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Aliases for SERINC2 Gene

Aliases for SERINC2 Gene

  • Serine Incorporator 2 2 3 3 5
  • TDE2L 3 4
  • Tumor Differentially Expressed Protein 2-Like 4
  • Tumor Differentially Expressed Protein 2 3
  • Tumor Differentially Expressed 2-Like 2
  • PRO0899 3
  • FKSG84 3
  • TDE2 3

External Ids for SERINC2 Gene

Previous HGNC Symbols for SERINC2 Gene

  • TDE2L

Previous GeneCards Identifiers for SERINC2 Gene

  • GC01P031556
  • GC01P031659
  • GC01P031883
  • GC01P030003

Summaries for SERINC2 Gene

GeneCards Summary for SERINC2 Gene

SERINC2 (Serine Incorporator 2) is a Protein Coding gene. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

Additional gene information for SERINC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC2 Gene

Genomics for SERINC2 Gene

GeneHancer (GH) Regulatory Elements for SERINC2 Gene

Promoters and enhancers for SERINC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J031412 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 686.6 +5.6 5645 5.3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF213 SP5 ZHX2 MXD4 SERINC2 LOC105378626 TINAGL1 ENSG00000229044 LOC105378625
GH01J031409 Enhancer 0.9 Ensembl ENCODE 685.3 +1.0 993 2.1 MEIS2 PKNOX1 TAL1 E4F1 TCF12 POLR2A NCOR1 CBFA2T2 STAT1 ZNF3 SERINC2 LOC105378625
GH01J031370 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.8 -35.6 -35564 7.4 ARID4B SIN3A ZNF48 ETS1 FOS ATF7 RXRA SP5 RFX3 GLIS1 FABP3 SERINC2 FAM229A TSSK3 SNRNP40 TMEM39B DCDC2B TMEM234 GC01M031352 GC01M031377
GH01J031420 Enhancer 1.4 Ensembl ENCODE dbSUPER 37.6 +13.1 13143 4 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 GLIS2 ARID2 ZNF143 SERINC2 FABP3 TINAGL1 LOC105378626 SNRNP40 LOC105378625
GH01J031295 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 26 -112.6 -112648 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SNRNP40 ZCCHC17 TXLNA SERINC2 KHDRBS1 KPNA6 TMEM39B EIF3I ENSG00000229447 DCDC2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERINC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERINC2 gene promoter:
  • Max1
  • c-Myc
  • AREB6
  • RORalpha1
  • E47
  • Tal-1
  • AP-4
  • POU2F1
  • POU2F1a
  • Pax-2

Genomic Locations for SERINC2 Gene

Genomic Locations for SERINC2 Gene
25,116 bases
Plus strand
25,116 bases
Plus strand

Genomic View for SERINC2 Gene

Genes around SERINC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC2 Gene

Proteins for SERINC2 Gene

  • Protein details for SERINC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine incorporator 2
    Protein Accession:
    Secondary Accessions:
    • A0AVB4
    • B4DJK5
    • B7Z567
    • B7ZAP2
    • E7EUZ9
    • Q86Y23

    Protein attributes for SERINC2 Gene

    455 amino acids
    Molecular mass:
    50742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC2 Gene


neXtProt entry for SERINC2 Gene

Post-translational modifications for SERINC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC2 Gene

No data available for DME Specific Peptides for SERINC2 Gene

Domains & Families for SERINC2 Gene

Gene Families for SERINC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SERINC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TDE1 family.
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC2: view

Function for SERINC2 Gene

Phenotypes From GWAS Catalog for SERINC2 Gene

Gene Ontology (GO) - Molecular Function for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC2: view
genes like me logo Genes that share phenotypes with SERINC2: view

Animal Model Products

miRNA for SERINC2 Gene

miRTarBase miRNAs that target SERINC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC2 Gene

Localization for SERINC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC2 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SERINC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERINC2 Gene

Pathways & Interactions for SERINC2 Gene

genes like me logo Genes that share pathways with SERINC2: view

Gene Ontology (GO) - Biological Process for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0015825 L-serine transport IEA --
GO:1904219 positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA --
GO:1904222 positive regulation of serine C-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with SERINC2: view

No data available for SIGNOR curated interactions for SERINC2 Gene

Drugs & Compounds for SERINC2 Gene

No Compound Related Data Available

Transcripts for SERINC2 Gene

Unigene Clusters for SERINC2 Gene

Serine incorporator 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - -
SP7: - - - - - -
SP8: -
SP10: - - - - - - - -
SP11: - -

ExUns: 16 ^ 17

Relevant External Links for SERINC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERINC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERINC2 Gene

This gene is overexpressed in Liver (x8.0), Minor Salivary Gland (x4.9), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for SERINC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERINC2 Gene

Protein tissue co-expression partners for SERINC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERINC2 Gene:


SOURCE GeneReport for Unigene cluster for SERINC2 Gene:


Evidence on tissue expression from TISSUES for SERINC2 Gene

  • Kidney(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SERINC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC2 Gene

Orthologs for SERINC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERINC2 34 33
  • 98.59 (n)
(Bos Taurus)
Mammalia SERINC2 34 34 33
  • 88.41 (n)
(Canis familiaris)
Mammalia SERINC2 34 33
  • 87.24 (n)
(Rattus norvegicus)
Mammalia Serinc2 33
  • 84.96 (n)
(Mus musculus)
Mammalia Serinc2 16 34 33
  • 84.89 (n)
(Monodelphis domestica)
Mammalia SERINC2 34
  • 79 (a)
(Gallus gallus)
Aves SERINC2 34 33
  • 72.87 (n)
(Anolis carolinensis)
Reptilia SERINC2 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc2 33
  • 63.53 (n)
(Danio rerio)
Actinopterygii serinc2l 34 33
  • 66.15 (n)
serinc2 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea R11H6.2 34
  • 40 (a)
Y57E12AL.1 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
-- 34
  • 40 (a)
Species where no ortholog for SERINC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC2 Gene

Gene Tree for SERINC2 (if available)
Gene Tree for SERINC2 (if available)
Evolutionary constrained regions (ECRs) for SERINC2: view image

Paralogs for SERINC2 Gene

Paralogs for SERINC2 Gene

(4) SIMAP similar genes for SERINC2 Gene using alignment to 4 proteins:

  • Q96AI1_HUMAN
  • Q96IM8_HUMAN
genes like me logo Genes that share paralogs with SERINC2: view

Variants for SERINC2 Gene

Sequence variations from dbSNP and Humsavar for SERINC2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000205693 -- 31,420,099(+) C/T intron_variant
rs1000791489 -- 31,410,185(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000867736 -- 31,427,662(+) G/A intron_variant
rs1000920091 -- 31,427,331(+) A/G intron_variant
rs1001032151 -- 31,432,735(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC2 Gene

Variant ID Type Subtype PubMed ID
esv1004118 CNV insertion 20482838
esv1133300 CNV insertion 17803354
esv1676191 CNV insertion 17803354
esv21814 CNV gain 19812545
esv2746341 CNV deletion 23290073
esv2746352 CNV deletion 23290073
esv2758930 CNV loss 17122850
esv3577802 CNV loss 25503493
nsv509135 CNV insertion 20534489
nsv7712 CNV insertion 18451855
nsv950383 CNV deletion 24416366

Variation tolerance for SERINC2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERINC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC2 Gene

Disorders for SERINC2 Gene

Additional Disease Information for SERINC2

No disorders were found for SERINC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC2 Gene

Publications for SERINC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of TDE2 gene and its expression in non-small cell lung cancer. (PMID: 12949800) Player A … Jen J (International journal of cancer 2003) 2 3 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5. (PMID: 29268082) Schulte B … Diaz-Griffero F (Virology 2018) 3 58

Products for SERINC2 Gene

Sources for SERINC2 Gene

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