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Aliases for SENP7 Gene

Aliases for SENP7 Gene

  • SUMO1/Sentrin Specific Peptidase 7 2 3 5
  • Sentrin/SUMO-Specific Protease SENP7 4
  • SUMO1/Sentrin Specific Protease 7 2
  • SUMO-1-Specific Protease 2 4
  • EC 3.4.22.- 4
  • KIAA1707 4
  • SUSP2 4
  • SSP2 4

External Ids for SENP7 Gene

Previous GeneCards Identifiers for SENP7 Gene

  • GC03M097695
  • GC03M100470
  • GC03M102324
  • GC03M102364
  • GC03M102525
  • GC03M101043
  • GC03M098411

Summaries for SENP7 Gene

Entrez Gene Summary for SENP7 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP7 Gene

SENP7 (SUMO1/Sentrin Specific Peptidase 7) is a Protein Coding gene. Diseases associated with SENP7 include Malaria and Stargardt Disease. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.

UniProtKB/Swiss-Prot for SENP7 Gene

  • Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Gene Wiki entry for SENP7 Gene

Additional gene information for SENP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP7 Gene

Genomics for SENP7 Gene

GeneHancer (GH) Regulatory Elements for SENP7 Gene

Promoters and enhancers for SENP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I101511 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 566.6 +1.2 1153 3.3 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 ZNF143 SP3 SP5 REST SENP7 ZBTB11 ZBTB11-AS1 NXPE3 GC03M101474
GH03I101683 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 34.2 -171.9 -171921 5.2 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 RPL24 GC03P101686 LOC105374013 ZBTB11-AS1 SENP7 RPS18P5 ZNF90P1 ZBTB11 TFG PDCL3P4
GH03I101560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 24.8 -48.2 -48179 2.3 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 TRMT10C SENP7 NXPE3 RPL24 ZBTB11-AS1 IMPG2 PDCL3P4 PCNP
GH03I101674 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.9 -162.8 -162837 3.7 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZBTB11 ZBTB11-AS1 NXPE3 SENP7 CEP97
GH03I101572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.4 -60.5 -60529 3.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 PCNP NXPE3 SENP7 ZBTB11-AS1 RPS18P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SENP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SENP7 gene promoter:

Genomic Locations for SENP7 Gene

Genomic Locations for SENP7 Gene
189,695 bases
Minus strand

Genomic View for SENP7 Gene

Genes around SENP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP7 Gene

Proteins for SENP7 Gene

  • Protein details for SENP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sentrin-specific protease 7
    Protein Accession:
    Secondary Accessions:
    • A1L3A5
    • A8MW39
    • B7WNW8
    • Q7Z3F4
    • Q96PS5
    • Q9C0F6
    • Q9HBT5

    Protein attributes for SENP7 Gene

    1050 amino acids
    Molecular mass:
    119658 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP7 Gene

    Alternative splice isoforms for SENP7 Gene


neXtProt entry for SENP7 Gene

Post-translational modifications for SENP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP7 Gene

Domains & Families for SENP7 Gene

Gene Families for SENP7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SENP7 Gene

Suggested Antigen Peptide Sequences for SENP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C48 family.
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP7: view

Function for SENP7 Gene

Molecular function for SENP7 Gene

UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Enzyme Numbers (IUBMB) for SENP7 Gene

Phenotypes From GWAS Catalog for SENP7 Gene

Gene Ontology (GO) - Molecular Function for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 20562864
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SENP7: view
genes like me logo Genes that share phenotypes with SENP7: view

Animal Models for SENP7 Gene

MGI Knock Outs for SENP7:

Animal Model Products

miRNA for SENP7 Gene

miRTarBase miRNAs that target SENP7

Clone Products

  • Addgene plasmids for SENP7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SENP7 Gene

Localization for SENP7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP7 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SENP7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SENP7 Gene

Pathways & Interactions for SENP7 Gene

SuperPathways for SENP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with SENP7: view

No data available for Pathways by source and SIGNOR curated interactions for SENP7 Gene

Drugs & Compounds for SENP7 Gene

No Compound Related Data Available

Transcripts for SENP7 Gene

Unigene Clusters for SENP7 Gene

SUMO1/sentrin specific peptidase 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for SENP7

Alternative Splicing Database (ASD) splice patterns (SP) for SENP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP5: -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c

Relevant External Links for SENP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SENP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SENP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP7 Gene

This gene is overexpressed in Plasma (21.5), Peripheral blood mononuclear cells (13.0), Kidney (10.0), Blymphocyte (9.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SENP7 Gene

Protein tissue co-expression partners for SENP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SENP7 Gene:


SOURCE GeneReport for Unigene cluster for SENP7 Gene:


Evidence on tissue expression from TISSUES for SENP7 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SENP7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP7 Gene

Orthologs for SENP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SENP7 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia SENP7 33 34
  • 90.35 (n)
(Bos Taurus)
Mammalia LOC507820 33
  • 88.8 (n)
SENP7 34
  • 80 (a)
(Rattus norvegicus)
Mammalia Senp7 33
  • 81.33 (n)
(Mus musculus)
Mammalia Senp7 33 16 34
  • 81.22 (n)
(Monodelphis domestica)
Mammalia SENP7 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
-- 34
  • 42 (a)
(Gallus gallus)
Aves SENP7 33 34
  • 59.04 (n)
(Anolis carolinensis)
Reptilia SENP7 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia senp7 33
  • 61.02 (n)
(Danio rerio)
Actinopterygii senp7 34
  • 27 (a)
SENP7 (2 of 2) 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12717 35 34
  • 37 (a)
CG10107 34
  • 3 (a)
CG41423 34
  • 1 (a)
(Caenorhabditis elegans)
Secernentea ulp-4 34
  • 4 (a)
ulp-2 34
  • 2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for SENP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP7 Gene

Gene Tree for SENP7 (if available)
Gene Tree for SENP7 (if available)

Paralogs for SENP7 Gene

Paralogs for SENP7 Gene

genes like me logo Genes that share paralogs with SENP7: view

Variants for SENP7 Gene

Sequence variations from dbSNP and Humsavar for SENP7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000000241 -- 101,476,277(-) G/A intron_variant
rs1000000322 -- 101,387,696(-) C/T intron_variant
rs1000009165 -- 101,432,613(-) G/A intron_variant
rs1000015585 -- 101,339,004(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000024397 -- 101,513,342(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SENP7 Gene

Variant ID Type Subtype PubMed ID
dgv779e201 CNV deletion 23290073
esv1929626 CNV deletion 18987734
esv2677578 CNV deletion 23128226
esv2725701 CNV deletion 23290073
esv2725702 CNV deletion 23290073
esv2725704 CNV deletion 23290073
esv3562295 CNV deletion 23714750
esv3562296 CNV deletion 23714750
nsv1003475 CNV gain 25217958
nsv1112386 CNV deletion 24896259
nsv1142365 CNV tandem duplication 24896259
nsv1152266 CNV deletion 26484159
nsv507111 OTHER sequence alteration 20534489
nsv513063 CNV loss 21212237
nsv954350 CNV deletion 24416366
nsv954362 CNV deletion 24416366
nsv967045 CNV duplication 23825009
nsv967046 CNV duplication 23825009
nsv979862 CNV duplication 23825009

Variation tolerance for SENP7 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.15; 90.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP7 Gene

Disorders for SENP7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SENP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malaria, susceptibility to
stargardt disease
  • stargardt disease-1
- elite association - COSMIC cancer census association via MalaCards
Search SENP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SENP7

genes like me logo Genes that share disorders with SENP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP7 Gene

Publications for SENP7 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PMID: 18799455) Lima CD … Reverter D (The Journal of biological chemistry 2008) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SENP7 Gene

  • Addgene plasmids for SENP7

Sources for SENP7 Gene

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