Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore co... See more...

Aliases for SENP6 Gene

Aliases for SENP6 Gene

  • SUMO Specific Peptidase 6 2 3 5
  • SUSP1 2 3 4
  • Sentrin/SUMO-Specific Protease SENP6 3 4
  • SUMO1/Sentrin Specific Peptidase 6 2 3
  • SUMO1/Sentrin Specific Protease 6 2 3
  • Sentrin-Specific Protease 6 3 4
  • SUMO-1-Specific Protease 1 3 4
  • KIAA0797 2 4
  • SSP1 3 4
  • 2810017C20Rik 3
  • EC 3.4.22.- 4
  • SENP6 5

External Ids for SENP6 Gene

Previous GeneCards Identifiers for SENP6 Gene

  • GC06P076308
  • GC06P076367
  • GC06P076311
  • GC06P073510

Summaries for SENP6 Gene

Entrez Gene Summary for SENP6 Gene

  • Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP6 Gene

SENP6 (SUMO Specific Peptidase 6) is a Protein Coding gene. Diseases associated with SENP6 include Schopf-Schulz-Passarge Syndrome and Sarcocystosis. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP7.

UniProtKB/Swiss-Prot Summary for SENP6 Gene

  • Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene Wiki entry for SENP6 Gene

Additional gene information for SENP6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENP6 Gene

Genomics for SENP6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SENP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J075601 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 635.3 +1.3 1334 4.7 PRDM10 ZNF629 TFE3 ZNF692 POLR2A BACH1 ZHX2 LARP7 PRDM1 RBFOX2 SENP6 lnc-FILIP1-4 FILIP1 ENSG00000217488 lnc-FILIP1-2 MYO6
GH06J075490 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 47.9 -107.7 -107651 6.5 PRDM10 ZNF629 ZNF692 BACH1 JUND STAT3 PRDM1 ZNF143 RELA ZSCAN4 FILIP1 piR-48759-266 SENP6 RF00017-5631
GH06J075747 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 21.5 +149.9 149898 7 RNF2 PRDM10 ZNF512 POLR2A ZNF692 BACH1 TARDBP FOXA1 LARP7 ZIC2 MYO6 SENP6 lnc-IMPG1-2 piR-59425-026 IMPG1
GH06J075200 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.4 -396.5 -396543 8.5 CTCF TEAD4 PRDM10 ZNF629 ZNF692 JUND FOXA1 PRDM1 ZNF143 ZIC2 COL12A1 SENP6 TMEM30A piR-50443-320
GH06J075523 Enhancer 1 ENCODE 32.5 -77.1 -77109 1.3 CEBPG CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 NFKBIZ ZNF692 RCOR2 SENP6 FILIP1 RPL26P20 TMEM30A TMEM30A-DT RNU1-34P ENSG00000237174 piR-48820-084 piR-57133-522 RF00017-5631
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENP6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SENP6

Top Transcription factor binding sites by QIAGEN in the SENP6 gene promoter:
  • AML1a
  • CUTL1
  • Egr-1
  • Egr-2
  • GATA-1
  • Nkx2-5
  • Pax-4a
  • Sp1
  • STAT3
  • YY1

Genomic Locations for SENP6 Gene

Genomic Locations for SENP6 Gene
chr6:75,601,509-75,718,281
(GRCh38/hg38)
Size:
116,773 bases
Orientation:
Plus strand
chr6:76,311,225-76,427,997
(GRCh37/hg19)
Size:
116,773 bases
Orientation:
Plus strand

Genomic View for SENP6 Gene

Genes around SENP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP6 Gene

Proteins for SENP6 Gene

  • Protein details for SENP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR1-SENP6_HUMAN
    Recommended name:
    Sentrin-specific protease 6
    Protein Accession:
    Q9GZR1
    Secondary Accessions:
    • A6NNY9
    • O94891
    • Q5VUL3
    • Q5VUL4
    • Q8TBY4
    • Q9UJV5

    Protein attributes for SENP6 Gene

    Size:
    1112 amino acids
    Molecular mass:
    126146 Da
    Quaternary structure:
    • Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
    SequenceCaution:
    • Sequence=BAA34517.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP6 Gene

Post-translational modifications for SENP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP6 Gene

Domains & Families for SENP6 Gene

Gene Families for SENP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SENP6 Gene

Suggested Antigen Peptide Sequences for SENP6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ11355 fis, clone HEMBA1000141, highly similar to Sentrin-specific protease 6 (EC 3.4.22.-) (B3KMM0_HUMAN)
  • Sentrin/SUMO-specific protease SENP6 (SENP6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZR1

UniProtKB/Swiss-Prot:

SENP6_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP6: view

Function for SENP6 Gene

Molecular function for SENP6 Gene

UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Enzyme Numbers (IUBMB) for SENP6 Gene

Phenotypes From GWAS Catalog for SENP6 Gene

Gene Ontology (GO) - Molecular Function for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20212317
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016929 SUMO-specific protease activity IBA 21873635
genes like me logo Genes that share ontologies with SENP6: view
genes like me logo Genes that share phenotypes with SENP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP6 Gene

Localization for SENP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP6 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SENP6: view

Pathways & Interactions for SENP6 Gene

PathCards logo

SuperPathways for SENP6 Gene

No Data Available

Pathways by source for SENP6 Gene

1 GeneTex pathway for SENP6 Gene

UniProtKB/Swiss-Prot Q9GZR1-SENP6_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Gene Ontology (GO) - Biological Process for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016925 protein sumoylation IEA --
GO:0016926 protein desumoylation IMP 20212317
GO:0070646 protein modification by small protein removal IDA 20212317
GO:0090169 regulation of spindle assembly IBA,IMP 20212317
genes like me logo Genes that share ontologies with SENP6: view

No data available for SIGNOR curated interactions for SENP6 Gene

Drugs & Compounds for SENP6 Gene

(1) Drugs for SENP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SENP6: view

Transcripts for SENP6 Gene

mRNA/cDNA for SENP6 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP6

Alternative Splicing Database (ASD) splice patterns (SP) for SENP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SENP6 Gene

GeneLoc Exon Structure for
SENP6

Expression for SENP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Testis (23.1), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SENP6 Gene



Protein tissue co-expression partners for SENP6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SENP6

SOURCE GeneReport for Unigene cluster for SENP6 Gene:

Hs.485784

mRNA Expression by UniProt/SwissProt for SENP6 Gene:

Q9GZR1-SENP6_HUMAN
Tissue specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate.

Evidence on tissue expression from TISSUES for SENP6 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Skin(2.7)
  • Kidney(2.4)
  • Intestine(2.4)
  • Lung(2.4)
  • Spleen(2.3)
  • Heart(2.3)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Muscle(2.1)
  • Thyroid gland(2)
  • Blood(2)
genes like me logo Genes that share expression patterns with SENP6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP6 Gene

Orthologs for SENP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SENP6 30 31
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SENP6 30 31
  • 91.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SENP6 30 31
  • 91.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Senp6 30
  • 86.08 (n)
Mouse
(Mus musculus)
Mammalia Senp6 30 17 31
  • 85.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia SENP6 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SENP6 30 31
  • 73.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SENP6 31
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14557 30
Zebrafish
(Danio rerio)
Actinopterygii senp6a 30 31
  • 53.22 (n)
OneToMany
senp6b 31
  • 34 (a)
OneToMany
Dr.3949 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG12717 31
  • 4 (a)
ManyToMany
CG10107 31
  • 3 (a)
ManyToMany
CG41423 31
  • 1 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ulp-4 31
  • 5 (a)
ManyToMany
ulp-2 31
  • 3 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 31
  • 6 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for SENP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SENP6 Gene

ENSEMBL:
Gene Tree for SENP6 (if available)
TreeFam:
Gene Tree for SENP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SENP6: view image

Paralogs for SENP6 Gene

Paralogs for SENP6 Gene

(1) SIMAP similar genes for SENP6 Gene using alignment to 10 proteins:

  • SENP6_HUMAN
  • B3KMM0_HUMAN
  • D6RG09_HUMAN
  • D6RJH1_HUMAN
  • E7EQN6_HUMAN
  • F8W6D9_HUMAN
  • H0Y4F4_HUMAN
  • H0Y8Y8_HUMAN
  • L8E9U8_HUMAN
  • L8ECG3_HUMAN

Pseudogenes.org Pseudogenes for SENP6 Gene

genes like me logo Genes that share paralogs with SENP6: view

Variants for SENP6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SENP6 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
768102 Benign: not provided 75,647,788(+) G/T SYNONYMOUS_VARIANT
768103 Benign: not provided 75,663,286(+) G/A SYNONYMOUS_VARIANT
783467 Benign: not provided 75,678,807(+) A/T INTRON_VARIANT
rs34451237 Uncertain Significance: not provided 75,621,592(+) A/G MISSENSE_VARIANT
rs1061347 - p.Glu637Lys

Additional dbSNP identifiers (rs#s) for SENP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for SENP6 Gene

Variant ID Type Subtype PubMed ID
esv2672891 CNV deletion 23128226
esv3540004 CNV deletion 23714750
esv3576179 CNV gain 25503493
esv3609579 CNV loss 21293372
nsv1032961 CNV gain 25217958
nsv1125881 CNV tandem duplication 24896259
nsv1148796 CNV insertion 26484159
nsv522814 CNV loss 19592680

Variation tolerance for SENP6 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP6 Gene

Disorders for SENP6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SENP6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
schopf-schulz-passarge syndrome
  • ssps
sarcocystosis
  • sarcosporidiosis
- elite association - COSMIC cancer census association via MalaCards
Search SENP6 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SENP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP6 Gene

Publications for SENP6 Gene

  1. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PMID: 17000875) Mukhopadhyay D … Dasso M (The Journal of cell biology 2006) 3 4 23
  2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. (PMID: 10799485) Kim KI … Chung CH (The Journal of biological chemistry 2000) 3 4 23
  3. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. (PMID: 21148299) Hattersley N … Hay RT (Molecular biology of the cell 2011) 3 4
  4. The SUMO protease SENP6 is essential for inner kinetochore assembly. (PMID: 20212317) Mukhopadhyay D … Dasso M (The Journal of cell biology 2010) 3 4
  5. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PMID: 17704809) Cheng Z … Yao X (Oncogene 2008) 3 4

Products for SENP6 Gene

Sources for SENP6 Gene