Aliases for SEMA5A Gene
External Ids for SEMA5A Gene
Previous HGNC Symbols for SEMA5A Gene
Previous GeneCards Identifiers for SEMA5A Gene
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for SEMA5A Gene
SEMA5A (Semaphorin 5A) is a Protein Coding gene. Diseases associated with SEMA5A include Cri-Du-Chat Syndrome and Autism. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include semaphorin receptor binding. An important paralog of this gene is SEMA5B.
UniProtKB/Swiss-Prot Summary for SEMA5A Gene
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.