Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERP2 Gene

Aliases for SERP2 Gene

  • Stress Associated Endoplasmic Reticulum Protein Family Member 2 2 3 5
  • Ribosome-Associated Membrane Protein RAMP4-2 3 4
  • C13orf21 3 4
  • Stress-Associated Endoplasmic Reticulum Protein 2 3
  • Chromosome 13 Open Reading Frame 21 2
  • BA269C23.1 3

External Ids for SERP2 Gene

Previous HGNC Symbols for SERP2 Gene

  • C13orf21

Previous GeneCards Identifiers for SERP2 Gene

  • GC13P043845
  • GC13P044947
  • GC13P025749

Summaries for SERP2 Gene

GeneCards Summary for SERP2 Gene

SERP2 (Stress Associated Endoplasmic Reticulum Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is SERP1.

UniProtKB/Swiss-Prot for SERP2 Gene

  • May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Additional gene information for SERP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERP2 Gene

Genomics for SERP2 Gene

GeneHancer (GH) Regulatory Elements for SERP2 Gene

Promoters and enhancers for SERP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I044373 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.4 360 1.2 ZBTB6 ZNF473 ZIC2 ZNF335 POLR2A ZBTB20 EZH2 ZNF202 SP3 MAZ LOC105370297 SERP2 TUSC8
GH13I044430 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.1 +60.9 60861 7.5 PKNOX1 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 ZNF48 YY1 PIR39989 TSC22D1 SERP2 ENSG00000225727 ENSG00000280357
GH13I044300 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -66.2 -66181 14.8 FOXA2 ZSCAN4 SIN3A BATF IRF4 BRCA1 RAD21 RFX5 YY1 ZNF335 SERP2 LACC1 GPALPP1 SMIM2 SMIM2-IT1 SMIM2-AS1 CCDC122 TSC22D1 GC13M044319 GC13M044260
GH13I044292 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17.6 -80.3 -80252 2.7 JUN HLF CEBPB CEBPG FOSL1 MITF JUND HNF4A SERP2 SMIM2-IT1 SMIM2 LACC1 CCDC122 GC13M044260 GC13M044319
GH13I044270 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -99.9 -99948 6.5 MEIS2 IRF2 ATF1 CEBPG ZIC2 RAD21 YY1 FOSL1 ZNF316 POLR2A GPALPP1 NUFIP1 SERP2 SMIM2-AS1 LACC1 CCDC122 GC13M044260 GC13M044319
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERP2 gene promoter:

Genomic Locations for SERP2 Gene

Genomic Locations for SERP2 Gene
24,050 bases
Plus strand

Genomic View for SERP2 Gene

Genes around SERP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP2 Gene

Proteins for SERP2 Gene

  • Protein details for SERP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Stress-associated endoplasmic reticulum protein 2
    Protein Accession:

    Protein attributes for SERP2 Gene

    65 amino acids
    Molecular mass:
    7431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERP2 Gene

Post-translational modifications for SERP2 Gene

No Post-translational modifications

Other Protein References for SERP2 Gene

No data available for DME Specific Peptides for SERP2 Gene

Domains & Families for SERP2 Gene

Gene Families for SERP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SERP2 Gene


Suggested Antigen Peptide Sequences for SERP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RAMP4 family.
  • Belongs to the RAMP4 family.
genes like me logo Genes that share domains with SERP2: view

Function for SERP2 Gene

Molecular function for SERP2 Gene

UniProtKB/Swiss-Prot Function:
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Phenotypes From GWAS Catalog for SERP2 Gene

Gene Ontology (GO) - Molecular Function for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERP2: view

Phenotypes for SERP2 Gene

genes like me logo Genes that share phenotypes with SERP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERP2 Gene

Localization for SERP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP2 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERP2 gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERP2 Gene

Pathways & Interactions for SERP2 Gene

SuperPathways for SERP2 Gene

No Data Available

Interacting Proteins for SERP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N6R1-SERP2_HUMAN ENSP00000368477 for SERP2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with SERP2: view

No data available for Pathways by source and SIGNOR curated interactions for SERP2 Gene

Drugs & Compounds for SERP2 Gene

No Compound Related Data Available

Transcripts for SERP2 Gene

mRNA/cDNA for SERP2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERP2 Gene

Stress-associated endoplasmic reticulum protein family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SERP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERP2 Gene

mRNA differential expression in normal tissues according to GTEx for SERP2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SERP2 Gene

This gene is overexpressed in Fetal Brain (39.7) and Frontal cortex (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERP2 Gene

Protein tissue co-expression partners for SERP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERP2 Gene:


SOURCE GeneReport for Unigene cluster for SERP2 Gene:


Evidence on tissue expression from TISSUES for SERP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SERP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERP2 Gene

Orthologs for SERP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERP2 33 34
  • 98.46 (n)
(Canis familiaris)
Mammalia SERP2 33 34
  • 96.92 (n)
(Mus musculus)
Mammalia Serp2 33 16 34
  • 95.38 (n)
(Bos Taurus)
Mammalia SERP2 33
  • 94.36 (n)
(Rattus norvegicus)
Mammalia Serp2 33
  • 92.59 (n)
(Monodelphis domestica)
Mammalia SERP2 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serp2 33
  • 87.18 (n)
(Danio rerio)
Actinopterygii serp2 33 34
  • 84.1 (n)
SERP2 (2 of 3) 34
  • 71 (a)
serp1 34
  • 64 (a)
wufc96h11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10319 33
fruit fly
(Drosophila melanogaster)
Insecta CG32276 34
  • 59 (a)
(Caenorhabditis elegans)
Secernentea F59F4.2 34
  • 60 (a)
T09A12.5 34
  • 54 (a)
Species where no ortholog for SERP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP2 Gene

Gene Tree for SERP2 (if available)
Gene Tree for SERP2 (if available)

Paralogs for SERP2 Gene

Paralogs for SERP2 Gene

(1) SIMAP similar genes for SERP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERP2: view

Variants for SERP2 Gene

Sequence variations from dbSNP and Humsavar for SERP2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000154772 -- 44,383,344(+) T/C intron_variant
rs1000286520 -- 44,390,303(+) C/G intron_variant
rs1000344744 -- 44,377,956(+) A/G intron_variant
rs1000484476 -- 44,383,704(+) T/C intron_variant
rs1000517203 -- 44,390,612(+) TTT/TTTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERP2 Gene

Variant ID Type Subtype PubMed ID
nsv1122813 CNV deletion 24896259

Variation tolerance for SERP2 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERP2 Gene

Disorders for SERP2 Gene

Additional Disease Information for SERP2

No disorders were found for SERP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERP2 Gene

Publications for SERP2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng JS … Lai CQ (PloS one 2013) 3 58
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 58

Products for SERP2 Gene

Sources for SERP2 Gene

Loading form....