SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004] See more...

Aliases for SENP2 Gene

Aliases for SENP2 Gene

  • SUMO Specific Peptidase 2 2 3 5
  • SUMO1/Sentrin/SMT3 Specific Peptidase 2 2 3
  • SUMO1/Sentrin/SMT3 Specific Protease 2 2 3
  • Sentrin/SUMO-Specific Protease SENP2 3 4
  • Sentrin (SUMO1) Specific Peptidase 2 2 3
  • SMT3-Specific Isopeptidase 2 3 4
  • Sentrin-Specific Protease 2 3 4
  • EC 3.4.22.68 52
  • EC 3.4.22.- 4
  • EC 3.4.22 52
  • KIAA1331 4
  • SMT3IP2 3
  • Smt3ip2 4
  • AXAM2 3
  • Axam2 4

External Ids for SENP2 Gene

Previous GeneCards Identifiers for SENP2 Gene

  • GC03P182095
  • GC03M186470
  • GC03P186706
  • GC03P186624
  • GC03P186786
  • GC03P185301
  • GC03P182713

Summaries for SENP2 Gene

Entrez Gene Summary for SENP2 Gene

  • SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

GeneCards Summary for SENP2 Gene

SENP2 (SUMO Specific Peptidase 2) is a Protein Coding gene. Diseases associated with SENP2 include Myopathy, X-Linked, With Postural Muscle Atrophy. Among its related pathways are Metabolism of proteins and SUMOylation. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP1.

UniProtKB/Swiss-Prot Summary for SENP2 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

Gene Wiki entry for SENP2 Gene

Additional gene information for SENP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENP2 Gene

Genomics for SENP2 Gene

GeneHancer (GH) Regulatory Elements for SENP2 Gene

Promoters and enhancers for SENP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J185581 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.9 1871 6.5 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 USF1 POLR2G SP1 PHF8 SENP2 VPS8 lnc-MAP3K13-9 RPL34P10
GH03J185548 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.8 -28.4 -28374 11.1 ZBTB40 ZNF217 CTCF SIN3A TCF12 GTF2E2 JUND PHB2 FOS ZNF10 LIPH SENP2 TMEM41A VPS8 piR-40154-127
GH03J185536 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 -45.0 -44995 2.6 ZNF217 NRF1 TCF12 SP1 ZNF639 ZIC2 ZBTB10 ZBTB11 ZNF423 TRIM28 SENP2 TMEM41A LIPH piR-45035-136
GH03J185543 Enhancer 1 ENCODE dbSUPER 11.9 -36.6 -36597 4.7 ZNF217 CTCF TCF12 SP1 RELA MEF2C RCOR1 ZBTB7A CTBP1 FOXA2 SENP2 LIPH piR-45035-136
GH03J185575 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -7.1 -7095 1.6 CTCF ZNF10 REST RAD21 CTBP1 TRIM22 ZNF341 NCOR1 WT1 SMC3 TMEM41A piR-40154-128 SENP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SENP2

Top Transcription factor binding sites by QIAGEN in the SENP2 gene promoter:
  • AhR
  • Arnt
  • Evi-1
  • GATA-1
  • GATA-2
  • GATA-3
  • ITF-2
  • Pax-3
  • RFX1
  • Tal-1beta

Genomic Locations for SENP2 Gene

Genomic Locations for SENP2 Gene
chr3:185,582,496-185,633,551
(GRCh38/hg38)
Size:
51,056 bases
Orientation:
Plus strand
chr3:185,300,284-185,351,339
(GRCh37/hg19)
Size:
51,056 bases
Orientation:
Plus strand

Genomic View for SENP2 Gene

Genes around SENP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP2 Gene

Proteins for SENP2 Gene

  • Protein details for SENP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC62-SENP2_HUMAN
    Recommended name:
    Sentrin-specific protease 2
    Protein Accession:
    Q9HC62
    Secondary Accessions:
    • B4DQ42
    • Q8IW97
    • Q96SR2
    • Q9P2L5

    Protein attributes for SENP2 Gene

    Size:
    589 amino acids
    Molecular mass:
    67855 Da
    Quaternary structure:
    • Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for SENP2 Gene

    Alternative splice isoforms for SENP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP2 Gene

Selected DME Specific Peptides for SENP2 Gene

Q9HC62:
  • DLNLLEWTH
  • MVWEILH
  • QMDTLKTKGW
  • GYQAVKRWTK
  • NGSDCGMF
  • WLNDEVINFYMNL

Post-translational modifications for SENP2 Gene

  • Polyubiquitinated; which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SENP2

Domains & Families for SENP2 Gene

Gene Families for SENP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SENP2 Gene

Blocks:
  • SUMO/Sentrin/Ubl1 specific protease
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SENP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56470, highly similar to Sentrin-specific protease 2 (EC 3.4.22.-) (B4DQ42_HUMAN)
  • Sentrin/SUMO-specific protease SENP2 (SENP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HC62

UniProtKB/Swiss-Prot:

SENP2_HUMAN :
  • The N-terminus is necessary and sufficient for nuclear envelope targeting.
  • Belongs to the peptidase C48 family.
Domain:
  • The N-terminus is necessary and sufficient for nuclear envelope targeting.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP2: view

Function for SENP2 Gene

Molecular function for SENP2 Gene

UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

Enzyme Numbers (IUBMB) for SENP2 Gene

Phenotypes From GWAS Catalog for SENP2 Gene

Gene Ontology (GO) - Molecular Function for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11896061
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with SENP2: view
genes like me logo Genes that share phenotypes with SENP2: view

Animal Models for SENP2 Gene

MGI Knock Outs for SENP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP2

miRNA for SENP2 Gene

miRTarBase miRNAs that target SENP2

Clone Products

  • Addgene plasmids for SENP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SENP2 Gene

Localization for SENP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP2 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269 PubMed:16738331}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005643 nuclear pore IEA,IDA 12192048
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SENP2: view

Pathways & Interactions for SENP2 Gene

genes like me logo Genes that share pathways with SENP2: view

Pathways by source for SENP2 Gene

Gene Ontology (GO) - Biological Process for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006508 proteolysis IEA --
GO:0007507 heart development IEA --
GO:0009950 dorsal/ventral axis specification IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SENP2: view

No data available for SIGNOR curated interactions for SENP2 Gene

Drugs & Compounds for SENP2 Gene

(1) Drugs for SENP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor 0

(1) ApexBio Compounds for SENP2 Gene

Compound Action Cas Number
NSC 632839 hydrochloride Isopeptidases inhibitor 157654-67-6
genes like me logo Genes that share compounds with SENP2: view

Drug Products

Transcripts for SENP2 Gene

mRNA/cDNA for SENP2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for SENP2

Alternative Splicing Database (ASD) splice patterns (SP) for SENP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10: -
SP11:

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SENP2 Gene

GeneLoc Exon Structure for
SENP2

Expression for SENP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP2 Gene

Protein differential expression in normal tissues from HIPED for SENP2 Gene

This gene is overexpressed in Placenta (32.7), Testis (20.8), and Ovary (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SENP2 Gene



Protein tissue co-expression partners for SENP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SENP2

SOURCE GeneReport for Unigene cluster for SENP2 Gene:

Hs.401388

Evidence on tissue expression from TISSUES for SENP2 Gene

  • Nervous system(4.8)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SENP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP2 Gene

Orthologs for SENP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP2 31 30
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SENP2 31 30
  • 93.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SENP2 31 30
  • 92.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp2 30
  • 88.47 (n)
mouse
(Mus musculus)
Mammalia Senp2 17 31 30
  • 88.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SENP2 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP2 31 30
  • 58.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP2 31
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii senp2 31 30
  • 46.51 (n)
OneToOne
wufb78c01 30
fruit fly
(Drosophila melanogaster)
Insecta CG32110 31
  • 27 (a)
ManyToMany
CG11023 31 32
  • 24 (a)
ManyToMany
Ulp1 31 32
  • 10 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T10F2.3 32
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 31
  • 18 (a)
OneToMany
Species where no ortholog for SENP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP2 Gene

ENSEMBL:
Gene Tree for SENP2 (if available)
TreeFam:
Gene Tree for SENP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SENP2: view image

Paralogs for SENP2 Gene

Paralogs for SENP2 Gene

(2) SIMAP similar genes for SENP2 Gene using alignment to 9 proteins:

  • SENP2_HUMAN
  • B4DQ42_HUMAN
  • C9IYB7_HUMAN
  • F8WCX8_HUMAN
  • F8WED6_HUMAN
  • F8WED7_HUMAN
  • F8WET6_HUMAN
  • H7C1A0_HUMAN
  • J3KQD2_HUMAN
genes like me logo Genes that share paralogs with SENP2: view

Variants for SENP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SENP2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
709755 Benign: not provided 185,609,340(+) A/G MISSENSE_VARIANT
rs6762208 - p.Thr301Lys

Additional dbSNP identifiers (rs#s) for SENP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SENP2 Gene

Variant ID Type Subtype PubMed ID
nsv1139186 CNV deletion 24896259
nsv4148 CNV insertion 18451855

Variation tolerance for SENP2 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.26; 88.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SENP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP2 Gene

Disorders for SENP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SENP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy, x-linked, with postural muscle atrophy
  • xmpma
- elite association - COSMIC cancer census association via MalaCards
Search SENP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SENP2

genes like me logo Genes that share disorders with SENP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP2 Gene

Publications for SENP2 Gene

  1. Association of the human SUMO-1 protease SENP2 with the nuclear pore. (PMID: 11896061) Hang J … Dasso M (The Journal of biological chemistry 2002) 2 3 4 54
  2. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. (PMID: 11489887) Nishida T … Yasuda H (The Journal of biological chemistry 2001) 2 3 23 54
  3. SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L … Kumar R (The Journal of biological chemistry 2011) 3 4 54
  4. Control of adipogenesis by the SUMO-specific protease SENP2. (PMID: 20194620) Chung SS … Park KS (Molecular and cellular biology 2010) 3 4 54
  5. Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. (PMID: 16738331) Itahana Y … Zhang Y (Molecular and cellular biology 2006) 3 4 54

Products for SENP2 Gene

Sources for SENP2 Gene