Aliases for SERINC3 Gene

Aliases for SERINC3 Gene

  • Serine Incorporator 3 2 3 4 5
  • DIFF33 2 3 4
  • Tumor Differentially Expressed Protein 1 3 4
  • SBBI99 2 3
  • AIGP1 2 3
  • TMS-1 2 3
  • TDE1 3 4
  • TDE 2 3
  • Tumor Differentially Expressed 1 2
  • SERINC3 5

External Ids for SERINC3 Gene

Previous HGNC Symbols for SERINC3 Gene

  • TDE1

Previous GeneCards Identifiers for SERINC3 Gene

  • GC20M042559
  • GC20M043124
  • GC20M039866

Summaries for SERINC3 Gene

GeneCards Summary for SERINC3 Gene

SERINC3 (Serine Incorporator 3) is a Protein Coding gene. Diseases associated with SERINC3 include Dissociative Disorder and Rapp-Hodgkin Syndrome. Among its related pathways are Viral mRNA Translation and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

UniProtKB/Swiss-Prot Summary for SERINC3 Gene

  • Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Gene Wiki entry for SERINC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERINC3 Gene

Genomics for SERINC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERINC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044518 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 260.7 +0.7 711 4.8 TBP SP1 MXD4 CEBPA MNT IKZF1 SMAD5 ETS1 MBD2 ZNF217 SERINC3 lnc-ADA-6 lnc-PKIG-4 JPH2 PKIG TTPAL HSALNG0130323
GH20J044690 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -171.6 -171641 7 MXD4 CEBPA DEK ZNF217 BRCA1 HOMEZ CEBPB RAD51 MBD2 IRF3 KCNK15-AS1 ENSG00000132832 ADA CCN5 KCNK15 SERINC3 PKIG PIGT PABPC1L piR-60246-097
GH20J044552 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -31.0 -31016 4.6 FEZF1 ZNF639 SMAD4 TAL1 TAF9B RARA STAT3 BCL6 JUND FOSL1 PKIG SERINC3 ADA TTPAL AB372643-009
GH20J044489 Enhancer 1 Ensembl ENCODE dbSUPER 19 +31.0 31007 3.8 BCL11A ZIC2 EBF1 BATF IKZF1 TCF7 ATF2 JUNB TCF12 POLR2A HSALNG0130322 lnc-TTPAL-1 piR-44619 SERINC3 PKIG RPL37AP1 LINC01430 LINC01620 TTPAL
GH20J044493 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +26.1 26130 4.8 CEBPA CEBPB IRF4 EP300 RXRA EBF1 JUND FOSL1 CTCF BATF piR-52343 PKIG TTPAL SERINC3 RPL37AP1 LINC01430 LINC01620 OSER1 ADA STK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERINC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERINC3

Top Transcription factor binding sites by QIAGEN in the SERINC3 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • Elk-1
  • Ik-1
  • LCR-F1
  • LUN-1
  • MZF-1
  • Pax-4a

Genomic Locations for SERINC3 Gene

Latest Assembly
chr20:44,496,221-44,522,085
(GRCh38/hg38)
Size:
25,865 bases
Orientation:
Minus strand

Previous Assembly
chr20:43,124,862-43,150,711
(GRCh37/hg19 by Entrez Gene)
Size:
25,850 bases
Orientation:
Minus strand

chr20:43,124,862-43,150,750
(GRCh37/hg19 by Ensembl)
Size:
25,889 bases
Orientation:
Minus strand

Genomic View for SERINC3 Gene

Genes around SERINC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC3 Gene

Proteins for SERINC3 Gene

  • Protein details for SERINC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13530-SERC3_HUMAN
    Recommended name:
    Serine incorporator 3
    Protein Accession:
    Q13530
    Secondary Accessions:
    • B4DUE9
    • O43717
    • Q9BR33

    Protein attributes for SERINC3 Gene

    Size:
    473 amino acids
    Molecular mass:
    52580 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB48858.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAD34641.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for SERINC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC3 Gene

Post-translational modifications for SERINC3 Gene

Other Protein References for SERINC3 Gene

Antibodies for research

  • Abcam antibodies for SERINC3

No data available for DME Specific Peptides for SERINC3 Gene

Domains & Families for SERINC3 Gene

Gene Families for SERINC3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SERINC3 Gene

InterPro:
Blocks:
  • TMS membrane protein/tumour differentially expressed protein
ProtoNet:

Suggested Antigen Peptide Sequences for SERINC3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50869, highly similar to Serine incorporator 3 (B4DUE9_HUMAN)
  • Serine incorporator 3 (Q5H936_HUMAN)
  • Tumor differentially expressed protein 1 (SERC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13530

UniProtKB/Swiss-Prot:

SERC3_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC3: view

Function for SERINC3 Gene

Molecular function for SERINC3 Gene

UniProtKB/Swiss-Prot Function:
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Phenotypes From GWAS Catalog for SERINC3 Gene

Gene Ontology (GO) - Molecular Function for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with SERINC3: view
genes like me logo Genes that share phenotypes with SERINC3: view

Animal Models for SERINC3 Gene

MGI Knock Outs for SERINC3:

Animal Models for research

  • Taconic Biosciences Mouse Models for SERINC3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERINC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERINC3 Gene

Localization for SERINC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC3 Gene

Cell membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein.
Cytoplasm, perinuclear region. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305 PubMed:26416734}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
endoplasmic reticulum 2
endosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA 21873635
genes like me logo Genes that share ontologies with SERINC3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERINC3 Gene

Pathways & Interactions for SERINC3 Gene

genes like me logo Genes that share pathways with SERINC3: view

Interacting Proteins for SERINC3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 15)
STRING Interaction Network
Selected Interacting proteins: Q13530-SERC3_HUMAN ENSP00000340243 for SERINC3 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006564 L-serine biosynthetic process TAS --
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0009597 detection of virus IDA 26416733
genes like me logo Genes that share ontologies with SERINC3: view

No data available for SIGNOR curated interactions for SERINC3 Gene

Drugs & Compounds for SERINC3 Gene

No Compound Related Data Available

Transcripts for SERINC3 Gene

mRNA/cDNA for SERINC3 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERINC3

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for SERINC3 Gene

GeneLoc Exon Structure for
SERINC3

Expression for SERINC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERINC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC3 Gene

This gene is overexpressed in Placenta (20.7), Testis (14.7), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERINC3 Gene



Protein tissue co-expression partners for SERINC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERINC3

SOURCE GeneReport for Unigene cluster for SERINC3 Gene:

Hs.272168

mRNA Expression by UniProt/SwissProt for SERINC3 Gene:

Q13530-SERC3_HUMAN
Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Evidence on tissue expression from TISSUES for SERINC3 Gene

  • Nervous system(4.9)
  • Pancreas(4.3)
  • Lung(3.6)
  • Liver(3.5)
  • Kidney(3.1)
  • Heart(2.6)
  • Intestine(2.6)
  • Spleen(2.5)
  • Skin(2.5)
  • Blood(2.4)
  • Stomach(2.1)
  • Muscle(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SERINC3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC3 Gene

Orthologs for SERINC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERINC3 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SERINC3 30 31
  • 87.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SERINC3 30 31
  • 84.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Serinc3 30 17 31
  • 82.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Serinc3 30
  • 80.72 (n)
Oppossum
(Monodelphis domestica)
Mammalia SERINC3 31
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SERINC3 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SERINC3 30 31
  • 70.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SERINC3 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia serinc3 30
  • 66.81 (n)
Str.1226 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100535683 30
  • 61.92 (n)
SERINC3 31
  • 56 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta TMS1 31
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R11H6.2 31
  • 43 (a)
ManyToMany
Y57E12AL.1 31
  • 43 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 31 33 33
  • 31 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G16180 30
  • 48.05 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0792900 30
  • 48.05 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Species where no ortholog for SERINC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SERINC3 Gene

ENSEMBL:
Gene Tree for SERINC3 (if available)
TreeFam:
Gene Tree for SERINC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERINC3: view image

Paralogs for SERINC3 Gene

Paralogs for SERINC3 Gene

(4) SIMAP similar genes for SERINC3 Gene using alignment to 5 proteins:

  • SERC3_HUMAN
  • B4DUE9_HUMAN
  • L8E9G1_HUMAN
  • L8ECD5_HUMAN
  • Q5H936_HUMAN

Pseudogenes.org Pseudogenes for SERINC3 Gene

genes like me logo Genes that share paralogs with SERINC3: view

Variants for SERINC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERINC3 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
VAR_014315 - p.Thr437Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERINC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERINC3 Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958
nsv586065 CNV gain 21841781

Variation tolerance for SERINC3 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERINC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC3 Gene

Disorders for SERINC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SERINC3 Gene - From: COP

Disorder Aliases PubMed IDs
dissociative disorder
  • dissociative disease
rapp-hodgkin syndrome
  • rhs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERINC3

genes like me logo Genes that share disorders with SERINC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERINC3 Gene

Publications for SERINC3 Gene

  1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PMID: 10559794) Bossolasco M … Mes-Masson AM (Molecular carcinogenesis 1999) 2 3 4
  2. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. (PMID: 26416734) Rosa A … Pizzato M (Nature 2015) 3 4
  3. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. (PMID: 26416733) Usami Y … Göttlinger HG (Nature 2015) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for SERINC3 Gene

Sources for SERINC3 Gene