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Aliases for SENP5 Gene

Aliases for SENP5 Gene

  • SUMO1/Sentrin Specific Peptidase 5 2 3 5
  • Sentrin/SUMO-Specific Protease SENP5 4
  • SUMO1/Sentrin Specific Protease 5 2
  • EC 3.4.22.- 4
  • EC 3.4.22 56

External Ids for SENP5 Gene

Previous GeneCards Identifiers for SENP5 Gene

  • GC03P197922
  • GC03P198083
  • GC03P196594
  • GC03P193894

Summaries for SENP5 Gene

Entrez Gene Summary for SENP5 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP5 Gene

SENP5 (SUMO1/Sentrin Specific Peptidase 5) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot for SENP5 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Additional gene information for SENP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP5 Gene

Genomics for SENP5 Gene

GeneHancer (GH) Regulatory Elements for SENP5 Gene

Promoters and enhancers for SENP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196866 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 190 2.5 HDGF SMAD1 ARNT ARID4B SIN3A YY1 POLR2B ZNF207 ZNF143 SP5 SENP5 NCBP2-AS2 RPL36P7 NCBP2 NCBP2-AS1 CEP19 GC03M196873
GH03I196316 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.3 -549.8 -549775 2.8 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B E2F8 ZNF143 ZNF207 TCTEX1D2 ENSG00000272741 TM4SF19-AS1 SDHAP1 SDHAP2 UBXN7 LINC00969 RNU6ATAC24P RNF168 ENSG00000271662
GH03I196938 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 +74.5 74521 7.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC NCBP2-AS2 NCBP2 PIGZ SENP5 NCBP2-AS1
GH03I196078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -786.9 -786874 4.4 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 TFRC SDHAP1 SDHAP2 LINC00969 UBXN7 ACAP2 ENSG00000230732 RNU6ATAC24P MUC4 SENP5
GH03I197553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.6 +687.3 687280 2.5 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B BRCA1 GLIS2 ZNF143 RUNX3 DEK BDH1 MELTF-AS1 ENSG00000249626 SENP5 LOC220729 GC03P197515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SENP5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SENP5 Gene

Genomic Locations for SENP5 Gene
chr3:196,867,856-196,934,714
(GRCh38/hg38)
Size:
66,859 bases
Orientation:
Plus strand
chr3:196,594,727-196,661,585
(GRCh37/hg19)

Genomic View for SENP5 Gene

Genes around SENP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP5 Gene

Proteins for SENP5 Gene

  • Protein details for SENP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HI0-SENP5_HUMAN
    Recommended name:
    Sentrin-specific protease 5
    Protein Accession:
    Q96HI0
    Secondary Accessions:
    • B4DY82
    • Q96SA5

    Protein attributes for SENP5 Gene

    Size:
    755 amino acids
    Molecular mass:
    86693 Da
    Quaternary structure:
    • Interacts with CCAR2.
    SequenceCaution:
    • Sequence=AAK69630.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP5 Gene

Selected DME Specific Peptides for SENP5 Gene

Q96HI0:
  • KVHFFNSFF
  • GQNWLNDQV
  • FVLQYCK
  • LLLIPIHLEVHWSLI

Post-translational modifications for SENP5 Gene

No Post-translational modifications

Domains & Families for SENP5 Gene

Gene Families for SENP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SENP5 Gene

Suggested Antigen Peptide Sequences for SENP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HI0

UniProtKB/Swiss-Prot:

SENP5_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP5: view

Function for SENP5 Gene

Molecular function for SENP5 Gene

UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Enzyme Numbers (IUBMB) for SENP5 Gene

Phenotypes From GWAS Catalog for SENP5 Gene

Gene Ontology (GO) - Molecular Function for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0005515 protein binding IPI 21217774
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SENP5: view
genes like me logo Genes that share phenotypes with SENP5: view

Clone Products

  • Addgene plasmids for SENP5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP5 Gene

Localization for SENP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP5 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SENP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SENP5 Gene

Pathways & Interactions for SENP5 Gene

genes like me logo Genes that share pathways with SENP5: view

Pathways by source for SENP5 Gene

Gene Ontology (GO) - Biological Process for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0016925 protein sumoylation TAS --
GO:0016926 protein desumoylation IBA,IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SENP5: view

No data available for SIGNOR curated interactions for SENP5 Gene

Drugs & Compounds for SENP5 Gene

No Compound Related Data Available

Transcripts for SENP5 Gene

Unigene Clusters for SENP5 Gene

SUMO1/sentrin specific peptidase 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for SENP5

Alternative Splicing Database (ASD) splice patterns (SP) for SENP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for SENP5 Gene

GeneLoc Exon Structure for
SENP5
ECgene alternative splicing isoforms for
SENP5

Expression for SENP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SENP5 Gene

Protein differential expression in normal tissues from HIPED for SENP5 Gene

This gene is overexpressed in Spleen (41.0) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SENP5 Gene



Protein tissue co-expression partners for SENP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SENP5 Gene:

SENP5

SOURCE GeneReport for Unigene cluster for SENP5 Gene:

Hs.240770

Evidence on tissue expression from TISSUES for SENP5 Gene

  • Intestine(3.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SENP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP5 Gene

Orthologs for SENP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP5 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia SENP5 33 34
  • 92.93 (n)
cow
(Bos Taurus)
Mammalia SENP5 33 34
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Senp5 33
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Senp5 33 16 34
  • 87.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SENP5 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SENP5 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP5 33 34
  • 68.86 (n)
lizard
(Anolis carolinensis)
Reptilia SENP5 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4871 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33591 33
zebrafish
(Danio rerio)
Actinopterygii senp5 34
  • 39 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13692 33
fruit fly
(Drosophila melanogaster)
Insecta CG32110 34
  • 22 (a)
ManyToMany
CG11023 34
  • 19 (a)
ManyToMany
Ulp1 34
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-1 34
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for SENP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP5 Gene

ENSEMBL:
Gene Tree for SENP5 (if available)
TreeFam:
Gene Tree for SENP5 (if available)

Paralogs for SENP5 Gene

Paralogs for SENP5 Gene

(2) SIMAP similar genes for SENP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SENP5: view

Variants for SENP5 Gene

Sequence variations from dbSNP and Humsavar for SENP5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000014043 -- 196,907,401(+) A/G intron_variant
rs1000045566 -- 196,876,225(+) A/G intron_variant
rs1000050242 -- 196,921,583(+) T/G intron_variant
rs1000085752 -- 196,907,765(+) A/G intron_variant
rs1000153976 -- 196,886,020(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SENP5 Gene

Variant ID Type Subtype PubMed ID
nsv956261 CNV insertion 24416366
nsv829829 CNV loss 17160897
nsv593086 CNV loss 21841781
nsv1125402 OTHER inversion 24896259
nsv1117365 CNV tandem duplication 24896259
nsv1003135 CNV gain 25217958
nsv1001045 CNV gain 25217958
esv3599293 CNV gain 21293372
esv3436933 CNV insertion 20981092
esv3424685 CNV insertion 20981092
esv3342001 CNV insertion 20981092
esv3304873 CNV mobile element insertion 20981092
esv2763775 CNV gain+loss 21179565
dgv87n16 CNV insertion 17901297
dgv5036n100 CNV gain 25217958

Variation tolerance for SENP5 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP5 Gene

Disorders for SENP5 Gene

Additional Disease Information for SENP5

No disorders were found for SENP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SENP5 Gene

Publications for SENP5 Gene

  1. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PMID: 16608850) Gong L … Yeh ET (The Journal of biological chemistry 2006) 3 4 22 58
  2. The SUMO-specific protease SENP5 is required for cell division. (PMID: 16738315) Di Bacco A … Gill G (Molecular and cellular biology 2006) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Ubiquitin-like proteins: new wines in new bottles. (PMID: 10806345) Yeh ET … Kamitani T (Gene 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SENP5 Gene

  • Addgene plasmids for SENP5

Sources for SENP5 Gene

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