Aliases for SENCR Gene

Data sources for SENCR Gene:

Subcategory (RNA class) for SENCR Gene

lncRNA

Aliases for SENCR Gene

External Ids for SENCR Gene

Previous HGNC Symbols for SENCR Gene

  • FLI1-AS1

Previous GeneCards Identifiers for SENCR Gene

  • GC11M128564

Summaries for SENCR Gene

GeneCards Summary for SENCR Gene

SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for SENCR Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SENCR Gene

Genomics for SENCR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SENCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J128692 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.9 933 7.4 ZIC2 SIN3A GABPA CTCF ZNF639 MAFF ZNF341 EBF1 KLF9 MAX SENCR FLI1 HSALNG0088109 KCNJ1
GH11J128723 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 -36.1 -36101 17.6 BCL11A POLR2A SIN3A GABPA VEZF1 TRIM22 IRF4 ZNF341 EBF1 MAX FLI1 SENCR LOC101929538 KCNJ1 ETS1 lnc-KCNJ5-2
GH11J128620 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +70.1 70093 10.8 CTCF ZNF395 REST TRIM22 RXRA EBF1 SMC3 RAD21 MAX FOSL1 FLI1 ETS1 SENCR ETS1-AS1 LOC105369568 LOC101929538
GH11J128288 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.5 +398.0 398016 18.3 SP1 BCL11A FEZF1 POLR2A CTCF SIN3A TRIM22 IRF4 MAFF RXRA ETS1 FLI1 ETS1-AS1 SENCR LOC107984408 lnc-FLI1-3 HSALNG0088094 HSALNG0088091-002 lnc-ETS1-8
GH11J128775 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -80.0 -79971 4.8 CTCF TAL1 SMC3 RAD21 NRF1 L3MBTL2 RCOR1 GATA2 EZH2 CEBPB SENCR FLI1 lnc-KCNJ5-2 KCNJ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SENCR on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SENCR Gene

Latest Assembly
chr11:128,691,671-128,696,030
(GRCh38/hg38)
Size:
4,360 bases
Orientation:
Minus strand

Previous Assembly
chr11:128,561,567-128,565,918
(GRCh37/hg19 by Entrez Gene)
Size:
4,352 bases
Orientation:
Minus strand

chr11:128,561,567-128,565,918
(GRCh37/hg19 by Ensembl)
Size:
4,352 bases
Orientation:
Minus strand

Genomic View for SENCR Gene

Genes around SENCR on UCSC Golden Path with GeneCards custom track
SENCR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
SENCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENCR Gene

Proteins for SENCR Gene

Post-translational modifications for SENCR Gene

No Post-translational modifications

No data available for DME Specific Peptides for SENCR Gene

Domains & Families for SENCR Gene

Gene Families for SENCR Gene

genes like me logo Genes that share domains with SENCR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SENCR Gene

Function for SENCR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SENCR Gene

Localization for SENCR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENCR gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SENCR Gene

Pathways & Interactions for SENCR Gene

PathCards logo

SuperPathways for SENCR Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENCR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SENCR Gene

Drugs & Compounds for SENCR Gene

No Compound Related Data Available

Transcripts for SENCR Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SENCR Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000602E27_9606 lncRNA 1298 3

Ensembl: ENST00000526269 (view in UCSC) ,

LNCipedia: SENCR:2,

NONCODE: NONHSAT025072.2,

URS000075E93E_9606 lncRNA 1298 1

RefSeq: NR_038908,

URS00008BA62F_9606 lncRNA 1290 2

LncBook: HSALNT0183247,

LNCipedia: SENCR:1,

URS00009BAA49_9606 lncRNA 1290 2

LncBook: HSALNT0183246,

NONCODE: NONHSAT160892.1,

URS00007F6900_9606 lncRNA 1305 1

ENA: KF806591.1:1..1324:ncRNA,

SENCR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for SENCR Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for SENCR Gene

No ASD Table

Relevant External Links for SENCR Gene

GeneLoc Exon Structure for
SENCR

Expression for SENCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENCR Gene

mRNA differential expression in normal tissues according to GTEx for SENCR Gene

This gene is overexpressed in Whole Blood (x7.9) and Spleen (x6.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SENCR

genes like me logo Genes that share expression patterns with SENCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENCR Gene

Orthologs for SENCR Gene

Evolution for SENCR Gene

ENSEMBL:
Gene Tree for SENCR (if available)
TreeFam:
Gene Tree for SENCR (if available)

No data available for Orthologs for SENCR Gene

Paralogs for SENCR Gene

No data available for Paralogs for SENCR Gene

Variants for SENCR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SENCR Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1425813965 Likely Benign: not provided 128,694,270(-) T/C
NM_002017.5(FLI1):c.12T>C (p.Thr4=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SENCR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SENCR Gene

Variant ID Type Subtype PubMed ID
nsv1070495 CNV deletion 25765185
nsv826128 CNV gain 20364138
nsv952759 CNV duplication 24416366

Additional Variant Information for SENCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENCR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SENCR Gene

Disorders for SENCR Gene

Additional Disease Information for SENCR

No disorders were found for SENCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SENCR Gene

Publications for SENCR Gene

  1. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. (PMID: 24578380) Bell RD … Miano JM (Arteriosclerosis, thrombosis, and vascular biology 2014) 2 3
  2. SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4. (PMID: 30584103) Lyu Q … Miano JM (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
  3. Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. (PMID: 29845247) Sun H … Song M (Molecular medicine reports 2018) 3
  4. Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease. (PMID: 29118951) Shahmoradi N … Kheiry MA (Journal of cardiovascular and thoracic research 2017) 3
  5. A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells. (PMID: 26898221) Boulberdaa M … Baker AH (Molecular therapy : the journal of the American Society of Gene Therapy 2016) 3

Products for SENCR Gene

Sources for SENCR Gene