Aliases for SERP2 Gene

Aliases for SERP2 Gene

  • Stress Associated Endoplasmic Reticulum Protein Family Member 2 2 3 5
  • Stress-Associated Endoplasmic Reticulum Protein 2 3 4
  • Ribosome-Associated Membrane Protein RAMP4-2 3 4
  • C13orf21 3 4
  • Chromosome 13 Open Reading Frame 21 2
  • BA269C23.1 3

External Ids for SERP2 Gene

Previous HGNC Symbols for SERP2 Gene

  • C13orf21

Previous GeneCards Identifiers for SERP2 Gene

  • GC13P043845
  • GC13P044947
  • GC13P025749

Summaries for SERP2 Gene

GeneCards Summary for SERP2 Gene

SERP2 (Stress Associated Endoplasmic Reticulum Protein Family Member 2) is a Protein Coding gene. Diseases associated with SERP2 include Mixed Malaria. An important paralog of this gene is SERP1.

UniProtKB/Swiss-Prot Summary for SERP2 Gene

  • May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Additional gene information for SERP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERP2 Gene

Genomics for SERP2 Gene

GeneHancer (GH) Regulatory Elements for SERP2 Gene

Promoters and enhancers for SERP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERP2

Top Transcription factor binding sites by QIAGEN in the SERP2 gene promoter:
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hlf
  • LCR-F1
  • Pax-3
  • Pax-4a
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SERP2 Gene

Genomic Locations for SERP2 Gene
chr13:44,373,665-44,397,714
(GRCh38/hg38)
Size:
24,050 bases
Orientation:
Plus strand
chr13:44,947,801-44,971,850
(GRCh37/hg19)
Size:
24,050 bases
Orientation:
Plus strand

Genomic View for SERP2 Gene

Genes around SERP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP2 Gene

Proteins for SERP2 Gene

  • Protein details for SERP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6R1-SERP2_HUMAN
    Recommended name:
    Stress-associated endoplasmic reticulum protein 2
    Protein Accession:
    Q8N6R1

    Protein attributes for SERP2 Gene

    Size:
    65 amino acids
    Molecular mass:
    7431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERP2 Gene

Post-translational modifications for SERP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SERP2 Gene

Domains & Families for SERP2 Gene

Gene Families for SERP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SERP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERP2 Gene

GenScript: Design optimal peptide antigens:
  • Ribosome-associated membrane protein RAMP4-2 (SERP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6R1

UniProtKB/Swiss-Prot:

SERP2_HUMAN :
  • Belongs to the RAMP4 family.
Family:
  • Belongs to the RAMP4 family.
genes like me logo Genes that share domains with SERP2: view

Function for SERP2 Gene

Molecular function for SERP2 Gene

UniProtKB/Swiss-Prot Function:
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Phenotypes From GWAS Catalog for SERP2 Gene

Gene Ontology (GO) - Molecular Function for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERP2: view
genes like me logo Genes that share phenotypes with SERP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERP2 Gene

Localization for SERP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP2 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERP2 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1
cytoskeleton 0
nucleus 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERP2: view

Pathways & Interactions for SERP2 Gene

PathCards logo

SuperPathways for SERP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA 21873635
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA 21873635
genes like me logo Genes that share ontologies with SERP2: view

No data available for Pathways by source and SIGNOR curated interactions for SERP2 Gene

Drugs & Compounds for SERP2 Gene

No Compound Related Data Available

Transcripts for SERP2 Gene

mRNA/cDNA for SERP2 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SERP2 Gene

GeneLoc Exon Structure for
SERP2

Expression for SERP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERP2 Gene

mRNA differential expression in normal tissues according to GTEx for SERP2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SERP2 Gene

This gene is overexpressed in Fetal Brain (39.7) and Frontal cortex (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERP2 Gene



Protein tissue co-expression partners for SERP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERP2

SOURCE GeneReport for Unigene cluster for SERP2 Gene:

Hs.377972

Evidence on tissue expression from TISSUES for SERP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SERP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERP2 Gene

Orthologs for SERP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERP2 31 30
  • 98.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SERP2 31 30
  • 96.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Serp2 17 31 30
  • 95.38 (n)
cow
(Bos Taurus)
Mammalia SERP2 30
  • 94.36 (n)
rat
(Rattus norvegicus)
Mammalia Serp2 30
  • 92.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SERP2 31
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serp2 30
  • 87.18 (n)
zebrafish
(Danio rerio)
Actinopterygii serp2 31 30
  • 84.1 (n)
OneToMany
SERP2 (2 of 3) 31
  • 71 (a)
OneToMany
serp1 31
  • 64 (a)
OneToMany
wufc96h11 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10319 30
fruit fly
(Drosophila melanogaster)
Insecta CG32276 31
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59F4.2 31
  • 60 (a)
ManyToMany
T09A12.5 31
  • 54 (a)
ManyToMany
Species where no ortholog for SERP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP2 Gene

ENSEMBL:
Gene Tree for SERP2 (if available)
TreeFam:
Gene Tree for SERP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERP2: view image

Paralogs for SERP2 Gene

Paralogs for SERP2 Gene

(1) SIMAP similar genes for SERP2 Gene using alignment to 3 proteins:

  • SERP2_HUMAN
  • F2Z2S5_HUMAN
  • H7C5W3_HUMAN
genes like me logo Genes that share paralogs with SERP2: view

Variants for SERP2 Gene

Additional dbSNP identifiers (rs#s) for SERP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERP2 Gene

Variant ID Type Subtype PubMed ID
nsv1122813 CNV deletion 24896259

Variation tolerance for SERP2 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERP2 Gene

Disorders for SERP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed malaria
  • malaria by more than one parasite
- elite association - COSMIC cancer census association via MalaCards
Search SERP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SERP2

genes like me logo Genes that share disorders with SERP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERP2 Gene

Publications for SERP2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng JS … Lai CQ (PloS one 2013) 3 54

Products for SERP2 Gene

Sources for SERP2 Gene