The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have is... See more...

Aliases for SENP5 Gene

Aliases for SENP5 Gene

  • SUMO Specific Peptidase 5 2 3 5
  • Sentrin/SUMO-Specific Protease SENP5 3 4
  • SUMO1/Sentrin Specific Peptidase 5 2 3
  • SUMO1/Sentrin Specific Protease 5 2 3
  • Sentrin-Specific Protease 5 3 4
  • EC 3.4.22.- 4
  • EC 3.4.22 50
  • MGC27076 2
  • SENP5 5

External Ids for SENP5 Gene

Previous GeneCards Identifiers for SENP5 Gene

  • GC03P197922
  • GC03P198083
  • GC03P196594
  • GC03P193894

Summaries for SENP5 Gene

Entrez Gene Summary for SENP5 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP5 Gene

SENP5 (SUMO Specific Peptidase 5) is a Protein Coding gene. Diseases associated with SENP5 include 3-Methylglutaconic Aciduria, Type Iii. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot Summary for SENP5 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENP5 Gene

Genomics for SENP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SENP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SENP5

Genomic Locations for SENP5 Gene

Latest Assembly
chr3:196,867,856-196,934,714
(GRCh38/hg38)
Size:
66,859 bases
Orientation:
Plus strand

Previous Assembly
chr3:196,594,791-196,661,585
(GRCh37/hg19 by Entrez Gene)
Size:
66,795 bases
Orientation:
Plus strand

chr3:196,594,727-196,661,585
(GRCh37/hg19 by Ensembl)
Size:
66,859 bases
Orientation:
Plus strand

Genomic View for SENP5 Gene

Genes around SENP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP5 Gene

Proteins for SENP5 Gene

  • Protein details for SENP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HI0-SENP5_HUMAN
    Recommended name:
    Sentrin-specific protease 5
    Protein Accession:
    Q96HI0
    Secondary Accessions:
    • B4DY82
    • Q96SA5

    Protein attributes for SENP5 Gene

    Size:
    755 amino acids
    Molecular mass:
    86693 Da
    Quaternary structure:
    • Interacts with CCAR2.
    SequenceCaution:
    • Sequence=AAK69630.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP5 Gene

Selected DME Specific Peptides for SENP5 Gene

Q96HI0:
  • KVHFFNSFF
  • GQNWLNDQV
  • FVLQYCK
  • LLLIPIHLEVHWSLI

Post-translational modifications for SENP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for SENP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for SENP5

Domains & Families for SENP5 Gene

Gene Families for SENP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SENP5 Gene

InterPro:
Blocks:
  • SUMO/Sentrin/Ubl1 specific protease

Suggested Antigen Peptide Sequences for SENP5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56806, highly similar to Sentrin-specific protease 5 (EC 3.4.22.-) (B4DY82_HUMAN)
  • Sentrin/SUMO-specific protease SENP5 (SENP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HI0

UniProtKB/Swiss-Prot:

SENP5_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP5: view

Function for SENP5 Gene

Molecular function for SENP5 Gene

UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Enzyme Numbers (IUBMB) for SENP5 Gene

Phenotypes From GWAS Catalog for SENP5 Gene

Gene Ontology (GO) - Molecular Function for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21217774
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016929 SUMO-specific protease activity IBA 21873635
genes like me logo Genes that share ontologies with SENP5: view
genes like me logo Genes that share phenotypes with SENP5: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SENP5

miRNA for SENP5 Gene

miRTarBase miRNAs that target SENP5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP5 Gene

Localization for SENP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP5 gene
Compartment Confidence
nucleus 5
plasma membrane 4
mitochondrion 3
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Centrosome (1)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SENP5: view

Pathways & Interactions for SENP5 Gene

genes like me logo Genes that share pathways with SENP5: view

Pathways by source for SENP5 Gene

Gene Ontology (GO) - Biological Process for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0016925 protein sumoylation TAS --
GO:0016926 protein desumoylation IEA,IBA 21873635
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SENP5: view

No data available for SIGNOR curated interactions for SENP5 Gene

Drugs & Compounds for SENP5 Gene

No Compound Related Data Available

Transcripts for SENP5 Gene

mRNA/cDNA for SENP5 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SENP5

Alternative Splicing Database (ASD) splice patterns (SP) for SENP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for SENP5 Gene

GeneLoc Exon Structure for
SENP5

Expression for SENP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

Protein differential expression in normal tissues from HIPED for SENP5 Gene

This gene is overexpressed in Spleen (41.0) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SENP5 Gene



Protein tissue co-expression partners for SENP5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SENP5

SOURCE GeneReport for Unigene cluster for SENP5 Gene:

Hs.240770

Evidence on tissue expression from TISSUES for SENP5 Gene

  • Intestine(3.5)
  • Skin(2.8)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with SENP5: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP5 Gene

Orthologs for SENP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SENP5 29 30
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SENP5 29 30
  • 92.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SENP5 29 30
  • 91.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Senp5 29
  • 87.81 (n)
Mouse
(Mus musculus)
Mammalia Senp5 29 16 30
  • 87.57 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SENP5 30
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SENP5 30
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SENP5 29 30
  • 68.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SENP5 30
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33591 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.4871 29
Zebrafish
(Danio rerio)
Actinopterygii senp5 30
  • 39 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13692 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG32110 30
  • 22 (a)
ManyToMany
CG11023 30
  • 19 (a)
ManyToMany
Ulp1 30
  • 8 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ulp-1 30
  • 15 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 30
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToMany
Species where no ortholog for SENP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SENP5 Gene

ENSEMBL:
Gene Tree for SENP5 (if available)
TreeFam:
Gene Tree for SENP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SENP5: view image
Alliance of Genome Resources:
Additional Orthologs for SENP5

Paralogs for SENP5 Gene

Paralogs for SENP5 Gene

(2) SIMAP similar genes for SENP5 Gene using alignment to 5 proteins:

  • SENP5_HUMAN
  • B4DY82_HUMAN
  • C9JHT8_HUMAN
  • H7C2F8_HUMAN
  • H7C424_HUMAN
genes like me logo Genes that share paralogs with SENP5: view

Variants for SENP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SENP5 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs34326043 Benign: not provided 196,886,230(+) G/A
NM_152699.5(SENP5):c.1049G>A (p.Gly350Asp)
MISSENSE
rs34707496 Benign: not provided 196,885,322(+) A/G
NM_152699.5(SENP5):c.141A>G (p.Pro47=)
SYNONYMOUS
rs35434690 Benign: not provided 196,885,429(+) A/Gp.Asn83Ser
NM_152699.5(SENP5):c.248A>G (p.Asn83Ser)
MISSENSE
rs559835961 Benign: not provided 196,930,805(+) T/C
NM_152699.5(SENP5):c.2158-8T>C
INTRON
rs34251880 -- p.Leu340Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SENP5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SENP5 Gene

Variant ID Type Subtype PubMed ID
dgv5036n100 CNV gain 25217958
dgv87n16 CNV insertion 17901297
esv2763775 CNV gain+loss 21179565
esv3304873 CNV mobile element insertion 20981092
esv3342001 CNV insertion 20981092
esv3424685 CNV insertion 20981092
esv3436933 CNV insertion 20981092
esv3599293 CNV gain 21293372
nsv1001045 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1117365 CNV tandem duplication 24896259
nsv1125402 OTHER inversion 24896259
nsv593086 CNV loss 21841781
nsv829829 CNV loss 17160897
nsv956261 CNV insertion 24416366

Variation tolerance for SENP5 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP5
Leiden Open Variation Database (LOVD)
SENP5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP5 Gene

Disorders for SENP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SENP5 Gene - From: COP

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type iii
  • mgca3
- elite association - COSMIC cancer census association via MalaCards
Search SENP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SENP5

genes like me logo Genes that share disorders with SENP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP5 Gene

Publications for SENP5 Gene

  1. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PMID: 16608850) Gong L … Yeh ET (The Journal of biological chemistry 2006) 3 4 22
  2. The SUMO-specific protease SENP5 is required for cell division. (PMID: 16738315) Di Bacco A … Gill G (Molecular and cellular biology 2006) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Ubiquitin-like proteins: new wines in new bottles. (PMID: 10806345) Yeh ET … Kamitani T (Gene 2000) 3 4
  5. Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. (PMID: 33211757) Zhang X … Liu X (PloS one 2020) 3

Products for SENP5 Gene

Sources for SENP5 Gene