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Aliases for SERPINA9 Gene

Aliases for SERPINA9 Gene

  • Serpin Family A Member 9 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Germinal Center B-Cell-Expressed Transcript 1 Protein 3 4
  • SERPINA11 3 4
  • Centerin 3 4
  • GCET1 3 4
  • Serine Proteinase Inhibitor A11 3
  • SERPINA11b 3
  • Serpin A9 3

External Ids for SERPINA9 Gene

Previous GeneCards Identifiers for SERPINA9 Gene

  • GC00U991020
  • GC14M092920
  • GC14M093998
  • GC14M094929
  • GC14M075109

Summaries for SERPINA9 Gene

GeneCards Summary for SERPINA9 Gene

SERPINA9 (Serpin Family A Member 9) is a Protein Coding gene. Diseases associated with SERPINA9 include Ectopic Cushing Syndrome. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA7.

UniProtKB/Swiss-Prot for SERPINA9 Gene

  • Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Wiki entry for SERPINA9 Gene

Additional gene information for SERPINA9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA9 Gene

Genomics for SERPINA9 Gene

GeneHancer (GH) Regulatory Elements for SERPINA9 Gene

Promoters and enhancers for SERPINA9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094480 Enhancer 0.8 ENCODE 550.8 -1.9 -1863 1.3 FOXA2 MLX RAD21 THRB RARA MIXL1 EGR2 KLF11 MIER2 PPARG SERPINA9 SERPINA12
GH14I094476 Promoter 0.6 EPDnew 550.8 +3.5 3472 0.1 POLR2A SERPINA9 LOC105370635
GH14I094384 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +88.0 88047 15.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 SERPINA1 IFI27L2 SERPINA11 SERPINA9 ENSG00000256357 SERPINA2
GH14I094597 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -120.5 -120515 6.1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 SERPINA10 SERPINA3 SERPINA1 SERPINA5 SCARNA13 SNHG10 DICER1 SERPINA6 SERPINA11 SERPINA4
GH14I094580 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.3 -102.5 -102492 3.1 ELF3 NFIB MLX ARID4B DMAP1 THRB ZNF48 RAD21 RARA SLC30A9 SERPINA5 SERPINA9 ENSG00000273259
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINA9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINA9 gene promoter:

Genomic Locations for SERPINA9 Gene

Genomic Locations for SERPINA9 Gene
chr14:94,462,717-94,479,689
(GRCh38/hg38)
Size:
16,973 bases
Orientation:
Minus strand
chr14:94,929,054-94,946,026
(GRCh37/hg19)

Genomic View for SERPINA9 Gene

Genes around SERPINA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA9 Gene

Proteins for SERPINA9 Gene

  • Protein details for SERPINA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WD7-SPA9_HUMAN
    Recommended name:
    Serpin A9
    Protein Accession:
    Q86WD7
    Secondary Accessions:
    • B4DVH4
    • B9ZVX3
    • Q2T9J2
    • Q6UWP9
    • Q86WD4
    • Q86WD5
    • Q86WD6
    • Q86YP6
    • Q86YP7

    Protein attributes for SERPINA9 Gene

    Size:
    417 amino acids
    Molecular mass:
    46557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO32345.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SERPINA9 Gene

neXtProt entry for SERPINA9 Gene

Post-translational modifications for SERPINA9 Gene

  • Glycosylation at posLast=101101 and isoforms=2, 5, 6, 7390

No data available for DME Specific Peptides for SERPINA9 Gene

Domains & Families for SERPINA9 Gene

Gene Families for SERPINA9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SERPINA9 Gene

Suggested Antigen Peptide Sequences for SERPINA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WD7

UniProtKB/Swiss-Prot:

SPA9_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA9: view

Function for SERPINA9 Gene

Molecular function for SERPINA9 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Phenotypes From GWAS Catalog for SERPINA9 Gene

Gene Ontology (GO) - Molecular Function for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 15489334
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA9: view
genes like me logo Genes that share phenotypes with SERPINA9: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA9 Gene

Localization for SERPINA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA9 Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINA9 Gene

Pathways & Interactions for SERPINA9 Gene

SuperPathways for SERPINA9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA9 Gene

Drugs & Compounds for SERPINA9 Gene

No Compound Related Data Available

Transcripts for SERPINA9 Gene

Unigene Clusters for SERPINA9 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SERPINA9 Gene

GeneLoc Exon Structure for
SERPINA9
ECgene alternative splicing isoforms for
SERPINA9

Expression for SERPINA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINA9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.0) and Skin - Sun Exposed (Lower leg) (x17.8).

NURSA nuclear receptor signaling pathways regulating expression of SERPINA9 Gene:

SERPINA9

SOURCE GeneReport for Unigene cluster for SERPINA9 Gene:

Hs.317970

mRNA Expression by UniProt/SwissProt for SERPINA9 Gene:

Q86WD7-SPA9_HUMAN
Tissue specificity: Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.

Evidence on tissue expression from TISSUES for SERPINA9 Gene

  • Blood(4.2)
  • Spleen(4)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with SERPINA9: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA9 Gene

Orthologs for SERPINA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA9 33 34
  • 97.93 (n)
dog
(Canis familiaris)
Mammalia SERPINA9 33 34
  • 81.57 (n)
rat
(Rattus norvegicus)
Mammalia Serpina9 33
  • 76.87 (n)
mouse
(Mus musculus)
Mammalia Serpina9 33 16 34
  • 74.84 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:174259 33
  • 49.77 (n)
Species where no ortholog for SERPINA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA9 Gene

ENSEMBL:
Gene Tree for SERPINA9 (if available)
TreeFam:
Gene Tree for SERPINA9 (if available)

Paralogs for SERPINA9 Gene

Variants for SERPINA9 Gene

Sequence variations from dbSNP and Humsavar for SERPINA9 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000301804 -- 94,468,798(-) C/T intron_variant
rs1000455415 -- 94,463,531(-) A/C intron_variant
rs1000509602 -- 94,467,762(-) C/A intron_variant
rs1000584659 -- 94,473,546(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000638412 -- 94,473,311(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA9 Gene

Variant ID Type Subtype PubMed ID
nsv832864 CNV loss 17160897
nsv832863 CNV gain 17160897
nsv565623 CNV gain 21841781
nsv510649 CNV deletion 20534489
nsv470662 CNV gain 18288195
nsv1407 CNV insertion 18451855
esv2760010 CNV loss 17122850

Variation tolerance for SERPINA9 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.03; 96.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA9 Gene

Disorders for SERPINA9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERPINA9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ectopic cushing syndrome
  • cushing syndrome due to ectopic acth secretion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINA9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERPINA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINA9 Gene

Publications for SERPINA9 Gene

  1. Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas. (PMID: 18550480) Paterson MA … Coughlin PB (American journal of clinical pathology 2008) 3 4 22 58
  2. Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. (PMID: 17898315) Montes-Moreno S … Piris MA (Blood 2008) 3 4 22 58
  3. Molecular characterization of centerin, a germinal centre cell serpin. (PMID: 17447896) Paterson MA … Coughlin PB (The Biochemical journal 2007) 3 4 22 58
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58

Products for SERPINA9 Gene

Sources for SERPINA9 Gene

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