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Aliases for SERF2 Gene

Aliases for SERF2 Gene

  • Small EDRK-Rich Factor 2 2 3 5
  • Gastric Cancer-Related Protein VRG107 3 4
  • Protein 4F5-Related 3 4
  • H4F5REL 3 4
  • 4F5REL 3 4
  • FAM2C 3 4
  • HsT17089 3

External Ids for SERF2 Gene

Previous GeneCards Identifiers for SERF2 Gene

  • GC15P039436
  • GC15P036965
  • GC15P041648
  • GC15P041785
  • GC15P041856
  • GC15P044069
  • GC15P020907

Summaries for SERF2 Gene

GeneCards Summary for SERF2 Gene

SERF2 (Small EDRK-Rich Factor 2) is a Protein Coding gene.

Gene Wiki entry for SERF2 Gene

Additional gene information for SERF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERF2 Gene

Genomics for SERF2 Gene

GeneHancer (GH) Regulatory Elements for SERF2 Gene

Promoters and enhancers for SERF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.4 +19.4 19408 10.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D GC15M043788 GC15P043795 HYPK PIR54305 SERINC4 SERF2 SPG11 CTDSPL2 ENSG00000259563 RPS3AP47
GH15I043774 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.6 -613 3.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF207 ELL3 SERF2 WDR76 ADAL SPG11 STRC ENSG00000259563 CTDSPL2 MFAP1 ENSG00000262560
GH15I043749 Enhancer 0.6 ENCODE 11.8 -26.9 -26882 1.7 ZNF121 PKNOX1 ZNF384 ATF7 PRDM10 ELF1 PRDM1 ZNF18 STRC SERF2 MIR1282 HYPK PDIA3 CATSPER2P1
GH15I043434 Enhancer 0.5 ENCODE 10.2 -342.4 -342439 0.4 ZNF639 ZNF766 ZBTB11 GABPA ZSCAN29 TUBGCP4 MIR1282 HYPK SERF2 PIR42778 PIR48108 TP53BP1
GH15I043769 Enhancer 0.6 ENCODE 0.4 -7.3 -7289 0.2 CTCF FOXA2 TEAD1 FOXA3 TEAD4 TRIM22 ZNF384 RAD21 RFX5 MAFF MIR1282 HYPK SERF2 CATSPER2P1 PDIA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERF2 gene promoter:

Genomic Locations for SERF2 Gene

Genomic Locations for SERF2 Gene
chr15:43,777,087-43,802,589
(GRCh38/hg38)
Size:
25,503 bases
Orientation:
Plus strand
chr15:44,069,285-44,094,787
(GRCh37/hg19)

Genomic View for SERF2 Gene

Genes around SERF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERF2 Gene

Proteins for SERF2 Gene

  • Protein details for SERF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84101-SERF2_HUMAN
    Recommended name:
    Small EDRK-rich factor 2
    Protein Accession:
    P84101
    Secondary Accessions:
    • A6NL45
    • B5MCG1
    • B9A026
    • O75918
    • O88891
    • Q9BZH7

    Protein attributes for SERF2 Gene

    Size:
    59 amino acids
    Molecular mass:
    6900 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK07636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for SERF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERF2 Gene

Post-translational modifications for SERF2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SERF2 Gene

Domains & Families for SERF2 Gene

Gene Families for SERF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84101

UniProtKB/Swiss-Prot:

SERF2_HUMAN :
  • Belongs to the SERF family.
Family:
  • Belongs to the SERF family.
genes like me logo Genes that share domains with SERF2: view

Function for SERF2 Gene

Gene Ontology (GO) - Molecular Function for SERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SERF2: view

Phenotypes for SERF2 Gene

GenomeRNAi human phenotypes for SERF2:
genes like me logo Genes that share phenotypes with SERF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERF2 Gene

Localization for SERF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERF2 gene
Compartment Confidence
nucleus 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with SERF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SERF2 Gene

Pathways & Interactions for SERF2 Gene

SuperPathways for SERF2 Gene

No Data Available

Interacting Proteins for SERF2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000387187%0d%0a9606.ENSP00000304350%0d%0a9606.ENSP00000359454%0d%0a9606.ENSP00000317123%0d%0a9606.ENSP00000358159%0d%0a9606.ENSP00000264233%0d%0a
Selected Interacting proteins: ENSP00000387187 P84101-SERF2_HUMAN for SERF2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SERF2: view

No data available for Pathways by source and SIGNOR curated interactions for SERF2 Gene

Drugs & Compounds for SERF2 Gene

No Compound Related Data Available

Transcripts for SERF2 Gene

Unigene Clusters for SERF2 Gene

Small EDRK-rich factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7:
SP8: - - -
SP9: -
SP10: - - - -

Relevant External Links for SERF2 Gene

GeneLoc Exon Structure for
SERF2
ECgene alternative splicing isoforms for
SERF2

Expression for SERF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.4) and Ovary (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERF2 Gene



Protein tissue co-expression partners for SERF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERF2 Gene:

SERF2

SOURCE GeneReport for Unigene cluster for SERF2 Gene:

Hs.424126

Evidence on tissue expression from TISSUES for SERF2 Gene

  • Lung(4.9)
  • Pancreas(4.6)
  • Nervous system(4.6)
  • Heart(4.3)
  • Liver(4.3)
  • Skin(3.9)
  • Blood(3.4)
  • Intestine(3.1)
  • Muscle(2.8)
  • Eye(2.7)
  • Kidney(2.5)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with SERF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERF2 Gene

Orthologs for SERF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERF2 33
  • 100 (n)
ptr-mir-1282-1 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERF2 33
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SERF2 33 34
  • 99.44 (n)
mouse
(Mus musculus)
Mammalia Serf2 33 16
  • 97.74 (n)
rat
(Rattus norvegicus)
Mammalia Serf2 33
  • 97.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5567 33
zebrafish
(Danio rerio)
Actinopterygii Dr.14289 33
Species where no ortholog for SERF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERF2 Gene

ENSEMBL:
Gene Tree for SERF2 (if available)
TreeFam:
Gene Tree for SERF2 (if available)

Paralogs for SERF2 Gene

(2) SIMAP similar genes for SERF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SERF2: view

No data available for Paralogs for SERF2 Gene

Variants for SERF2 Gene

Sequence variations from dbSNP and Humsavar for SERF2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000304083 -- 43,796,488(+) T/G downstream_transcript_variant
rs1000521898 -- 43,776,887(+) C/G upstream_transcript_variant
rs1000849516 -- 43,778,702(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000977658 -- 43,777,190(+) AGAG/AG 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000991580 -- 43,778,880(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERF2 Gene

Variant ID Type Subtype PubMed ID
esv2760028 CNV gain+loss 17122850
nsv1036318 CNV gain 25217958

Variation tolerance for SERF2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERF2 Gene

Disorders for SERF2 Gene

Additional Disease Information for SERF2

No disorders were found for SERF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERF2 Gene

Publications for SERF2 Gene

  1. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. (PMID: 9731538) Scharf JM … Kunkel LM (Nature genetics 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  5. Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. (PMID: 20723760) van Ham TJ … Nollen EA (Cell 2010) 3 58

Products for SERF2 Gene

Sources for SERF2 Gene

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