Aliases for SERHL Gene

Aliases for SERHL Gene

  • Serine Hydrolase Like (Pseudogene) 2 3 5
  • Serine Hydrolase-Like 2 3
  • Kraken-Like 2 3
  • Serine Hydrolase-Like Protein 4
  • DJ222E13.1 3
  • EC 3.1.-.- 4
  • BK126B4.1 3
  • BK126B4.2 3
  • HS126B42 3
  • SERHL2 4
  • SHL 4

External Ids for SERHL Gene

Previous GeneCards Identifiers for SERHL Gene

  • GC22P039499
  • GC22P041127
  • GC22P041221
  • GC22P042896
  • GC22P025862

Summaries for SERHL Gene

GeneCards Summary for SERHL Gene

SERHL (Serine Hydrolase Like (Pseudogene)) is a Pseudogene. Diseases associated with SERHL include Cervical Squamous Cell Carcinoma and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot Summary for SERHL Gene

Additional gene information for SERHL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERHL Gene

Genomics for SERHL Gene

GeneHancer (GH) Regulatory Elements for SERHL Gene

Promoters and enhancers for SERHL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J042498 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.8 -834 3.3 ZNF217 NRF1 SP1 TARDBP RFX1 CUX1 CTBP1 POLR2A DEAF1 NCOR1 SERHL lnc-SERHL2-1 RRP7A RRP7BP NFAM1 CYB5R3 piR-43107-209
GH22J042340 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 4.9 -159.9 -159873 1.4 EP300 ZIC2 ZNF423 ZBTB26 POLR2A BCL11A WT1 NFIC SMC3 YY1 LINC01315 ENSG00000230107 SERHL DESI1 SEPTIN3 TCF20 HSALNG0135700
GH22J042414 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.4 -85.4 -85367 2.4 ZIC2 KDM6A SPI1 FOSL2 HHEX RARA NR2F6 ATF2 HMG20A ZBTB33 NDUFA6 NAGA SERHL SNU13 piR-32214-454 NFAM1
GH22J042506 Enhancer 0.2 dbSUPER 5.4 +6.0 5997 1 LOC101927372 RRP7BP CYB5R3 SERHL lnc-SERHL2-1 piR-30460-001
GH22J042511 Enhancer 0.8 ENCODE dbSUPER 0.4 +11.4 11422 1.9 CTCF ZIC2 REST NFIC SMC3 POLR2G RBM22 ZFHX2 SUPT5H ZNF654 piR-30460-001 piR-50190 RRP7BP RRP7A CYB5R3 LOC101927372 lnc-SERHL2-1 SERHL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERHL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERHL gene promoter:
  • AML1a
  • COMP1
  • En-1
  • FOXF2
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • RelA

Genomic Locations for SERHL Gene

Genomic Locations for SERHL Gene
chr22:42,500,568-42,512,560
(GRCh38/hg38)
Size:
11,993 bases
Orientation:
Plus strand
chr22:42,896,585-42,908,566
(GRCh37/hg19)
Size:
11,982 bases
Orientation:
Plus strand

Genomic View for SERHL Gene

Genes around SERHL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERHL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERHL Gene

Proteins for SERHL Gene

  • Protein details for SERHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQF3-SERHL_HUMAN
    Recommended name:
    Serine hydrolase-like protein
    Protein Accession:
    Q9NQF3
    Secondary Accessions:
    • Q5JZ95
    • Q9UH21

    Protein attributes for SERHL Gene

    Size:
    203 amino acids
    Molecular mass:
    22471 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene may have been partially duplicated (see SERHL2).

neXtProt entry for SERHL Gene

Post-translational modifications for SERHL Gene

No Post-translational modifications

No data available for DME Specific Peptides for SERHL Gene

Domains & Families for SERHL Gene

Protein Domains for SERHL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERHL Gene

GenScript: Design optimal peptide antigens:
  • Serine hydrolase-like protein (SERHL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQF3

UniProtKB/Swiss-Prot:

SERHL_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with SERHL: view

No data available for Gene Families for SERHL Gene

Function for SERHL Gene

Molecular function for SERHL Gene

UniProtKB/Swiss-Prot Function:
Putative serine hydrolase.

Enzyme Numbers (IUBMB) for SERHL Gene

Phenotypes From GWAS Catalog for SERHL Gene

Gene Ontology (GO) - Molecular Function for SERHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SERHL: view
genes like me logo Genes that share phenotypes with SERHL: view

Animal Model Products

CRISPR Products

miRNA for SERHL Gene

miRTarBase miRNAs that target SERHL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERHL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERHL Gene

Localization for SERHL Gene

Gene Ontology (GO) - Cellular Components for SERHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SERHL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SERHL Gene

Pathways & Interactions for SERHL Gene

PathCards logo

SuperPathways for SERHL Gene

No Data Available

Interacting Proteins for SERHL Gene

Selected Interacting proteins: Q9NQF3-SERHL_HUMAN for SERHL Gene via IID

Symbol External ID(s) Details
TFAP2A
;

Gene Ontology (GO) - Biological Process for SERHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SERHL: view

No data available for Pathways by source and SIGNOR curated interactions for SERHL Gene

Drugs & Compounds for SERHL Gene

No Compound Related Data Available

Transcripts for SERHL Gene

mRNA/cDNA for SERHL Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERHL

Alternative Splicing Database (ASD) splice patterns (SP) for SERHL Gene

No ASD Table

Relevant External Links for SERHL Gene

GeneLoc Exon Structure for
SERHL

Expression for SERHL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERHL

SOURCE GeneReport for Unigene cluster for SERHL Gene:

Hs.360940
genes like me logo Genes that share expression patterns with SERHL: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERHL Gene

Orthologs for SERHL Gene

This gene was present in the common ancestor of animals.

Orthologs for SERHL Gene

Organism Taxonomy Gene Similarity Type Details
fruit fly
(Drosophila melanogaster)
Insecta kraken 32
  • 33 (a)
CG7632 32
  • 32 (a)
CG11309 32
  • 31 (a)
CG15879 32
  • 30 (a)
CG15820 32
  • 30 (a)
Species where no ortholog for SERHL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERHL Gene

ENSEMBL:
Gene Tree for SERHL (if available)
TreeFam:
Gene Tree for SERHL (if available)

Paralogs for SERHL Gene

(1) SIMAP similar genes for SERHL Gene using alignment to 1 proteins:

  • SERHL_HUMAN
genes like me logo Genes that share paralogs with SERHL: view

No data available for Paralogs for SERHL Gene

Variants for SERHL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERHL Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs3213549 - p.Glu3Lys

Structural Variations from Database of Genomic Variants (DGV) for SERHL Gene

Variant ID Type Subtype PubMed ID
dgv101e203 CNV gain+loss 21179565
dgv103e180 CNV gain 20482838
dgv1321e212 CNV gain 25503493
dgv173n111 CNV duplication 26073780
dgv174n111 CNV duplication 26073780
dgv175n111 CNV duplication 26073780
dgv4576n100 CNV gain 25217958
dgv4577n100 CNV gain 25217958
dgv4578n100 CNV gain 25217958
dgv4579n100 CNV gain+loss 25217958
dgv4580n100 CNV gain+loss 25217958
dgv4581n100 CNV gain 25217958
dgv4582n100 CNV gain+loss 25217958
dgv4583n100 CNV gain+loss 25217958
dgv4584n100 CNV gain 25217958
dgv4585n100 CNV gain 25217958
dgv734e201 CNV deletion 23290073
dgv773n67 CNV gain 20364138
dgv8117n54 CNV gain 21841781
dgv842e214 CNV gain 21293372
esv2659886 CNV deletion 23128226
esv2724283 CNV deletion 23290073
esv2758839 CNV gain+loss 17122850
esv28197 CNV gain 19812545
esv32632 CNV gain 17666407
esv3568421 CNV loss 25503493
esv3575487 CNV gain 25503493
esv3575488 CNV gain 25503493
esv3647819 CNV gain 21293372
esv3647831 CNV loss 21293372
nsv1055597 CNV gain 25217958
nsv1056323 CNV loss 25217958
nsv1062078 CNV loss 25217958
nsv1064178 CNV gain 25217958
nsv1160770 CNV duplication 26073780
nsv1160775 CNV deletion 26073780
nsv428391 CNV gain 18775914
nsv442798 CNV gain+loss 18776908
nsv589065 CNV gain 21841781
nsv589071 CNV loss 21841781
nsv829246 CNV loss 20364138
nsv9912 CNV gain+loss 18304495

Additional Variant Information for SERHL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERHL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for SERHL Gene

Disorders for SERHL Gene

MalaCards: The human disease database

(2) MalaCards diseases for SERHL Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search SERHL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SERHL

genes like me logo Genes that share disorders with SERHL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERHL Gene

Publications for SERHL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4 54
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 54
  4. Genome-wide association study identified copy number variants important for appendicular lean mass. (PMID: 24626161) Ran S … Deng HW (PloS one 2014) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for SERHL Gene

Sources for SERHL Gene