The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, i... See more...

Aliases for SEMG1 Gene

Aliases for SEMG1 Gene

  • Semenogelin 1 2 3 5
  • Cancer/Testis Antigen 103 2 3 4
  • Semenogelin I 2 3 4
  • Semen Coagulating Protein 2 3
  • Semenogelin-1 3 4
  • SEMG 3 4
  • SGI 3 4
  • DJ172H20.2 3
  • SgI-29 3
  • CT103 3

External Ids for SEMG1 Gene

Previous HGNC Symbols for SEMG1 Gene

  • SEMG

Previous GeneCards Identifiers for SEMG1 Gene

  • GC20P043564
  • GC20P044474
  • GC20P044521
  • GC20P043269
  • GC20P043835
  • GC20P040577

Summaries for SEMG1 Gene

Entrez Gene Summary for SEMG1 Gene

  • The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

GeneCards Summary for SEMG1 Gene

SEMG1 (Semenogelin 1) is a Protein Coding gene. Diseases associated with SEMG1 include Male Infertility and Pelvic Varices. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.

UniProtKB/Swiss-Prot Summary for SEMG1 Gene

  • Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
  • Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Wiki entry for SEMG1 Gene

Additional gene information for SEMG1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEMG1 Gene

Genomics for SEMG1 Gene

GeneHancer (GH) Regulatory Elements for SEMG1 Gene

Promoters and enhancers for SEMG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J045206 Promoter/Enhancer 0.6 EPDnew Ensembl 500.7 -0.1 -99 0.6 EP300 NONHSAG031856.2 SEMG1 SLPI piR-33614-178
GH20J045180 Enhancer 0.5 Ensembl 12.9 -27.3 -27270 5.4 DEK MAFF MAFK CEBPB ZNF335 ATF7 LINC02597 lnc-PI3-1 SLPI SEMG1 SEMG2 WFDC5 PI3
GH20J045184 Enhancer 0.2 Ensembl 12.9 -22.3 -22296 0.2 piR-33614-178 SLPI SEMG1 SEMG2 LINC02597 lnc-PI3-1
GH20J045209 Enhancer 0.7 Ensembl ENCODE 0.7 +3.1 3104 1.4 USF1 NONO RAD51 HDAC2 SALL2 NANOG FOXP1 EP300 ZNF366 EGR1 SLPI GDAP1L1 RIMS4 NONHSAG031856.2 SEMG1 SEMG2
GH20J045185 Enhancer 0.5 Ensembl 0.4 -19.8 -19796 3.2 FOXA1 FOXA2 CTCF SNIP1 RAD21 MEIS2 SLPI SEMG2 WFDC5 piR-33614-178 LINC02597 lnc-PI3-1 SEMG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEMG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEMG1

Top Transcription factor binding sites by QIAGEN in the SEMG1 gene promoter:
  • Cdc5
  • E47
  • HOXA3
  • IRF-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SEMG1 Gene

Genomic Locations for SEMG1 Gene
chr20:45,206,997-45,209,773
(GRCh38/hg38)
Size:
2,777 bases
Orientation:
Plus strand
chr20:43,835,638-43,838,414
(GRCh37/hg19)
Size:
2,777 bases
Orientation:
Plus strand

Genomic View for SEMG1 Gene

Genes around SEMG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG1 Gene

Proteins for SEMG1 Gene

  • Protein details for SEMG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04279-SEMG1_HUMAN
    Recommended name:
    Semenogelin-1
    Protein Accession:
    P04279
    Secondary Accessions:
    • Q53ZV0
    • Q53ZV1
    • Q53ZV2
    • Q6X4I9
    • Q6Y809
    • Q6Y822
    • Q6Y823
    • Q86U64
    • Q96QM3

    Protein attributes for SEMG1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52131 Da
    Quaternary structure:
    • Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.

    Alternative splice isoforms for SEMG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMG1 Gene

Post-translational modifications for SEMG1 Gene

  • Transglutaminase substrate.
  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEMG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMG1 Gene

Domains & Families for SEMG1 Gene

Gene Families for SEMG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SEMG1 Gene

Blocks:
  • Semenogelin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEMG1 Gene

GenScript: Design optimal peptide antigens:
  • SEMG1 protein (A0JLP2_HUMAN)
  • Semenogelin I (Q6Y806_HUMAN)
  • Semenogelin I (Q6Y808_HUMAN)
  • Semenogelin I (SEMG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04279

UniProtKB/Swiss-Prot:

SEMG1_HUMAN :
  • Belongs to the semenogelin family.
Family:
  • Belongs to the semenogelin family.
genes like me logo Genes that share domains with SEMG1: view

Function for SEMG1 Gene

Molecular function for SEMG1 Gene

UniProtKB/Swiss-Prot Function:
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
UniProtKB/Swiss-Prot Function:
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.
GENATLAS Biochemistry:
major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2

Phenotypes From GWAS Catalog for SEMG1 Gene

Gene Ontology (GO) - Molecular Function for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8665956
GO:0008270 zinc ion binding IMP 15563730
genes like me logo Genes that share ontologies with SEMG1: view

Phenotypes for SEMG1 Gene

genes like me logo Genes that share phenotypes with SEMG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SEMG1 Gene

Localization for SEMG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMG1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 1517240
GO:0005634 nucleus HDA 21630459
GO:0032991 protein-containing complex IDA 17567961
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SEMG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMG1 Gene

Pathways & Interactions for SEMG1 Gene

genes like me logo Genes that share pathways with SEMG1: view

Pathways by source for SEMG1 Gene

Gene Ontology (GO) - Biological Process for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007320 insemination TAS 2912989
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 18714013
GO:0031640 killing of cells of other organism IDA 18314226
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SEMG1: view

No data available for SIGNOR curated interactions for SEMG1 Gene

Drugs & Compounds for SEMG1 Gene

(4) Drugs for SEMG1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2822
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0
genes like me logo Genes that share compounds with SEMG1: view

Transcripts for SEMG1 Gene

mRNA/cDNA for SEMG1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMG1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG1 Gene

No ASD Table

Relevant External Links for SEMG1 Gene

GeneLoc Exon Structure for
SEMG1

Expression for SEMG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEMG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMG1 Gene

This gene is overexpressed in Prostate (x38.7) and Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for SEMG1 Gene

This gene is overexpressed in Prostate (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEMG1 Gene



Protein tissue co-expression partners for SEMG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEMG1

SOURCE GeneReport for Unigene cluster for SEMG1 Gene:

Hs.1968

mRNA Expression by UniProt/SwissProt for SEMG1 Gene:

P04279-SEMG1_HUMAN
Tissue specificity: Seminal vesicle.

Evidence on tissue expression from TISSUES for SEMG1 Gene

  • Blood(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SEMG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMG1 Gene

Orthologs for SEMG1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SEMG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMG2 31
  • 59 (a)
OneToOne
Species where no ortholog for SEMG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG1 Gene

ENSEMBL:
Gene Tree for SEMG1 (if available)
TreeFam:
Gene Tree for SEMG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEMG1: view image

Paralogs for SEMG1 Gene

Paralogs for SEMG1 Gene

(1) SIMAP similar genes for SEMG1 Gene using alignment to 4 proteins:

  • SEMG1_HUMAN
  • A0JLP2_HUMAN
  • Q6Y806_HUMAN
  • Q6Y808_HUMAN
genes like me logo Genes that share paralogs with SEMG1: view

Variants for SEMG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEMG1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs11559137 - p.Glu58Gly
rs2233884 - p.His108Arg
rs2233887 - p.Arg372Leu
rs2301366 - p.Ser79Thr

Additional dbSNP identifiers (rs#s) for SEMG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SEMG1 Gene

Variant ID Type Subtype PubMed ID
esv2663630 CNV deletion 23128226
esv3557116 CNV deletion 23714750
nsv1056102 CNV loss 25217958
nsv482068 CNV gain 20164927

Variation tolerance for SEMG1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMG1 Gene

Human Gene Mutation Database (HGMD)
SEMG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMG1 Gene

Disorders for SEMG1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SEMG1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SEMG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SEMG1

genes like me logo Genes that share disorders with SEMG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMG1 Gene

Publications for SEMG1 Gene

  1. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. (PMID: 19889947) Mitra A … O'Rand MG (Biology of reproduction 2010) 3 4 23 54
  2. Characterization of an eppin protein complex from human semen and spermatozoa. (PMID: 17567961) Wang Z … O'Rand MG (Biology of reproduction 2007) 3 4 23 54
  3. Association of eppin with semenogelin on human spermatozoa. (PMID: 15590901) Wang Z … Richardson RT (Biology of reproduction 2005) 3 4 23 54
  4. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PMID: 15563730) Jonsson M … Malm J (The Biochemical journal 2005) 2 3 23 54
  5. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PMID: 14629036) Jensen-Seaman MI … Li WH (Journal of molecular evolution 2003) 3 4 23 54

Products for SEMG1 Gene

Sources for SEMG1 Gene