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SERPINA4 (Serpin Family A Member 4) is a Protein Coding gene. Diseases associated with SERPINA4 include Cerebral Hemisphere Lipoma and Corpus Callosum Lipoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004867 | serine-type endopeptidase inhibitor activity | TAS,IBA | 21873635 |
GO:0030414 | peptidase inhibitor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0031089 | platelet dense granule lumen | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002576 | platelet degranulation | TAS | -- |
GO:0010466 | negative regulation of peptidase activity | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | |||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SERPINA4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SERPINA4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Serpina4 30 |
|
||
Cow (Bos Taurus) |
Mammalia | SERPINA4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINA4 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs140563422 | Benign: not provided | 94,563,894(+) |
C/T NM_006215.4(SERPINA4):c.412C>T (p.Arg138Cys) |
MISSENSE | |
rs145967569 | Benign: not provided | 94,569,427(+) |
G/A NM_006215.4(SERPINA4):c.1116G>A (p.Glu372=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
cerebral hemisphere lipoma |
|
|
corpus callosum lipoma |
|
|
inflammatory bowel disease |
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