Aliases for SERINC2 Gene

Aliases for SERINC2 Gene

  • Serine Incorporator 2 2 3 4 5
  • TDE2L 3 4
  • Tumor Differentially Expressed Protein 2-Like 4
  • Tumor Differentially Expressed Protein 2 3
  • Tumor Differentially Expressed 2-Like 2
  • PRO0899 3
  • FKSG84 3
  • TDE2 3

External Ids for SERINC2 Gene

Previous HGNC Symbols for SERINC2 Gene

  • TDE2L

Previous GeneCards Identifiers for SERINC2 Gene

  • GC01P031556
  • GC01P031659
  • GC01P031883
  • GC01P030003

Summaries for SERINC2 Gene

GeneCards Summary for SERINC2 Gene

SERINC2 (Serine Incorporator 2) is a Protein Coding gene. Among its related pathways are Amino acid synthesis and interconversion (transamination) and Metabolism. Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

Additional gene information for SERINC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERINC2 Gene

Genomics for SERINC2 Gene

GeneHancer (GH) Regulatory Elements for SERINC2 Gene

Promoters and enhancers for SERINC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J031409 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 536.9 +4.1 4058 8.4 EP300 FOXK2 POLR2G NCOR1 PHF8 TEAD4 ZFX ZIC2 POLR2A KDM6A SERINC2 TINAGL1 ENSG00000229167 ENSG00000229044 SNRNP40 lnc-SERINC2-2
GH01J031408 Enhancer 0.2 Ensembl 534.9 -0.6 -564 0.4 SERINC2 RF00017-142
GH01J031370 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 38.8 -36.1 -36107 8.5 EP300 USF1 JUND FOS TEAD4 TRIM28 SAP30 RFX1 CTBP1 SKI FABP3 SERINC2 FAM229A TSSK3 SNRNP40 TMEM39B DCDC2B TMEM234 lnc-FABP3-3 ENSG00000229044
GH01J031295 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 26 -112.7 -112664 3 ZBTB40 CTCF SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 JUND ZFX SNRNP40 NONHSAG000899.2 ZCCHC17 lnc-SNRNP40-3 SERINC2 KHDRBS1 EIF3I TXLNA ENSG00000228634 ENSG00000229447
GH01J031420 Enhancer 1.3 Ensembl ENCODE dbSUPER 37.6 +14.4 14434 6.8 CTCF FOS ZNF639 ZNF10 TARDBP REST RUNX1 RAD21 EP300 CTBP1 SERINC2 FABP3 ENSG00000229167 TINAGL1 SNRNP40 lnc-SERINC2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERINC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERINC2

Top Transcription factor binding sites by QIAGEN in the SERINC2 gene promoter:
  • AP-4
  • AREB6
  • c-Myc
  • E47
  • Max1
  • Pax-2
  • POU2F1
  • POU2F1a
  • RORalpha1
  • Tal-1

Genomic Locations for SERINC2 Gene

Genomic Locations for SERINC2 Gene
chr1:31,409,565-31,434,680
(GRCh38/hg38)
Size:
25,116 bases
Orientation:
Plus strand
chr1:31,882,412-31,907,527
(GRCh37/hg19)
Size:
25,116 bases
Orientation:
Plus strand

Genomic View for SERINC2 Gene

Genes around SERINC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC2 Gene

Proteins for SERINC2 Gene

  • Protein details for SERINC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SA4-SERC2_HUMAN
    Recommended name:
    Serine incorporator 2
    Protein Accession:
    Q96SA4
    Secondary Accessions:
    • A0AVB4
    • B4DJK5
    • B7Z567
    • B7ZAP2
    • E7EUZ9
    • Q86Y23

    Protein attributes for SERINC2 Gene

    Size:
    455 amino acids
    Molecular mass:
    50742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC2 Gene

Post-translational modifications for SERINC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC2 Gene

No data available for DME Specific Peptides for SERINC2 Gene

Domains & Families for SERINC2 Gene

Gene Families for SERINC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SERINC2 Gene

Blocks:
  • TMS membrane protein/tumour differentially expressed protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERINC2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60277, highly similar to Serine incorporator 2 (B4DJK5_HUMAN)
  • Serine incorporator 2, isoform CRA_b (D3DPN6_HUMAN)
  • SERINC2 protein (Q96AI1_HUMAN)
  • SERINC2 protein (Q96IM8_HUMAN)
  • Tumor differentially expressed protein 2-like (SERC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96SA4

UniProtKB/Swiss-Prot:

SERC2_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC2: view

Function for SERINC2 Gene

Phenotypes From GWAS Catalog for SERINC2 Gene

genes like me logo Genes that share phenotypes with SERINC2: view

Animal Model Products

CRISPR Products

miRNA for SERINC2 Gene

miRTarBase miRNAs that target SERINC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERINC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC2 Gene

Localization for SERINC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC2 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SERINC2: view

Pathways & Interactions for SERINC2 Gene

genes like me logo Genes that share pathways with SERINC2: view

Gene Ontology (GO) - Biological Process for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:1904219 positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA --
GO:1904222 positive regulation of serine C-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with SERINC2: view

No data available for SIGNOR curated interactions for SERINC2 Gene

Drugs & Compounds for SERINC2 Gene

No Compound Related Data Available

Transcripts for SERINC2 Gene

mRNA/cDNA for SERINC2 Gene

5 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERINC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11: - -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SERINC2 Gene

GeneLoc Exon Structure for
SERINC2

Expression for SERINC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERINC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERINC2 Gene

This gene is overexpressed in Liver (x8.0), Minor Salivary Gland (x4.9), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for SERINC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERINC2 Gene



Protein tissue co-expression partners for SERINC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERINC2

SOURCE GeneReport for Unigene cluster for SERINC2 Gene:

Hs.270655

Evidence on tissue expression from TISSUES for SERINC2 Gene

  • Kidney(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SERINC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC2 Gene

Orthologs for SERINC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC2 31 30
  • 98.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SERINC2 31 31 30
  • 88.41 (n)
OneToMany
dog
(Canis familiaris)
Mammalia SERINC2 31 30
  • 87.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serinc2 30
  • 84.96 (n)
mouse
(Mus musculus)
Mammalia Serinc2 17 31 30
  • 84.89 (n)
oppossum
(Monodelphis domestica)
Mammalia SERINC2 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC2 31 30
  • 72.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC2 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc2 30
  • 63.53 (n)
zebrafish
(Danio rerio)
Actinopterygii serinc2l 31 30
  • 66.15 (n)
OneToMany
serinc2 31
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TMS1 31
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 31
  • 40 (a)
ManyToMany
Y57E12AL.1 31
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 31
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Species where no ortholog for SERINC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC2 Gene

ENSEMBL:
Gene Tree for SERINC2 (if available)
TreeFam:
Gene Tree for SERINC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERINC2: view image

Paralogs for SERINC2 Gene

Paralogs for SERINC2 Gene

(4) SIMAP similar genes for SERINC2 Gene using alignment to 4 proteins:

  • SERC2_HUMAN
  • D3DPN6_HUMAN
  • Q96AI1_HUMAN
  • Q96IM8_HUMAN
genes like me logo Genes that share paralogs with SERINC2: view

Variants for SERINC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERINC2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
785935 Benign: not provided 31,424,740(+) G/A MISSENSE_VARIANT
787526 Benign: not provided 31,429,409(+) ACC/A FRAMESHIFT_VARIANT
788760 Benign: not provided 31,424,709(+) C/T SYNONYMOUS_VARIANT
rs34728687 - p.Gly303Ser

Additional dbSNP identifiers (rs#s) for SERINC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERINC2 Gene

Variant ID Type Subtype PubMed ID
esv1004118 CNV insertion 20482838
esv1133300 CNV insertion 17803354
esv1676191 CNV insertion 17803354
esv21814 CNV gain 19812545
esv2746341 CNV deletion 23290073
esv2746352 CNV deletion 23290073
esv2758930 CNV loss 17122850
esv3577802 CNV loss 25503493
nsv509135 CNV insertion 20534489
nsv7712 CNV insertion 18451855
nsv950383 CNV deletion 24416366

Variation tolerance for SERINC2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERINC2 Gene

Human Gene Mutation Database (HGMD)
SERINC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC2 Gene

Disorders for SERINC2 Gene

Additional Disease Information for SERINC2

No disorders were found for SERINC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC2 Gene

Publications for SERINC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Identification of TDE2 gene and its expression in non-small cell lung cancer. (PMID: 12949800) Player A … Jen J (International journal of cancer 2003) 2 3 54
  5. Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5. (PMID: 29268082) Schulte B … Diaz-Griffero F (Virology 2018) 3 54

Products for SERINC2 Gene

Sources for SERINC2 Gene