Aliases for SENP7 Gene
External Ids for SENP7 Gene
Previous GeneCards Identifiers for SENP7 Gene
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
GeneCards Summary for SENP7 Gene
SENP7 (SUMO1/Sentrin Specific Peptidase 7) is a Protein Coding gene. Diseases associated with SENP7 include Malaria and Stargardt Disease. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.
UniProtKB/Swiss-Prot for SENP7 Gene
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.