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Aliases for SERBP1 Gene
Aliases for SERBP1 Gene
External Ids for SERBP1 Gene
- HGNC: 17860
- Entrez Gene: 26135
- Ensembl: ENSG00000142864
- OMIM: 607378
- UniProtKB: Q8NC51
Previous GeneCards Identifiers for SERBP1 Gene
- GC01M067590
- GC01M067873
- GC01M065983
Summaries for SERBP1 Gene
GeneCards Summary for SERBP1 Gene
SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. Diseases associated with SERBP1 include Ovarian Cancer. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer. Gene Ontology (GO) annotations related to this gene include mRNA 3'-UTR binding. An important paralog of this gene is HABP4.
UniProtKB/Swiss-Prot Summary for SERBP1 Gene
-
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Additional gene information for SERBP1 Gene
- HGNC(17860)
- Entrez Gene(26135)
- Ensembl(ENSG00000142864)
- OMIM(607378)
- UniProtKB(Q8NC51)
- Open Targets Platform(ENSG00000142864)
- Search for SERBP1 at DataMed
- Search for SERBP1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERBP1 Gene
Genomics for SERBP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SERBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SERBP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERBP1
- Top Transcription factor binding sites by QIAGEN in the SERBP1 gene promoter:
-
- AhR
- Arnt
- Bach2
- C/EBPalpha
- E47
- FOXF2
- Ik-1
- Pax-2
- Pax-4a
- Tal-1beta
Genomic Locations for SERBP1 Gene
Genomic Locations for SERBP1 Gene
- chr1:67,407,810-67,430,415
- (GRCh38/hg38)
- Size:
- 22,606 bases
- Orientation:
- Minus strand
- chr1:67,873,493-67,896,123
- (GRCh37/hg19)
- Size:
- 22,631 bases
- Orientation:
- Minus strand
Genomic View for SERBP1 Gene
Genes around SERBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
SERBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERBP1 Gene
Proteins for SERBP1 Gene
-
Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NC51-PAIRB_HUMAN
- Recommended name:
- Plasminogen activator inhibitor 1 RNA-binding protein
- Protein Accession:
- Q8NC51
- Q5VU19
- Q5VU20
- Q5VU22
- Q8WUH0
- Q96SE2
- Q9BTY3
- Q9BUM4
- Q9Y367
- Q9Y4S3
Protein attributes for SERBP1 Gene
- Size:
- 408 amino acids
- Molecular mass:
- 44965 Da
- Quaternary structure:
-
- Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3 (PubMed:12505151, PubMed:18632687). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).
- Miscellaneous:
-
- [Isoform 2]: May be due to a competing acceptor splice site.
- [Isoform 3]: May be due to a competing acceptor splice site.
Protein Expression for SERBP1 Gene
Post-translational modifications for SERBP1 Gene
Other Protein References for SERBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents SERBP1 Antibody / PAI-RBP1 (Mouse Monoclonal)
- Novus Biologicals Antibodies for SERBP1
-
Abcam antibodies for SERBP1
- Invitrogen Antibodies for SERBP1 (AFLGC-SERBP1)
-
Boster Bio Antibodies for SERBP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERBP1
- Sino Biological Antibodies for SERBP1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SERBP1
- Origene Custom Protein Services for SERBP1
- antibodies-online: Show 6 available SERBP1 Proteins ranked by validation data
- Compare Top SERBP1 Proteins
-
Quality Products:
-
Abcam proteins for SERBP1
Assay Products
- antibodies-online: Show 7 available SERBP1 Elisa Kits ranked by validation data
- Compare Top SERBP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SERBP1 Gene
Domains & Families for SERBP1 Gene
Gene Families for SERBP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SERBP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SERBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- SERPINE1 mRNA binding protein 1, isoform CRA_c (D3DQ69_HUMAN)
- SERPINE1 mRNA binding protein 1, isoform CRA_d (D3DQ70_HUMAN)
- SERPINE1 mRNA-binding protein 1 (PAIRB_HUMAN)
- cDNA, FLJ92551, Homo sapiens PAI-1 mRNA-binding protein (PAI-RBP1), mRNA (Q5VU21_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SERBP1 Gene
Function for SERBP1 Gene
Molecular function for SERBP1 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Phenotypes From GWAS Catalog for SERBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA,IBA | 21873635 |
| GO:0003730 | mRNA 3'-UTR binding | IDA | 11001948 |
| GO:0005515 | protein binding | IPI | 12505151 |
| GO:0032183 | SUMO binding | IDA | 28695742 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
Phenotypes for SERBP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERBP1 - Select products 50% OFF >
- * SERBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERBP1
miRNA for SERBP1 Gene
- miRTarBase miRNAs that target SERBP1
-
- hsa-miR-26a-5p (MIRT002315)
- hsa-miR-10a-5p (MIRT025598)
- hsa-miR-16-5p (MIRT031433)
- hsa-miR-93-3p (MIRT038800)
- hsa-miR-652-3p (MIRT039515)
- hsa-miR-625-5p (MIRT039591)
- hsa-miR-615-3p (MIRT039718)
- hsa-miR-505-3p (MIRT040989)
- hsa-miR-328-3p (MIRT043783)
- hsa-miR-374a-5p (MIRT044015)
- hsa-miR-30b-5p (MIRT046130)
- hsa-miR-15b-5p (MIRT046390)
- hsa-miR-100-5p (MIRT048435)
- hsa-miR-27a-3p (MIRT050015)
- hsa-miR-18a-5p (MIRT050709)
- hsa-let-7e-5p (MIRT051499)
- hsa-let-7b-5p (MIRT052014)
- hsa-miR-8485 (MIRT075647)
- hsa-miR-548n (MIRT195721)
- hsa-miR-4699-3p (MIRT285164)
- hsa-miR-6509-5p (MIRT285168)
- hsa-miR-6732-3p (MIRT285169)
- hsa-miR-450b-5p (MIRT285192)
- hsa-miR-6750-3p (MIRT343939)
- hsa-miR-6512-5p (MIRT343949)
- hsa-miR-433-3p (MIRT406144)
- hsa-miR-7154-5p (MIRT406145)
- hsa-miR-4443 (MIRT468569)
- hsa-miR-1273e (MIRT468570)
- hsa-miR-7847-3p (MIRT468571)
- hsa-miR-6880-5p (MIRT468572)
- hsa-miR-6799-5p (MIRT468573)
- hsa-miR-6851-5p (MIRT468574)
- hsa-miR-3689d (MIRT468575)
- hsa-miR-650 (MIRT468576)
- hsa-miR-3612 (MIRT468577)
- hsa-miR-6134 (MIRT468578)
- hsa-miR-6884-5p (MIRT468579)
- hsa-miR-485-5p (MIRT468580)
- hsa-miR-1827 (MIRT468581)
- hsa-miR-4649-3p (MIRT468582)
- hsa-miR-219b-3p (MIRT468583)
- hsa-miR-1247-3p (MIRT468584)
- hsa-miR-6511a-5p (MIRT468585)
- hsa-miR-1910-3p (MIRT468586)
- hsa-miR-2054 (MIRT468587)
- hsa-miR-302f (MIRT468588)
- hsa-miR-6803-5p (MIRT468589)
- hsa-miR-6751-5p (MIRT468590)
- hsa-miR-7109-5p (MIRT468591)
- hsa-miR-4665-5p (MIRT468592)
- hsa-miR-1275 (MIRT468593)
- hsa-miR-4799-5p (MIRT468594)
- hsa-miR-5010-5p (MIRT468595)
- hsa-miR-4525 (MIRT468596)
- hsa-miR-7111-5p (MIRT468597)
- hsa-miR-6870-5p (MIRT468598)
- hsa-miR-4723-5p (MIRT468599)
- hsa-miR-5698 (MIRT468600)
- hsa-miR-8059 (MIRT468601)
- hsa-miR-4471 (MIRT468602)
- hsa-miR-651-5p (MIRT505733)
- hsa-miR-4715-3p (MIRT505734)
- hsa-miR-885-5p (MIRT505735)
- hsa-miR-22-3p (MIRT505736)
- hsa-miR-6802-5p (MIRT510795)
- hsa-miR-6800-5p (MIRT510796)
- hsa-miR-4645-3p (MIRT510797)
- hsa-miR-4790-3p (MIRT510798)
- hsa-miR-622 (MIRT510799)
- hsa-miR-3177-5p (MIRT561623)
- hsa-miR-5093 (MIRT561624)
- hsa-miR-875-3p (MIRT561625)
- hsa-miR-4308 (MIRT561626)
- hsa-miR-511-3p (MIRT561627)
- hsa-miR-504-5p (MIRT561628)
- hsa-miR-1257 (MIRT561629)
- hsa-miR-8060 (MIRT571655)
- hsa-miR-664a-3p (MIRT571656)
- hsa-miR-4703-5p (MIRT571657)
- hsa-miR-3942-5p (MIRT571658)
- hsa-miR-548l (MIRT571659)
- hsa-miR-424-5p (MIRT571660)
- hsa-miR-195-5p (MIRT571661)
- hsa-miR-15a-5p (MIRT571662)
- hsa-miR-497-5p (MIRT571663)
- hsa-miR-6838-5p (MIRT571664)
- hsa-miR-7153-5p (MIRT574442)
- hsa-miR-146b-5p (MIRT574443)
- hsa-miR-146a-5p (MIRT574444)
- hsa-miR-589-5p (MIRT574445)
- hsa-miR-4501 (MIRT574446)
- hsa-miR-362-3p (MIRT609052)
- hsa-miR-329-3p (MIRT609053)
- hsa-miR-513a-5p (MIRT616546)
- hsa-miR-4733-3p (MIRT616547)
- hsa-miR-370-5p (MIRT616548)
- hsa-miR-4764-3p (MIRT638285)
- hsa-miR-510-5p (MIRT638286)
- hsa-miR-548t-3p (MIRT638287)
- hsa-miR-548ap-3p (MIRT638288)
- hsa-miR-548aa (MIRT638289)
- hsa-miR-548x-3p (MIRT638290)
- hsa-miR-548j-3p (MIRT638291)
- hsa-miR-548aq-3p (MIRT638292)
- hsa-miR-548am-3p (MIRT638293)
- hsa-miR-548aj-3p (MIRT638294)
- hsa-miR-548ah-3p (MIRT638295)
- hsa-miR-548ae-3p (MIRT638296)
- hsa-miR-548z (MIRT638297)
- hsa-miR-548h-3p (MIRT638298)
- hsa-miR-548d-3p (MIRT638299)
- hsa-miR-548bb-3p (MIRT638300)
- hsa-miR-548ac (MIRT638301)
- hsa-miR-4462 (MIRT699738)
- hsa-miR-6754-5p (MIRT699739)
- hsa-miR-4441 (MIRT699740)
- hsa-miR-4270 (MIRT699741)
- hsa-miR-211-3p (MIRT699742)
- hsa-miR-7845-5p (MIRT699743)
- hsa-miR-19b-3p (MIRT726627)
- hsa-miR-19a-3p (MIRT726628)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERBP1
- Browse OriGene Inhibitory RNA Products For SERBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERBP1
Clone Products
- Applied Biological Materials (abm): Clones for SERBP1 - Select products 50% OFF >
- * SERBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206038
- MG215890
- MG215905
- MG217462
- MG217478
- MR206038
- MR206038L3
- MR206038L4
- MR215890
- MR215890L3
- MR215890L4
- MR215905
- MR215905L3
- MR215905L4
- MR217462
- MR217462L3
- MR217462L4
- MR217478
- MR217478L3
- MR217478L4
- RC201092
- RC201092L1
- RC201092L2
- RC201092L3
- RC201092L4
- RC203582
- RC203582L1
- RC203582L2
- RC203582L3
- RC203582L4
- RC204527
- RC204527L1
- RC204527L2
- RC204527L3
- RC204527L4
- RC212422
- RC212422L3
- RC212422L4
- RG201092
- RG203582
- RG204527
- RG212422
- RR212350
- RR212350L3
- RR212350L4
- MR206038L3V
- MR206038L4V
- MR215890L3V
- MR215890L4V
- MR215905L3V
- MR215905L4V
- MR217462L3V
- MR217462L4V
- MR217478L3V
- MR217478L4V
- RC201092L1V
- RC201092L2V
- RC201092L3V
- RC201092L4V
- RC203582L1V
- RC203582L2V
- RC203582L3V
- RC203582L4V
- RC204527L1V
- RC204527L2V
- RC204527L3V
- RC204527L4V
- RC212422L3V
- RC212422L4V
- RR212350L3V
- RR212350L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERBP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERBP1 Gene
Localization for SERBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene
- Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 16879614 |
| GO:0005737 | cytoplasm | IEA,IDA | 16879614 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for SERBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis-related network due to altered Notch3 in ovarian cancer | ||
Pathways by source for SERBP1 Gene
1 BioSystems pathway for SERBP1 Gene
Interacting Proteins for SERBP1 Gene
Selected Interacting proteins:
Q8NC51-PAIRB_HUMAN
ENSP00000360034
for SERBP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SERBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030578 | PML body organization | IDA | 28695742 |
| GO:0042981 | regulation of apoptotic process | IEA | -- |
| GO:0043488 | regulation of mRNA stability | NAS | 11001948 |
No data available for SIGNOR curated interactions for SERBP1 Gene
Transcripts for SERBP1 Gene
mRNA/cDNA for SERBP1 Gene
- 4 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361219 2103 nts (view in UCSC)
- ENST00000370990 1621 nts (view in UCSC)
- ENST00000370994 6676 nts (view in UCSC)
- ENST00000370995 3482 nts (view in UCSC)
- ENST00000462814 624 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERBP1 - Select products 50% OFF >
- * SERBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERBP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERBP1
- Browse OriGene Inhibitory RNA Products For SERBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERBP1
Clone Products
- Applied Biological Materials (abm): Clones for SERBP1 - Select products 50% OFF >
- * SERBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206038
- MG215890
- MG215905
- MG217462
- MG217478
- MR206038
- MR206038L3
- MR206038L4
- MR215890
- MR215890L3
- MR215890L4
- MR215905
- MR215905L3
- MR215905L4
- MR217462
- MR217462L3
- MR217462L4
- MR217478
- MR217478L3
- MR217478L4
- RC201092
- RC201092L1
- RC201092L2
- RC201092L3
- RC201092L4
- RC203582
- RC203582L1
- RC203582L2
- RC203582L3
- RC203582L4
- RC204527
- RC204527L1
- RC204527L2
- RC204527L3
- RC204527L4
- RC212422
- RC212422L3
- RC212422L4
- RG201092
- RG203582
- RG204527
- RG212422
- RR212350
- RR212350L3
- RR212350L4
- MR206038L3V
- MR206038L4V
- MR215890L3V
- MR215890L4V
- MR215905L3V
- MR215905L4V
- MR217462L3V
- MR217462L4V
- MR217478L3V
- MR217478L4V
- RC201092L1V
- RC201092L2V
- RC201092L3V
- RC201092L4V
- RC203582L1V
- RC203582L2V
- RC203582L3V
- RC203582L4V
- RC204527L1V
- RC204527L2V
- RC204527L3V
- RC204527L4V
- RC212422L3V
- RC212422L4V
- RR212350L3V
- RR212350L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERBP1
Relevant External Links for SERBP1 Gene
- GeneLoc Exon Structure for
- SERBP1
Expression for SERBP1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERBP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERBP1
SOURCE GeneReport for Unigene cluster for SERBP1 Gene:
Hs.530412mRNA Expression by UniProt/SwissProt for SERBP1 Gene:
Q8NC51-PAIRB_HUMAN
Tissue specificity:
Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
Evidence on tissue expression from TISSUES for SERBP1 Gene
- Nervous system(5)
- Liver(4.9)
- Skin(4.8)
- Intestine(4.8)
- Lung(4.8)
- Blood(4.6)
- Muscle(4)
- Kidney(3.5)
- Eye(3.4)
- Pancreas(3.2)
- Bone marrow(2.7)
- Heart(2.6)
- Lymph node(2.6)
- Spleen(2.6)
- Thyroid gland(2.6)
- Gall bladder(2.2)
- Stomach(2.2)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for SERBP1
-
OriGene qPCR primer pairs and template standards for SERBP1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERBP1 Gene
Orthologs for SERBP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SERBP1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SERBP1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SERBP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Serbp1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SERBP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SERBP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SERBP1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | rda288-prov 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.17049 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | serbp1a 31 31 |
|
OneToMany | |
| SERBP1 (3 of 3) 31 |
|
OneToMany | |||
| Dr.383 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10597 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG41503 31 |
|
ManyToMany | |
| vig 31 |
|
ManyToMany | |||
| vig2 31 |
|
ManyToMany |
- Species where no ortholog for SERBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SERBP1 Gene
- ENSEMBL:
- Gene Tree for SERBP1 (if available)
- TreeFam:
- Gene Tree for SERBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERBP1: view image
Paralogs for SERBP1 Gene
(2) SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:
- PAIRB_HUMAN
- D3DQ69_HUMAN
- D3DQ70_HUMAN
Pseudogenes.org Pseudogenes for SERBP1 Gene
Variants for SERBP1 Gene
Residual Variation Intolerance Score:
18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.61;
13.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SERBP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERBP1 Gene
Disorders for SERBP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cancer |
|
|
Search SERBP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SERBP1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SERBP1 Gene
Publications for SERBP1 Gene
- Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton JH … Gelehrter TD (The Journal of biological chemistry 2001) 2 3 4 23
- TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I … Côté J (Human molecular genetics 2008) 3 4 23
- Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D … Sehouli J (Gynecologic oncology 2007) 2 3 23
- Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos TA … Kobarg J (FEBS letters 2003) 3 4 23
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
ExternalLinks
Products for SERBP1 Gene
- Custom Antibody ServicesOriGene Antibodies for SERBP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SERBP1
- Origene Custom Protein Services for SERBP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERBP1
- Browse OriGene Inhibitory RNA Products For SERBP1
- OriGene qPCR primer pairs for SERBP1
- OriGene qPCR primer pairs and template standards for SERBP1
- OriGene CRISPR knockouts for SERBP1
- MG206038
- MG215890
- MG215905
- MG217462
- MG217478
- MR206038
- MR206038L3
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- MR215890
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- RC212422
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- RR212350
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- MR206038L3V
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- MR217478L3V
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- RC201092L1V
- RC201092L2V
- RC201092L3V
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- RC203582L1V
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- RC204527L2V
- RC204527L3V
- RC204527L4V
- RC212422L3V
- RC212422L4V
- RR212350L3V
- RR212350L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SERBP1
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- Sino Biological Antibodies for SERBP1
- Browse Sino Biological Assays
- Browse Antibodies
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for SERBP1
- Novus Biologicals proteins and lysates for SERBP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SERBP1
- Abcam proteins for SERBP1
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- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SERBP1 (AFLGC-SERBP1)
- VectorBuilder Custom and pre-made DNA vectors for SERBP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SERBP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SERBP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SERBP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SERBP1
- antibodies-online: Show 20 available SERBP1 Antibodies ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SERBP1
- Search Santa Cruz Biotechnology (SCBT) for SERBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERBP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERBP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SERBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERBP1
- Boster Bio Antibodies for SERBP1
- Browse Boster Bio ELISA Kits
Sources for SERBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB