SERPINA11 Gene (Protein Coding)

Serpin Family A Member 11

GC14M094442
GIFtS:
34
See more...

Aliases for SERPINA11 Gene

Aliases for SERPINA11 Gene

  • Serpin Family A Member 11 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2 3
  • Serpin A11 3 4
  • Antiproteinase-Like 2 3
  • SERPINA11 5

External Ids for SERPINA11 Gene

Previous GeneCards Identifiers for SERPINA11 Gene

  • GC14U900167
  • GC14M092919
  • GC14M092899
  • GC14M093979
  • GC14M094908
  • GC14M075089

Summaries for SERPINA11 Gene

GeneCards Summary for SERPINA11 Gene

SERPINA11 (Serpin Family A Member 11) is a Protein Coding gene. Diseases associated with SERPINA11 include Pericardial Effusion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA1.

Additional gene information for SERPINA11 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINA11 Gene

Genomics for SERPINA11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SERPINA11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINA11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINA11

Top Transcription factor binding sites by QIAGEN in the SERPINA11 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • IRF-2
  • IRF-7A
  • p53

Genomic Locations for SERPINA11 Gene

Latest Assembly
chr14:94,442,438-94,452,857
(GRCh38/hg38)
Size:
10,420 bases
Orientation:
Minus strand

Previous Assembly
chr14:94,908,801-94,919,137
(GRCh37/hg19 by Entrez Gene)
Size:
10,337 bases
Orientation:
Minus strand

chr14:94,908,801-94,919,127
(GRCh37/hg19 by Ensembl)
Size:
10,327 bases
Orientation:
Minus strand

Genomic View for SERPINA11 Gene

Genes around SERPINA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SERPINA11 Gene

Proteins for SERPINA11 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SERPINA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U17-SPA11_HUMAN
    Recommended name:
    Serpin A11
    Protein Accession:
    Q86U17
    Secondary Accessions:
    • B2RV07

    Protein attributes for SERPINA11 Gene

    Size:
    422 amino acids
    Molecular mass:
    46989 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA11 Gene

Protein Expression for SERPINA11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SERPINA11 Gene

  • Glycosylation at Asn94, Asn106, Asn169, and Asn350

Other Protein References for SERPINA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINA11 Gene

Domains & Families for SERPINA11 Gene

Gene Families for SERPINA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SERPINA11 Gene

InterPro:
Blocks:
  • Serpin
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA11 Gene

GenScript: Design optimal peptide antigens:
  • Serpin A11 (SPA11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86U17

UniProtKB/Swiss-Prot:

SPA11_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA11: view

Function for SERPINA11 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for SERPINA11 Gene

Gene Ontology (GO) - Molecular Function for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA 21873635
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA11: view
genes like me logo Genes that share phenotypes with SERPINA11: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINA11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA11 Gene

Localization for SERPINA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA11 gene
Compartment Confidence
extracellular 4
mitochondrion 1
peroxisome 0
endoplasmic reticulum 0
cytosol 0
lysosome 0

Gene Ontology (GO) - Cellular Components for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINA11 Gene

Pathways & Interactions for SERPINA11 Gene

PathCards logo

SuperPathways for SERPINA11 Gene

No Data Available

Interacting Proteins for SERPINA11 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000335024 Q86U17-SPA11_HUMAN for SERPINA11 Gene via STRING IID

GPS-Prot Interaction Network for SERPINA11

Gene Ontology (GO) - Biological Process for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IBA 21873635
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA11 Gene

Drugs & Compounds for SERPINA11 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SERPINA11 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for SERPINA11 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINA11

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA11 Gene

No ASD Table

Relevant External Links for SERPINA11 Gene

GeneLoc Exon Structure for
SERPINA11

Expression for SERPINA11 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINA11 Gene

mRNA expression in normal human tissues for SERPINA11 Gene
mRNA expression by BioGPS for SERPINA11 GenemRNA expression by GTEx for SERPINA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for SERPINA11 Gene

This gene is overexpressed in Liver (x51.4).

Protein differential expression in normal tissues from HIPED for SERPINA11 Gene

This gene is overexpressed in Serum (59.7) and Plasma (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINA11 Gene



Protein tissue co-expression partners for SERPINA11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINA11

SOURCE GeneReport for Unigene cluster for SERPINA11 Gene:

Hs.145890

Evidence on tissue expression from TISSUES for SERPINA11 Gene

  • Liver(2.7)
genes like me logo Genes that share expression patterns with SERPINA11: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA11 Gene

Orthologs for SERPINA11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SERPINA11 31
  • 100 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SERPINA11 30 31
  • 84.6 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SERPINA11 30 31
  • 84.44 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Serpina11 30 17 31
  • 79.3 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Serpina11 30
  • 76.86 (n)
Oppossum
(Monodelphis domestica)
 Mammalia SERPINA11 31
  • 53 (a)
 OneToOne
Species where no ortholog for SERPINA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SERPINA11 Gene

ENSEMBL:
Gene Tree for SERPINA11 (if available)
TreeFam:
Gene Tree for SERPINA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINA11: view image

Paralogs for SERPINA11 Gene

Paralogs for SERPINA11 Gene

(26) SIMAP similar genes for SERPINA11 Gene using alignment to 1 proteins:

  • SPA11_HUMAN
genes like me logo Genes that share paralogs with SERPINA11: view

Variants for SERPINA11 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINA11 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs775643756 Likely Pathogenic: Pericardial effusion; Pleural effusion 94,446,576(-) G/T
NM_001080451.2(SERPINA11):c.672C>A (p.Tyr224Ter) 		NONSENSE
rs17752285 - p.Thr406Ser
rs1885137 - p.Glu230Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINA11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINA11 Gene

Variant ID Type Subtype PubMed ID
dgv1963n100 CNV gain 25217958
dgv674e212 CNV gain 25503493
nsv1407 CNV insertion 18451855
nsv470662 CNV gain 18288195
nsv510649 CNV deletion 20534489
nsv565623 CNV gain 21841781
nsv832863 CNV gain 17160897
nsv832864 CNV loss 17160897

Variation tolerance for SERPINA11 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA11 Gene

Disorders for SERPINA11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERPINA11 Gene - From: CVR and GCD

Disorder Aliases PubMed IDs
pericardial effusion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINA11

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SERPINA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINA11 Gene

Publications for SERPINA11 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3
  2. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu SJ … Fournier RE (Mammalian genome : official journal of the International Mammalian Genome Society 2004) 2 3
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Whole-exome sequencing analysis in twin sibling males with an anterior cruciate ligament rupture. (PMID: 27692106) Caso E … Guerado E (Injury 2016) 3
  5. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. (PMID: 24141781) Lin KT … Huang CY (Oncogene 2014) 3

ExternalLinks

View latest publications for SERPINA11 gene in Mastermind

Products for SERPINA11 Gene

Sources for SERPINA11 Gene