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SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]
SEPTIN11 (Septin 11) is a Protein Coding gene. Diseases associated with SEPTIN11 include Chronic Neutrophilic Leukemia and Amyotrophic Neuralgia. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Shigellosis. An important paralog of this gene is SEPTIN6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15485874 |
GO:0005525 | GTP binding | IEA | -- |
GO:0060090 | molecular adaptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | 15485874 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005940 | septin ring | IBA | 21873635 |
GO:0015630 | microtubule cytoskeleton | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Bacterial invasion of epithelial cells | ||
2 | Shigellosis | ||
3 | ERK Signaling |
Rho Family GTPases
.61
|
|
4 | Actin Nucleation by ARP-WASP Complex |
RhoA Pathway
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0034613 | cellular protein localization | IBA | 21873635 |
GO:0050807 | regulation of synapse organization | IEA | -- |
GO:0051301 | cell division | IEA | -- |
GO:0060271 | cilium assembly | IBA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SEPT11 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SEPT11 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SEPT11 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SEPT11 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SEPT11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sept11 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sept11 30 31 |
|
OneToOne | |
Septin11 17 |
|
||||
Chicken (Gallus gallus) |
Aves | SEPT11 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SEPT11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sept11 30 |
|
||
Str.15839 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.25342 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sept8b 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Sep5 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5368 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic neutrophilic leukemia |
|
|
amyotrophic neuralgia |
|
|
brachial plexus neuropathy |
|
|