Aliases for SENP2 Gene
External Ids for SENP2 Gene
Previous GeneCards Identifiers for SENP2 Gene
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
GeneCards Summary for SENP2 Gene
SENP2 (SUMO Specific Peptidase 2) is a Protein Coding gene. Diseases associated with SENP2 include Myopathy, X-Linked, With Postural Muscle Atrophy. Among its related pathways are Metabolism of proteins and SUMOylation. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP1.
UniProtKB/Swiss-Prot Summary for SENP2 Gene
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).