Aliases for SERPINA9 Gene

Aliases for SERPINA9 Gene

  • Serpin Family A Member 9 2 3 5
  • GCET1 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Germinal Center B-Cell-Expressed Transcript 1 Protein 3 4
  • SERPINA11b 2 3
  • SERPINA11 3 4
  • Serpin A9 3 4
  • Centerin 3 4
  • Serine Proteinase Inhibitor A11 3
  • SERPINA9 5
  • CENTERIN 2

External Ids for SERPINA9 Gene

Previous GeneCards Identifiers for SERPINA9 Gene

  • GC00U991020
  • GC14M092920
  • GC14M093998
  • GC14M094929
  • GC14M075109

Summaries for SERPINA9 Gene

GeneCards Summary for SERPINA9 Gene

SERPINA9 (Serpin Family A Member 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA7.

UniProtKB/Swiss-Prot Summary for SERPINA9 Gene

  • Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Wiki entry for SERPINA9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINA9 Gene

Genomics for SERPINA9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERPINA9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINA9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINA9

Top Transcription factor binding sites by QIAGEN in the SERPINA9 gene promoter:
  • AML1a
  • FOXF2
  • FOXO1
  • FOXO1a
  • IRF-7A
  • p53
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)

Genomic Locations for SERPINA9 Gene

Latest Assembly
chr14:94,462,717-94,479,689
(GRCh38/hg38)
Size:
16,973 bases
Orientation:
Minus strand

Previous Assembly
chr14:94,929,058-94,942,534
(GRCh37/hg19 by Entrez Gene)
Size:
13,477 bases
Orientation:
Minus strand

chr14:94,929,054-94,946,026
(GRCh37/hg19 by Ensembl)
Size:
16,973 bases
Orientation:
Minus strand

Genomic View for SERPINA9 Gene

Genes around SERPINA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA9 Gene

Proteins for SERPINA9 Gene

  • Protein details for SERPINA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WD7-SPA9_HUMAN
    Recommended name:
    Serpin A9
    Protein Accession:
    Q86WD7
    Secondary Accessions:
    • B4DVH4
    • B9ZVX3
    • Q2T9J2
    • Q6UWP9
    • Q86WD4
    • Q86WD5
    • Q86WD6
    • Q86YP6
    • Q86YP7

    Protein attributes for SERPINA9 Gene

    Size:
    417 amino acids
    Molecular mass:
    46557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO32345.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for SERPINA9 Gene

neXtProt entry for SERPINA9 Gene

Post-translational modifications for SERPINA9 Gene

  • Glycosylation at Asn101 and Asn390
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for SERPINA9

No data available for DME Specific Peptides for SERPINA9 Gene

Domains & Families for SERPINA9 Gene

Gene Families for SERPINA9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SERPINA9 Gene

Suggested Antigen Peptide Sequences for SERPINA9 Gene

GenScript: Design optimal peptide antigens:
  • Germinal center B-cell-expressed transcript 1 protein (SPA9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WD7

UniProtKB/Swiss-Prot:

SPA9_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA9: view

Function for SERPINA9 Gene

Molecular function for SERPINA9 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Phenotypes From GWAS Catalog for SERPINA9 Gene

Gene Ontology (GO) - Molecular Function for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA,IDA 15489334
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA9: view
genes like me logo Genes that share phenotypes with SERPINA9: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SERPINA9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINA9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA9 Gene

Localization for SERPINA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA9 Gene

[Isoform 1]: Secreted.
[Isoform 2]: Cytoplasm.
[Isoform 3]: Cytoplasm.
[Isoform 4]: Cytoplasm.
[Isoform 5]: Cytoplasm.
[Isoform 6]: Cytoplasm.
[Isoform 7]: Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 0
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINA9 Gene

Pathways & Interactions for SERPINA9 Gene

PathCards logo

SuperPathways for SERPINA9 Gene

No Data Available

Interacting Proteins for SERPINA9 Gene

Gene Ontology (GO) - Biological Process for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IBA 21873635
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA9 Gene

Drugs & Compounds for SERPINA9 Gene

No Compound Related Data Available

Transcripts for SERPINA9 Gene

mRNA/cDNA for SERPINA9 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINA9

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SERPINA9 Gene

GeneLoc Exon Structure for
SERPINA9

Expression for SERPINA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINA9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.0) and Skin - Sun Exposed (Lower leg) (x17.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINA9

SOURCE GeneReport for Unigene cluster for SERPINA9 Gene:

Hs.317970

mRNA Expression by UniProt/SwissProt for SERPINA9 Gene:

Q86WD7-SPA9_HUMAN
Tissue specificity: Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.

Evidence on tissue expression from TISSUES for SERPINA9 Gene

  • Blood(4.3)
  • Spleen(4.1)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with SERPINA9: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA9 Gene

Orthologs for SERPINA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERPINA9 30 31
  • 97.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SERPINA9 30 31
  • 81.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Serpina9 30
  • 76.87 (n)
Mouse
(Mus musculus)
Mammalia Serpina9 30 17 31
  • 74.84 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 48 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:174259 30
  • 49.77 (n)
Species where no ortholog for SERPINA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SERPINA9 Gene

ENSEMBL:
Gene Tree for SERPINA9 (if available)
TreeFam:
Gene Tree for SERPINA9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINA9: view image

Paralogs for SERPINA9 Gene

genes like me logo Genes that share paralogs with SERPINA9: view

Variants for SERPINA9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINA9 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs11628722 - p.Val330Ala
rs17090921 - p.Pro218Leu
rs28583900 - p.His236Gln
rs28618118 - p.Arg292Ile
rs4905204 - p.Ala24Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINA9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINA9 Gene

Variant ID Type Subtype PubMed ID
esv2760010 CNV loss 17122850
nsv1407 CNV insertion 18451855
nsv470662 CNV gain 18288195
nsv510649 CNV deletion 20534489
nsv565623 CNV gain 21841781
nsv832863 CNV gain 17160897
nsv832864 CNV loss 17160897

Variation tolerance for SERPINA9 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.03; 96.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA9 Gene

Disorders for SERPINA9 Gene

Additional Disease Information for SERPINA9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for SERPINA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINA9 Gene

Publications for SERPINA9 Gene

  1. Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. (PMID: 17898315) Montes-Moreno S … Piris MA (Blood 2008) 3 4 23
  2. Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas. (PMID: 18550480) Paterson MA … Coughlin PB (American journal of clinical pathology 2008) 3 4 23
  3. Molecular characterization of centerin, a germinal centre cell serpin. (PMID: 17447896) Paterson MA … Coughlin PB (The Biochemical journal 2007) 3 4 23
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41

Products for SERPINA9 Gene

Sources for SERPINA9 Gene