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Aliases for SEPHS2 Gene

Aliases for SEPHS2 Gene

  • Selenophosphate Synthetase 2 2 3 5
  • Selenide, Water Dikinase 2 3 4
  • Selenophosphate Synthase 2 3 4
  • Selenium Donor Protein 2 3 4
  • EC 2.7.9.3 4 56
  • SPS2 3 4

External Ids for SEPHS2 Gene

Previous GeneCards Identifiers for SEPHS2 Gene

  • GC16M030491
  • GC16M030362
  • GC16M030454
  • GC16M028017
  • GC16M030448
  • GC16M030449
  • GC16M030467
  • GC16M030457
  • GC16M030458
  • GC16M030459
  • GC16M030460
  • GC16M030461
  • GC16M030462
  • GC16M030463
  • GC16M030464

Summaries for SEPHS2 Gene

Entrez Gene Summary for SEPHS2 Gene

  • This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]

GeneCards Summary for SEPHS2 Gene

SEPHS2 (Selenophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins. Gene Ontology (GO) annotations related to this gene include selenide, water dikinase activity. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot for SEPHS2 Gene

Additional gene information for SEPHS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPHS2 Gene

Genomics for SEPHS2 Gene

GeneHancer (GH) Regulatory Elements for SEPHS2 Gene

Promoters and enhancers for SEPHS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEPHS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEPHS2 gene promoter:
  • AML1a
  • c-Fos
  • GATA-1

Genomic Locations for SEPHS2 Gene

Genomic Locations for SEPHS2 Gene
chr16:30,443,625-30,446,181
(GRCh38/hg38)
Size:
2,557 bases
Orientation:
Minus strand
chr16:30,454,952-30,457,502
(GRCh37/hg19)
Size:
2,551 bases
Orientation:
Minus strand

Genomic View for SEPHS2 Gene

Genes around SEPHS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPHS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPHS2 Gene

Proteins for SEPHS2 Gene

  • Protein details for SEPHS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99611-SPS2_HUMAN
    Recommended name:
    Selenide, water dikinase 2
    Protein Accession:
    Q99611
    Secondary Accessions:
    • Q9BUQ2

    Protein attributes for SEPHS2 Gene

    Size:
    448 amino acids
    Molecular mass:
    47305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEPHS2 Gene

Selected DME Specific Peptides for SEPHS2 Gene

Q99611:
  • VTGGQTV
  • TDITGFG
  • VELAYQEAM
  • CDNMLMLL
  • LVQTTDFFYP
  • CVIPLRHGGLSLVQTTD
  • TARIIDKPR
  • TSGGLLI
  • NAHAATD
  • NEFIMPD
  • TGFGILGH
  • GDVLVLTKPLG
  • KYGEGHQAWI

Post-translational modifications for SEPHS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEPHS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SEPHS2 Gene

Gene Families for SEPHS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SEPHS2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53520, highly similar to Selenide, water dikinase 2 (EC 2.7.9.3) (B4E093_HUMAN)
  • Selenophosphate synthase 2 (SPS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99611

UniProtKB/Swiss-Prot:

SPS2_HUMAN :
  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Family:
  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
genes like me logo Genes that share domains with SEPHS2: view

Function for SEPHS2 Gene

Molecular function for SEPHS2 Gene

UniProtKB/Swiss-Prot Function:
Synthesizes selenophosphate from selenide and ATP.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate; Xref=Rhea:RHEA:18737, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:29317, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; EC=2.7.9.3;.

Enzyme Numbers (IUBMB) for SEPHS2 Gene

Phenotypes From GWAS Catalog for SEPHS2 Gene

Gene Ontology (GO) - Molecular Function for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004756 selenide, water dikinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SEPHS2: view
genes like me logo Genes that share phenotypes with SEPHS2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SEPHS2 - Now 50% OFF >
  • * SEPHS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SEPHS2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEPHS2 Gene

Localization for SEPHS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEPHS2 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEPHS2 Gene

Pathways & Interactions for SEPHS2 Gene

genes like me logo Genes that share pathways with SEPHS2: view

Pathways by source for SEPHS2 Gene

2 KEGG pathways for SEPHS2 Gene

Gene Ontology (GO) - Biological Process for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IBA,IEA 21873635
GO:0016259 selenocysteine metabolic process TAS --
GO:0016260 selenocysteine biosynthetic process NAS 8986768
GO:0016310 phosphorylation IEA --
GO:0070329 tRNA seleno-modification IBA 21873635
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for SIGNOR curated interactions for SEPHS2 Gene

Drugs & Compounds for SEPHS2 Gene

(6) Drugs for SEPHS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 216
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Selenocysteine Experimental Pharma 0

(3) Additional Compounds for SEPHS2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Selenophosphate
  • [P(OH)3Se]
  • Selenophosphate
  • Phosphoroselenoate
  • Selenophosphoric acid
  • Monoselenophosphoric acid
25758-66-1, 289702-60-9
Hydrogen selenide
  • [SeH2]
  • H2Se
  • Hydroselenic acid
  • Hydroselenate
  • Dihydrogen monoselenide
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with SEPHS2: view

Transcripts for SEPHS2 Gene

mRNA/cDNA for SEPHS2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for SEPHS2 Gene

Selenophosphate synthetase 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SEPHS2 - Now 50% OFF >
  • * SEPHS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SEPHS2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS2 Gene

No ASD Table

Relevant External Links for SEPHS2 Gene

GeneLoc Exon Structure for
SEPHS2
ECgene alternative splicing isoforms for
SEPHS2

Expression for SEPHS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEPHS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPHS2 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for SEPHS2 Gene

This gene is overexpressed in Skin (13.9), Salivary gland (9.7), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEPHS2 Gene



Protein tissue co-expression partners for SEPHS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEPHS2 Gene:

SEPHS2

SOURCE GeneReport for Unigene cluster for SEPHS2 Gene:

Hs.118725

Evidence on tissue expression from TISSUES for SEPHS2 Gene

  • Liver(4.9)
  • Nervous system(4.6)
  • Muscle(4.4)
  • Skin(4.3)
  • Kidney(3.7)
  • Intestine(3.1)
  • Blood(2.7)
  • Lung(2.5)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SEPHS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEPHS2 Gene

Orthologs for SEPHS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPHS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPHS2 34
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia SEPHS2 34
  • 91.1 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SEPHS2 35 34
  • 88.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sephs2 17 35 34
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Sephs2 34
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SEPHS2 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPHS2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sephs2 34
  • 73.46 (n)
Str.5825 34
zebrafish
(Danio rerio)
Actinopterygii sps2 35 34
  • 68.27 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9452 34
fruit fly
(Drosophila melanogaster)
Insecta SelD 35
  • 65 (a)
ManyToMany
Sps2 35
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea seld-1 35
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8569 35
  • 54 (a)
OneToMany
Cin.11091 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11091 34
Species where no ortholog for SEPHS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPHS2 Gene

ENSEMBL:
Gene Tree for SEPHS2 (if available)
TreeFam:
Gene Tree for SEPHS2 (if available)

Paralogs for SEPHS2 Gene

Paralogs for SEPHS2 Gene

(1) SIMAP similar genes for SEPHS2 Gene using alignment to 4 proteins:

  • SPS2_HUMAN
  • B4E093_HUMAN
  • F5H8F9_HUMAN
  • J3KR58_HUMAN
genes like me logo Genes that share paralogs with SEPHS2: view

Variants for SEPHS2 Gene

Sequence variations from dbSNP and Humsavar for SEPHS2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000619174 -- 30,443,678(-) T/C 3_prime_UTR_variant
rs1000736086 -- 30,446,886(-) G/A/C/T upstream_transcript_variant
rs1001377947 -- 30,447,062(-) T/C upstream_transcript_variant
rs1001913764 -- 30,444,161(-) A/C 3_prime_UTR_variant
rs1001986190 -- 30,447,679(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEPHS2 Gene

Variant ID Type Subtype PubMed ID
nsv1783 CNV deletion 18451855

Variation tolerance for SEPHS2 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEPHS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEPHS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPHS2 Gene

Disorders for SEPHS2 Gene

Additional Disease Information for SEPHS2

No disorders were found for SEPHS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPHS2 Gene

Publications for SEPHS2 Gene

  1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PMID: 8986768) Guimarães MJ … Zlotnik A (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23 58
  2. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. (PMID: 17916946) Xu XM … Hatfield DL (Biological trace element research 2007) 3 23 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PMID: 15534230) Tamura T … Inagaki K (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 23 58
  5. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PMID: 10608886) Lescure A … Krol A (The Journal of biological chemistry 1999) 2 3 58

Products for SEPHS2 Gene

Sources for SEPHS2 Gene

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