This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] See more...

Aliases for SENP8 Gene

Aliases for SENP8 Gene

  • SUMO Peptidase Family Member, NEDD8 Specific 2 3 5
  • NEDD8-Specific Protease 1 2 3 4
  • NEDP1 2 3 4
  • DEN1 2 3 4
  • SUMO/Sentrin Peptidase Family Member, NEDD8 Specific 2 3
  • SUMO/Sentrin Specific Peptidase Family Member 8 2 3
  • Sentrin/SUMO-Specific Protease SENP8 2 4
  • Sentrin-Specific Protease 8 3 4
  • Protease, Cysteine 2 3 4
  • Deneddylase 1 2 3
  • PRSC2 3 4
  • SUMO/Sentrin Specific Protease Family Member 8 2
  • SUMO Sentrin Specific Protease Family Member 8 3
  • Protease, Cysteine, 2 (NEDD8 Specific) 2
  • NEDD8 Specific-Protease Cysteine 2 3
  • Deneddylase-1 4
  • EC 3.4.22.- 4
  • HsT17512 2
  • SENP8 5

External Ids for SENP8 Gene

Previous HGNC Symbols for SENP8 Gene

  • PRSC2

Previous GeneCards Identifiers for SENP8 Gene

  • GC15P068212
  • GC15P065515
  • GC15P070126
  • GC15P070197
  • GC15P072410
  • GC15P049236
  • GC15P072115
  • GC15P072198
  • GC15P072938
  • GC15P074008

Summaries for SENP8 Gene

Entrez Gene Summary for SENP8 Gene

  • This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SENP8 Gene

SENP8 (SUMO Peptidase Family Member, NEDD8 Specific) is a Protein Coding gene. Diseases associated with SENP8 include Kunjin Encephalitis and Kyasanur Forest Disease. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and NEDD8-specific protease activity. An important paralog of this gene is FAM76A.

UniProtKB/Swiss-Prot Summary for SENP8 Gene

  • Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Gene Wiki entry for SENP8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENP8 Gene

Genomics for SENP8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SENP8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENP8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SENP8

Top Transcription factor binding sites by QIAGEN in the SENP8 gene promoter:
  • CREB
  • deltaCREB
  • HNF-1
  • HNF-1A
  • MRF-2
  • Sp1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SENP8 Gene

Latest Assembly
chr15:72,114,258-72,143,692
(GRCh38/hg38)
Size:
29,435 bases
Orientation:
Plus strand

Previous Assembly
chr15:72,406,599-72,436,033
(GRCh37/hg19 by Entrez Gene)
Size:
29,435 bases
Orientation:
Plus strand

chr15:72,406,599-72,433,311
(GRCh37/hg19 by Ensembl)
Size:
26,713 bases
Orientation:
Plus strand

Genomic View for SENP8 Gene

Genes around SENP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP8 Gene

Proteins for SENP8 Gene

  • Protein details for SENP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LD8-SENP8_HUMAN
    Recommended name:
    Sentrin-specific protease 8
    Protein Accession:
    Q96LD8
    Secondary Accessions:
    • Q96QA4

    Protein attributes for SENP8 Gene

    Size:
    212 amino acids
    Molecular mass:
    24107 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP8 Gene

neXtProt entry for SENP8 Gene

Post-translational modifications for SENP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP8 Gene

Domains & Families for SENP8 Gene

Gene Families for SENP8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SENP8 Gene

Suggested Antigen Peptide Sequences for SENP8 Gene

GenScript: Design optimal peptide antigens:
  • Sentrin/SUMO-specific protease SENP8 (SENP8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LD8

UniProtKB/Swiss-Prot:

SENP8_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP8: view

Function for SENP8 Gene

Molecular function for SENP8 Gene

UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=51 nM for Nedd8-AMC {ECO:0000269|PubMed:12759362}; Note=KM for Ub-AMC exceeds 5 uM.;

Enzyme Numbers (IUBMB) for SENP8 Gene

Phenotypes From GWAS Catalog for SENP8 Gene

Gene Ontology (GO) - Molecular Function for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019784 NEDD8-specific protease activity TAS --
genes like me logo Genes that share ontologies with SENP8: view

Phenotypes for SENP8 Gene

genes like me logo Genes that share phenotypes with SENP8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP8

Clone products for research

  • Addgene plasmids for SENP8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP8 Gene

Localization for SENP8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP8 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SENP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SENP8 Gene

Pathways & Interactions for SENP8 Gene

genes like me logo Genes that share pathways with SENP8: view

Pathways by source for SENP8 Gene

1 GeneTex pathway for SENP8 Gene

Gene Ontology (GO) - Biological Process for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SENP8: view

No data available for SIGNOR curated interactions for SENP8 Gene

Drugs & Compounds for SENP8 Gene

(2) Drugs for SENP8 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor 0
ST074946 Pharma 0

(1) ApexBio Compounds for SENP8 Gene

Compound Action Cas Number
PR-619 Deubiquitylating enzymes (DBUs) inhibitor 2645-32-1
genes like me logo Genes that share compounds with SENP8: view

Drug products for research

Transcripts for SENP8 Gene

mRNA/cDNA for SENP8 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP8

Clone products for research

  • Addgene plasmids for SENP8

Alternative Splicing Database (ASD) splice patterns (SP) for SENP8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for SENP8 Gene

GeneLoc Exon Structure for
SENP8

Expression for SENP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP8 Gene

mRNA differential expression in normal tissues according to GTEx for SENP8 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for SENP8 Gene

This gene is overexpressed in Adipocyte (15.8), Bone (11.4), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SENP8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SENP8

SOURCE GeneReport for Unigene cluster for SENP8 Gene:

Hs.513002

mRNA Expression by UniProt/SwissProt for SENP8 Gene:

Q96LD8-SENP8_HUMAN
Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas.

Evidence on tissue expression from TISSUES for SENP8 Gene

  • Kidney(4.4)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SENP8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP8 Gene

Orthologs for SENP8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SENP8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SENP8 29 30
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SENP8 29 30
  • 92.89 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Senp8 29 16 30
  • 90.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Senp8 29
  • 89.62 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia SENP8 30
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SENP8 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SENP8 29 30
  • 75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SENP8 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia senp8 29
  • 58.13 (n)
Zebrafish
(Danio rerio)
Actinopterygii senp8 29 30
  • 60.82 (n)
OneToOne
Dr.19598 29
Fruit Fly
(Drosophila melanogaster)
Insecta Den1 29 30
  • 48.31 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011316 29
  • 47.1 (n)
Worm
(Caenorhabditis elegans)
Secernentea ulp-3 30
  • 27 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G60190 29
  • 46.44 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToOne
Species where no ortholog for SENP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SENP8 Gene

ENSEMBL:
Gene Tree for SENP8 (if available)
TreeFam:
Gene Tree for SENP8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SENP8: view image
Alliance of Genome Resources:
Additional Orthologs for SENP8

Paralogs for SENP8 Gene

Paralogs for SENP8 Gene

genes like me logo Genes that share paralogs with SENP8: view

Variants for SENP8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SENP8 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
984568 Uncertain Significance: Neurodevelopmental abnormality 72,140,229(+) G/A
NM_145204.4(SENP8):c.606G>A (p.Trp202Ter)
NONSENSE
rs930871 -- p.Thr207Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SENP8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SENP8 Gene

Variant ID Type Subtype PubMed ID
esv2675300 CNV deletion 23128226
nsv510665 CNV deletion 20534489
nsv511557 CNV loss 21212237
nsv833051 CNV gain 17160897
nsv976948 CNV duplication 23825009

Variation tolerance for SENP8 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP8
Leiden Open Variation Database (LOVD)
SENP8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP8 Gene

Disorders for SENP8 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SENP8 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search SENP8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SENP8

genes like me logo Genes that share disorders with SENP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP8 Gene

Publications for SENP8 Gene

  1. Identification and characterization of DEN1, a deneddylase of the ULP family. (PMID: 12759362) Gan-Erdene T … Wilkinson KD (The Journal of biological chemistry 2003) 2 3 4 22
  2. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PMID: 15567417) Reverter D … Lima CD (Journal of molecular biology 2005) 3 4 22
  3. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. (PMID: 12730221) Mendoza HM … Hay RT (The Journal of biological chemistry 2003) 2 3 4
  4. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PMID: 12759363) Wu K … Pan ZQ (The Journal of biological chemistry 2003) 3 4 22
  5. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. (PMID: 19328766) Engels IH … Brinker A (Analytical biochemistry 2009) 3 22

Products for SENP8 Gene

Sources for SENP8 Gene