Aliases for SEMA4G Gene
External Ids for SEMA4G Gene
Previous GeneCards Identifiers for SEMA4G Gene
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for SEMA4G Gene
SEMA4G (Semaphorin 4G) is a Protein Coding gene. Diseases associated with SEMA4G include Diffuse Glomerulonephritis and Alzheimer Disease. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is SEMA4C.
UniProtKB/Swiss-Prot Summary for SEMA4G Gene
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).