Aliases for SERBP1 Gene

Aliases for SERBP1 Gene

  • SERPINE1 MRNA Binding Protein 1 2 3 5
  • PAI-RBP1 2 3 4
  • PAIRBP1 2 3 4
  • Plasminogen Activator Inhibitor 1 RNA-Binding Protein 3 4
  • PAI1 RNA-Binding Protein 1 3 4
  • CGI-55 2 3
  • CHD3IP 2 3
  • HABP4L 2 3
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • SERPINE1 MRNA-Binding Protein 1 4
  • PAI-1 MRNA Binding Protein 3
  • DKFZP564M2423 2
  • SERBP1 5

External Ids for SERBP1 Gene

Previous GeneCards Identifiers for SERBP1 Gene

  • GC01M067590
  • GC01M067873
  • GC01M065983

Summaries for SERBP1 Gene

GeneCards Summary for SERBP1 Gene

SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. Diseases associated with SERBP1 include Ovarian Cancer. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer. Gene Ontology (GO) annotations related to this gene include mRNA 3'-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot Summary for SERBP1 Gene

  • May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).

Gene Wiki entry for SERBP1 Gene

Additional gene information for SERBP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERBP1 Gene

Genomics for SERBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERBP1

Top Transcription factor binding sites by QIAGEN in the SERBP1 gene promoter:
  • AhR
  • Arnt
  • Bach2
  • C/EBPalpha
  • E47
  • FOXF2
  • Ik-1
  • Pax-2
  • Pax-4a
  • Tal-1beta

Genomic Locations for SERBP1 Gene

Genomic Locations for SERBP1 Gene
chr1:67,407,810-67,430,415
(GRCh38/hg38)
Size:
22,606 bases
Orientation:
Minus strand
chr1:67,873,493-67,896,123
(GRCh37/hg19)
Size:
22,631 bases
Orientation:
Minus strand

Genomic View for SERBP1 Gene

Genes around SERBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERBP1 Gene

Proteins for SERBP1 Gene

  • Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC51-PAIRB_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Protein Accession:
    Q8NC51
    Secondary Accessions:
    • Q5VU19
    • Q5VU20
    • Q5VU22
    • Q8WUH0
    • Q96SE2
    • Q9BTY3
    • Q9BUM4
    • Q9Y367
    • Q9Y4S3

    Protein attributes for SERBP1 Gene

    Size:
    408 amino acids
    Molecular mass:
    44965 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3 (PubMed:12505151, PubMed:18632687). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).
    Miscellaneous:
    • [Isoform 2]: May be due to a competing acceptor splice site.
    • [Isoform 3]: May be due to a competing acceptor splice site.

    Three dimensional structures from OCA and Proteopedia for SERBP1 Gene

    Alternative splice isoforms for SERBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERBP1 Gene

Post-translational modifications for SERBP1 Gene

  • Ubiquitination at Lys52, Lys68, Lys122, Lys236, Lys294, and Lys320
  • Modification sites at PhosphoSitePlus

Other Protein References for SERBP1 Gene

No data available for DME Specific Peptides for SERBP1 Gene

Domains & Families for SERBP1 Gene

Gene Families for SERBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERBP1 Gene

Suggested Antigen Peptide Sequences for SERBP1 Gene

GenScript: Design optimal peptide antigens:
  • SERPINE1 mRNA binding protein 1, isoform CRA_c (D3DQ69_HUMAN)
  • SERPINE1 mRNA binding protein 1, isoform CRA_d (D3DQ70_HUMAN)
  • SERPINE1 mRNA-binding protein 1 (PAIRB_HUMAN)
  • cDNA, FLJ92551, Homo sapiens PAI-1 mRNA-binding protein (PAI-RBP1), mRNA (Q5VU21_HUMAN)
genes like me logo Genes that share domains with SERBP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SERBP1 Gene

Function for SERBP1 Gene

Molecular function for SERBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).

Phenotypes From GWAS Catalog for SERBP1 Gene

Gene Ontology (GO) - Molecular Function for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IBA 21873635
GO:0003730 mRNA 3'-UTR binding IDA 11001948
GO:0005515 protein binding IPI 12505151
GO:0032183 SUMO binding IDA 28695742
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with SERBP1: view
genes like me logo Genes that share phenotypes with SERBP1: view

Animal Model Products

CRISPR Products

miRNA for SERBP1 Gene

miRTarBase miRNAs that target SERBP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERBP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERBP1 Gene

Localization for SERBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERBP1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16879614
GO:0005737 cytoplasm IEA,IDA 16879614
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with SERBP1: view

Pathways & Interactions for SERBP1 Gene

genes like me logo Genes that share pathways with SERBP1: view

Pathways by source for SERBP1 Gene

Gene Ontology (GO) - Biological Process for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030578 PML body organization IDA 28695742
GO:0042981 regulation of apoptotic process IEA --
GO:0043488 regulation of mRNA stability NAS 11001948
genes like me logo Genes that share ontologies with SERBP1: view

No data available for SIGNOR curated interactions for SERBP1 Gene

Drugs & Compounds for SERBP1 Gene

No Compound Related Data Available

Transcripts for SERBP1 Gene

mRNA/cDNA for SERBP1 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERBP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERBP1 Gene

No ASD Table

Relevant External Links for SERBP1 Gene

GeneLoc Exon Structure for
SERBP1

Expression for SERBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERBP1 Gene

Protein differential expression in normal tissues from HIPED for SERBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERBP1 Gene



Protein tissue co-expression partners for SERBP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERBP1

SOURCE GeneReport for Unigene cluster for SERBP1 Gene:

Hs.530412

mRNA Expression by UniProt/SwissProt for SERBP1 Gene:

Q8NC51-PAIRB_HUMAN
Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.

Evidence on tissue expression from TISSUES for SERBP1 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Skin(4.8)
  • Intestine(4.8)
  • Lung(4.8)
  • Blood(4.6)
  • Muscle(4)
  • Kidney(3.5)
  • Eye(3.4)
  • Pancreas(3.2)
  • Bone marrow(2.7)
  • Heart(2.6)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Gall bladder(2.2)
  • Stomach(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with SERBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERBP1 Gene

Orthologs for SERBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERBP1 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SERBP1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SERBP1 30 31
  • 96.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Serbp1 30 17 31
  • 93.35 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SERBP1 31
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SERBP1 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SERBP1 31
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 89 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rda288-prov 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.17049 30
Zebrafish
(Danio rerio)
Actinopterygii serbp1a 31 31
  • 72 (a)
OneToMany
SERBP1 (3 of 3) 31
  • 66 (a)
OneToMany
Dr.383 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10597 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG41503 31
  • 27 (a)
ManyToMany
vig 31
  • 24 (a)
ManyToMany
vig2 31
  • 23 (a)
ManyToMany
Species where no ortholog for SERBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SERBP1 Gene

ENSEMBL:
Gene Tree for SERBP1 (if available)
TreeFam:
Gene Tree for SERBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERBP1: view image

Paralogs for SERBP1 Gene

Paralogs for SERBP1 Gene

(2) SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:

  • PAIRB_HUMAN
  • D3DQ69_HUMAN
  • D3DQ70_HUMAN
genes like me logo Genes that share paralogs with SERBP1: view

Variants for SERBP1 Gene

Additional dbSNP identifiers (rs#s) for SERBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERBP1 Gene

Variant ID Type Subtype PubMed ID
nsv1254 CNV insertion 18451855
nsv461773 CNV loss 19166990
nsv546447 CNV loss 21841781
nsv945985 CNV duplication 23825009

Variation tolerance for SERBP1 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERBP1 Gene

Disorders for SERBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERBP1

genes like me logo Genes that share disorders with SERBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERBP1 Gene

Publications for SERBP1 Gene

  1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton JH … Gelehrter TD (The Journal of biological chemistry 2001) 2 3 4 23
  2. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I … Côté J (Human molecular genetics 2008) 3 4 23
  3. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D … Sehouli J (Gynecologic oncology 2007) 2 3 23
  4. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos TA … Kobarg J (FEBS letters 2003) 3 4 23
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4

Products for SERBP1 Gene

Sources for SERBP1 Gene