Aliases for SENCR Gene

Subcategory (RNA class) for SENCR Gene

lncRNA

Quality Score for this RNA gene is

16

Aliases for SENCR Gene

  • Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA 2 3 5
  • Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated Long Non-Coding RNA 2 3
  • FLI1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • SENCR 2 170
  • FLI1 Antisense RNA 1 2
  • NONHSAG010021 94
  • HSALNG0088110 169
  • FLI1-AS1 3
  • LncRNA9 3

External Ids for SENCR Gene

Previous HGNC Symbols for SENCR Gene

  • FLI1-AS1

Previous GeneCards Identifiers for SENCR Gene

  • GC11M128564

Summaries for SENCR Gene

GeneCards Summary for SENCR Gene

SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for SENCR Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENCR Gene

Genomics for SENCR Gene

GeneHancer (GH) Regulatory Elements for SENCR Gene

Promoters and enhancers for SENCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J128692 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.9 933 7.4 ZBTB6 POLR2A HDAC2 ZNF362 JUND MYC ETV6 MAX ZNF652 NKRF SENCR FLI1 LOC101929538
GH11J128723 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 -36.1 -36101 17.6 ZNF24 JUND MYC ETV6 RELA POU5F1 POLR2A MLLT1 ZNF687 CREM FLI1 SENCR ENSG00000245008 KCNJ1 ETS1 lnc-KCNJ5-2
GH11J128620 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +70.1 70093 10.8 CTCF ETV6 RELA MAX RAD21 TEAD4 SP1 CBFA2T2 MLLT1 ZNF687 FLI1 ETS1 SENCR ETS1-AS1 LOC105369568 ENSG00000245008
GH11J128288 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.5 +398.0 398016 18.3 ZNF24 SP1 CTCF RBPJ MYC ETV6 RELA CEBPB MAX RAD21 ETS1 FLI1 ETS1-AS1 SENCR lnc-ETS1-8 lnc-FLI1-3
GH11J128751 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 -60.1 -60134 8.3 SP1 MYC ETV6 RELA RAD21 MAX CTCF ZNF687 CREM IKZF1 ENSG00000245008 FLI1 SENCR ETS1-AS1 KCNJ1 lnc-KCNJ5-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENCR on UCSC Golden Path with GeneCards custom track

Genomic Locations for SENCR Gene

Genomic Locations for SENCR Gene
chr11:128,691,672-128,696,030
(GRCh38/hg38)
Size:
4,359 bases
Orientation:
Minus strand
chr11:128,561,567-128,565,918
(GRCh37/hg19)
Size:
4,352 bases
Orientation:
Minus strand

Genomic View for SENCR Gene

Genes around SENCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENCR Gene

Proteins for SENCR Gene

No data available for DME Specific Peptides for SENCR Gene

Domains & Families for SENCR Gene

Gene Families for SENCR Gene

genes like me logo Genes that share domains with SENCR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SENCR Gene

Function for SENCR Gene

Phenotypes From GWAS Catalog for SENCR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SENCR Gene

Localization for SENCR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SENCR Gene

Pathways & Interactions for SENCR Gene

PathCards logo

SuperPathways for SENCR Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENCR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SENCR Gene

Drugs & Compounds for SENCR Gene

No Compound Related Data Available

Transcripts for SENCR Gene

mRNA/cDNA for SENCR Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) NONCODE transcripts :
(6) RNACentral transcripts :
(2) ENA transcripts :
(2) LncBook transcripts :
(2) LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for SENCR Gene

No ASD Table

Relevant External Links for SENCR Gene

GeneLoc Exon Structure for
SENCR
ECgene alternative splicing isoforms for
SENCR

Expression for SENCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SENCR Gene

mRNA differential expression in normal tissues according to GTEx for SENCR Gene

This gene is overexpressed in Whole Blood (x7.9) and Spleen (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of SENCR Gene:

SENCR
genes like me logo Genes that share expression patterns with SENCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENCR Gene

Orthologs for SENCR Gene

Evolution for SENCR Gene

ENSEMBL:
Gene Tree for SENCR (if available)
TreeFam:
Gene Tree for SENCR (if available)

No data available for Orthologs for SENCR Gene

Paralogs for SENCR Gene

No data available for Paralogs for SENCR Gene

Variants for SENCR Gene

Sequence variations from dbSNP and Humsavar for SENCR Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000050060 -- 128,693,519(-) C/A/G/T intron_variant
rs1001533802 -- 128,694,043(-) T/C intron_variant
rs1001669509 -- 128,696,002(-) A/G non_coding_transcript_variant
rs1001803809 -- 128,695,660(-) C/T intron_variant
rs1001865939 -- 128,695,164(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SENCR Gene

Variant ID Type Subtype PubMed ID
nsv1070495 CNV deletion 25765185
nsv826128 CNV gain 20364138
nsv952759 CNV duplication 24416366

Additional Variant Information for SENCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SENCR Gene

Disorders for SENCR Gene

Additional Disease Information for SENCR

No disorders were found for SENCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SENCR Gene

Publications for SENCR Gene

  1. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. (PMID: 24578380) Bell RD … Miano JM (Arteriosclerosis, thrombosis, and vascular biology 2014) 2 3 56
  2. SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4. (PMID: 30584103) Lyu Q … Miano JM (Proceedings of the National Academy of Sciences of the United States of America 2019) 3 56
  3. Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. (PMID: 29845247) Sun H … Song M (Molecular medicine reports 2018) 3 56
  4. Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease. (PMID: 29118951) Shahmoradi N … Kheiry MA (Journal of cardiovascular and thoracic research 2017) 3 56
  5. A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells. (PMID: 26898221) Boulberdaa M … Baker AH (Molecular therapy : the journal of the American Society of Gene Therapy 2016) 3 56

Products for SENCR Gene

Sources for SENCR Gene