Free for academic non-profit institutions. Other users need a Commercial license
SEPTIN2 (Septin 2) is a Protein Coding gene. Diseases associated with SEPTIN2 include Pineal Region Meningioma and Amyotrophic Neuralgia. Among its related pathways are G-protein signaling RAC1 in cellular process and Shigellosis. An important paralog of this gene is SEPT5-GP1BB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 10321247 |
GO:0005525 | GTP binding | IEA | -- |
GO:0042802 | identical protein binding | IPI | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000145 | exocyst | IEA | -- |
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IEA | -- |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0005634 | nucleus | IDA | 10942595 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Organelle biogenesis and maintenance |
.56
|
|
2 | Bacterial invasion of epithelial cells | ||
3 | Shigellosis | ||
4 | ERK Signaling |
Rho Family GTPases
.61
|
|
5 | Actin Nucleation by ARP-WASP Complex |
RhoA Pathway
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0007224 | smoothened signaling pathway | ISS | -- |
GO:0007283 | spermatogenesis | IEA | -- |
GO:0017157 | regulation of exocytosis | IBA | 21873635 |
GO:0030154 | cell differentiation | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SEPT2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SEPT2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SEPT2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sept2 30 31 |
|
OneToOne | |
Septin2 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Sept2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | SEPT2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SEPT2 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SEPT2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SEPT2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sept2 30 |
|
||
Str.10233 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | XlSeptA 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sept2 30 31 |
|
OneToOne | |
wufb52g01 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5618 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002645 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Sep1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7975 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34185831 | Benign: not provided | 241,337,694(+) |
G/A NM_004404.5(SEPTIN2):c.498G>A (p.Ala166=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2195n106 | CNV | deletion | 24896259 |
esv2307098 | CNV | deletion | 18987734 |
esv2445970 | CNV | deletion | 19546169 |
esv2721993 | CNV | deletion | 23290073 |
esv2721994 | CNV | deletion | 23290073 |
esv3594825 | CNV | gain | 21293372 |
esv3594826 | CNV | gain | 21293372 |
esv3594827 | CNV | gain | 21293372 |
esv3594828 | CNV | gain | 21293372 |
esv3816 | CNV | loss | 18987735 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pineal region meningioma |
|
|
amyotrophic neuralgia |
|
|
brachial plexus neuropathy |
|
|
polycystic kidney disease |
|
|
joubert syndrome 1 |
|
|