Aliases for SENP5 Gene
External Ids for SENP5 Gene
Previous GeneCards Identifiers for SENP5 Gene
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
GeneCards Summary for SENP5 Gene
SENP5 (SUMO Specific Peptidase 5) is a Protein Coding gene. Diseases associated with SENP5 include 3-Methylglutaconic Aciduria, Type Iii. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP3.
UniProtKB/Swiss-Prot Summary for SENP5 Gene
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.