 1 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 2 3
  • Leukocyte Elastase Inhibitor 3 4
  • Peptidase Inhibitor 2 3 4
  • ELANH2 3 4
  • M/NEI 3 4
  • MNEI 3 4
  • PI-2 3 4
  • LEI 3 4
  • Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived 3
  • Monocyte/Neutrophil Elastase Inhibitor 4
  • Epididymis Secretory Protein Li 27 3
  • Epididymis Luminal Protein 57 3
  • Anti-Elastase 2
  • Serpin B1 4
  • HEL-S-27 3
  • SERPINB1 5
  • HEL57 3

External Ids for SERPINB1 Gene

Previous HGNC Symbols for SERPINB1 Gene

  • ELANH2

Previous GeneCards Identifiers for SERPINB1 Gene

  • GC06M002817
  • GC06M002778
  • GC06M002707

Summaries for SERPINB1 Gene

Entrez Gene Summary for SERPINB1 Gene

  • The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for SERPINB1 Gene

SERPINB1 (Serpin Family B Member 1) is a Protein Coding gene. Diseases associated with SERPINB1 include Pulmonary Emphysema and Impetigo Herpetiformis. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB8.

UniProtKB/Swiss-Prot Summary for SERPINB1 Gene

  • Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).

Gene Wiki entry for SERPINB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB1 Gene

Genomics for SERPINB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERPINB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB1

Top Transcription factor binding sites by QIAGEN in the SERPINB1 gene promoter:
  • CUTL1
  • NF-AT4
  • POU2F1
  • POU2F1a
  • STAT3
  • TBP

Genomic Locations for SERPINB1 Gene

Latest Assembly
chr6:2,832,332-2,842,012
(GRCh38/hg38)
Size:
9,681 bases
Orientation:
Minus strand

Previous Assembly
chr6:2,832,566-2,842,097
(GRCh37/hg19 by Entrez Gene)
Size:
9,532 bases
Orientation:
Minus strand

chr6:2,832,566-2,842,240
(GRCh37/hg19 by Ensembl)
Size:
9,675 bases
Orientation:
Minus strand

Genomic View for SERPINB1 Gene

Genes around SERPINB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB1 Gene

Proteins for SERPINB1 Gene

  • Protein details for SERPINB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30740-ILEU_HUMAN
    Recommended name:
    Leukocyte elastase inhibitor
    Protein Accession:
    P30740
    Secondary Accessions:
    • A8K5L2
    • B4DNT0
    • Q53FB9
    • Q5W0E1
    • Q9UDF8

    Protein attributes for SERPINB1 Gene

    Size:
    379 amino acids
    Molecular mass:
    42742 Da
    Quaternary structure:
    • Monomer (PubMed:23269243). Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases (PubMed:30692621). Interacts with PRTN3 (PubMed:30692621). Interacts with GZMH (PubMed:23269243).
    SequenceCaution:
    • Sequence=BAD97090.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINB1 Gene

    Alternative splice isoforms for SERPINB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB1 Gene

Post-translational modifications for SERPINB1 Gene

  • Ubiquitination at Lys177 and Lys196
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINB1 Gene

No data available for DME Specific Peptides for SERPINB1 Gene

Domains & Families for SERPINB1 Gene

Gene Families for SERPINB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB1 Gene

Suggested Antigen Peptide Sequences for SERPINB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57130, highly similar to Leukocyte elastase inhibitor (B4DNT0_HUMAN)
  • cDNA FLJ53963, highly similar to Leukocyte elastase inhibitor (B4E3A8_HUMAN)
  • Serpin B1 (ILEU_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30740

UniProtKB/Swiss-Prot:

ILEU_HUMAN :
  • Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA.
  • Belongs to the serpin family. Ov-serpin subfamily.
Domain:
  • Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB1: view

Function for SERPINB1 Gene

Molecular function for SERPINB1 Gene

UniProtKB/Swiss-Prot Function:
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).

Phenotypes From GWAS Catalog for SERPINB1 Gene

Gene Ontology (GO) - Molecular Function for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA,NAS 1376927
GO:0005515 protein binding IPI 30692621
GO:0030414 peptidase inhibitor activity IEA,IDA 26701651
genes like me logo Genes that share ontologies with SERPINB1: view
genes like me logo Genes that share phenotypes with SERPINB1: view

Animal Models for SERPINB1 Gene

MGI Knock Outs for SERPINB1:

miRNA for SERPINB1 Gene

miRTarBase miRNAs that target SERPINB1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB1 Gene

Localization for SERPINB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB1 Gene

Secreted. Cytoplasm. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB1 gene
Compartment Confidence
extracellular 5
mitochondrion 3
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0016020 membrane HDA 19946888
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with SERPINB1: view

Pathways & Interactions for SERPINB1 Gene

PathCards logo

SuperPathways for SERPINB1 Gene

genes like me logo Genes that share pathways with SERPINB1: view

Pathways by source for SERPINB1 Gene

3 Reactome pathways for SERPINB1 Gene

Gene Ontology (GO) - Biological Process for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IDA 30692621
GO:0032691 negative regulation of interleukin-1 beta production IMP 30692621
GO:0043312 neutrophil degranulation TAS --
GO:0044342 type B pancreatic cell proliferation IDA 26701651
genes like me logo Genes that share ontologies with SERPINB1: view

No data available for SIGNOR curated interactions for SERPINB1 Gene

Drugs & Compounds for SERPINB1 Gene

(4) Drugs for SERPINB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SERPINB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB1: view

Transcripts for SERPINB1 Gene

mRNA/cDNA for SERPINB1 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB1

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7:
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - -
SP11:
SP12:
SP13: -
SP14: - - -

ExUns: 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for SERPINB1 Gene

GeneLoc Exon Structure for
SERPINB1

Expression for SERPINB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB1 Gene

This gene is overexpressed in Whole Blood (x14.2), Esophagus - Mucosa (x8.3), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for SERPINB1 Gene

This gene is overexpressed in Neutrophil (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINB1 Gene



Protein tissue co-expression partners for SERPINB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB1

SOURCE GeneReport for Unigene cluster for SERPINB1 Gene:

Hs.381167

mRNA Expression by UniProt/SwissProt for SERPINB1 Gene:

P30740-ILEU_HUMAN
Tissue specificity: In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.

Evidence on tissue expression from TISSUES for SERPINB1 Gene

  • Lung(4.8)
  • Intestine(4.7)
  • Blood(4.7)
  • Skin(4.5)
  • Nervous system(3.1)
  • Bone marrow(3)
  • Spleen(3)
  • Liver(2.8)
  • Pancreas(2.8)
  • Heart(2.7)
  • Stomach(2.7)
  • Kidney(2.5)
  • Lymph node(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with SERPINB1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB1 Gene

Orthologs for SERPINB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERPINB1 29 30
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SERPINB1 29 30
  • 82.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Serpinb1a 29
  • 82.23 (n)
Mouse
(Mus musculus)
Mammalia Serpinb1a 29 16 30
  • 81.44 (n)
OneToMany
Serpinb1b 30
  • 76 (a)
OneToMany
Serpinb1c 30
  • 72 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SERPINB1 29 30
  • 78.43 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 76 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia SERPINB1 30
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SERPINB1 30
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 65 (a)
OneToMany
-- 30
  • 60 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia serpinb1 29
  • 65.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25752 29
Zebrafish
(Danio rerio)
Actinopterygii serpinb1 29 30
  • 60.05 (n)
OneToMany
serpinb1l2 30
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Spn4 31
  • 36 (a)
Spn1 31
  • 35 (a)
Spn6 31
  • 35 (a)
CG9455 31
  • 34 (a)
CG6717 31
  • 33 (a)
CG9460 31
  • 33 (a)
Spn2 31
  • 33 (a)
Spn3 31
  • 33 (a)
Spn43Aa 31
  • 33 (a)
nec 31
  • 30 (a)
Spn5 31
  • 30 (a)
Spn43Ab 31
  • 29 (a)
CG7722 31
  • 28 (a)
CG6687 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea srp-6 31
  • 29 (a)
srp-7 31
  • 29 (a)
srp-1 31
  • 28 (a)
Species where no ortholog for SERPINB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SERPINB1 Gene

ENSEMBL:
Gene Tree for SERPINB1 (if available)
TreeFam:
Gene Tree for SERPINB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINB1: view image
Alliance of Genome Resources:
Additional Orthologs for SERPINB1

Paralogs for SERPINB1 Gene

genes like me logo Genes that share paralogs with SERPINB1: view

Variants for SERPINB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINB1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs115979952 Benign: not provided 2,833,880(-) G/A
NM_030666.4(SERPINB1):c.868C>T (p.Arg290Cys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs150564609 Benign: not provided 2,836,252(-) T/TA
NM_030666.4(SERPINB1):c.425-11dup
INTRON
rs34249702 Benign: not provided 2,840,548(-) C/T
NM_030666.4(SERPINB1):c.39G>A (p.Leu13=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs34825616 Benign: not provided 2,838,610(-) G/Ap.Ala82Val
NM_030666.4(SERPINB1):c.245C>T (p.Ala82Val)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINB1 Gene

Variant ID Type Subtype PubMed ID
nsv1124018 CNV deletion 24896259
nsv600831 CNV gain 21841781

Variation tolerance for SERPINB1 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB1
Leiden Open Variation Database (LOVD)
SERPINB1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB1 Gene

Disorders for SERPINB1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for SERPINB1 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SERPINB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB1 Gene

Publications for SERPINB1 Gene

  1. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. (PMID: 1376927) Remold-O'Donnell E … Alberts M (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4
  2. SERPINB1-mediated checkpoint of inflammatory caspase activation. (PMID: 30692621) Choi YJ … Jung JU (Nature immunology 2019) 3 4
  3. SerpinB1 Promotes Pancreatic β Cell Proliferation. (PMID: 26701651) El Ouaamari A … Kulkarni RN (Cell metabolism 2016) 3 4
  4. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. (PMID: 23269243) Wang L … Fan Z (Journal of immunology (Baltimore, Md. : 1950) 2013) 3 4
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3

Products for SERPINB1 Gene

Sources for SERPINB1 Gene