Aliases for SEMA4D Gene

Aliases for SEMA4D Gene

  • Semaphorin 4D 2 3 5
  • CD100 2 3 4
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4D 2 3
  • Semaphorin-4D 3 4
  • C9orf164 3 4
  • Coll-4 2 3
  • SEMAJ 3 4
  • BB18 3 4
  • GR3 3 4
  • A8 3 4
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, 4D 3
  • Chromosome 9 Open Reading Frame 164 2
  • CD100 Antigen 4
  • M-Sema G 2
  • M-Sema-G 3
  • FLJ39737 2
  • SEMA4D 5
  • COLL4 3

External Ids for SEMA4D Gene

Previous HGNC Symbols for SEMA4D Gene

  • SEMAJ
  • C9orf164

Previous GeneCards Identifiers for SEMA4D Gene

  • GC09U990094
  • GC09M083868
  • GC09M085576
  • GC09M9O0142
  • GC09M089221
  • GC09M091181
  • GC09M091975
  • GC09M061809

Summaries for SEMA4D Gene

GeneCards Summary for SEMA4D Gene

SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Autoimmune Vasculitis and Osteonecrosis Of The Jaw. Among its related pathways are Guidance Cues and Growth Cone Motility and Axon guidance. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.

UniProtKB/Swiss-Prot Summary for SEMA4D Gene

  • Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).

Gene Wiki entry for SEMA4D Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEMA4D Gene

Genomics for SEMA4D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEMA4D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J089495 Promoter/Enhancer 1.8 EPDnew ENCODE CraniofacialAtlas dbSUPER 613.9 -0.1 -93 4.5 PRDM10 KDM1A ZNF692 PRDM1 ZIC2 POLR2A MTA1 PATZ1 TRIM22 ZNF341 SEMA4D SECISBP2 piR-44878-061 GADD45G lnc-SEMA4D-5 MN298114-298
GH09J089433 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 621.1 +62.1 62083 4.6 CEBPG TEAD4 ZHX2 TCF12 CEBPA CEBPB JUND RUNX3 CTBP1 FOS SEMA4D lnc-SHC3-7 SECISBP2 lnc-SHC3-6 MN298114-298
GH09J089405 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.3 +89.6 89612 6.7 KDM1A POLR2A STAT3 ZNF143 RELA RAD21 IKZF2 RCOR1 TRIM22 EED SEMA4D SECISBP2 lnc-SHC3-7 lnc-SHC3-6 MN298114-298
GH09J089417 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 24 +74.2 74180 12.9 SP1 CTCF POLR2A ZNF143 RELA RAD21 TCF12 IKZF2 TRIM22 YY1 SEMA4D CKS2 SECISBP2 S1PR3 C9orf47 lnc-SHC3-7 lnc-SHC3-6 MN298114-298
GH09J089439 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 21.7 +55.1 55102 6.7 CREB1 ZBTB33 ZIC2 POLR2A TCF12 EED RUNX3 BCLAF1 ZFHX2 IKZF1 SEMA4D PA2G4P6 lnc-SHC3-7 SECISBP2 MN298114-298
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEMA4D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEMA4D

Top Transcription factor binding sites by QIAGEN in the SEMA4D gene promoter:
  • AP-1
  • CP2
  • Elk-1
  • Evi-1
  • FOXL1
  • MyoD
  • p53
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for SEMA4D Gene

Genomic Locations for SEMA4D Gene
chr9:89,360,787-89,498,130
(GRCh38/hg38)
Size:
137,344 bases
Orientation:
Minus strand
chr9:91,975,702-92,113,045
(GRCh37/hg19)
Size:
137,344 bases
Orientation:
Minus strand

Genomic View for SEMA4D Gene

Genes around SEMA4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4D Gene

Proteins for SEMA4D Gene

  • Protein details for SEMA4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92854-SEM4D_HUMAN
    Recommended name:
    Semaphorin-4D
    Protein Accession:
    Q92854
    Secondary Accessions:
    • B2RPM6
    • Q7Z5S4
    • Q8N8B0

    Protein attributes for SEMA4D Gene

    Size:
    862 amino acids
    Molecular mass:
    96150 Da
    Quaternary structure:
    • Homodimer (PubMed:20877282). Interacts with PLXNB2 (By similarity). Interacts with PLXNB1 (PubMed:10520995).
    SequenceCaution:
    • Sequence=AAI37516.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI37519.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAC04938.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEMA4D Gene

    Alternative splice isoforms for SEMA4D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA4D Gene

Post-translational modifications for SEMA4D Gene

  • Glycosylation at Asn49, Asn77, Asn139, Asn191, Asn329, Asn379, Asn419, Asn613, Asn632, Thr657, Thr663, Ser666, Thr670, Thr716, and Ser722
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SEM4D_HUMAN (1734)

Antibody Products

  • Boster Bio Antibodies for SEMA4D

No data available for DME Specific Peptides for SEMA4D Gene

Domains & Families for SEMA4D Gene

Gene Families for SEMA4D Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEMA4D Gene

Suggested Antigen Peptide Sequences for SEMA4D Gene

GenScript: Design optimal peptide antigens:
  • GR3 (SEM4D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92854

UniProtKB/Swiss-Prot:

SEM4D_HUMAN :
  • Belongs to the semaphorin family.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4D: view

Function for SEMA4D Gene

Molecular function for SEMA4D Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
GENATLAS Biochemistry:
semaphorin 4D,mostly expressed in lymphocytes and the nervous system,inducing B cell to aggregate and improving their viability in vitro,repellent of the nerve growth cone guidance,ligand for plexin B1 (PLXN4)

Phenotypes From GWAS Catalog for SEMA4D Gene

Gene Ontology (GO) - Molecular Function for SEMA4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 20877282
GO:0005102 signaling receptor binding IDA 11254688
GO:0005515 protein binding IPI 20877282
GO:0030215 semaphorin receptor binding ISS --
GO:0038023 signaling receptor activity IDA 15613544
genes like me logo Genes that share ontologies with SEMA4D: view
genes like me logo Genes that share phenotypes with SEMA4D: view

Animal Models for SEMA4D Gene

MGI Knock Outs for SEMA4D:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4D

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMA4D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA4D Gene

Localization for SEMA4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4D Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA4D gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEMA4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA,ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IDA 8876214
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4D: view

Pathways & Interactions for SEMA4D Gene

genes like me logo Genes that share pathways with SEMA4D: view

Pathways by source for SEMA4D Gene

1 GeneGo (Thomson Reuters) pathway for SEMA4D Gene
  • Neurophysiological process Receptor-mediated axon growth repulsion
2 Qiagen pathways for SEMA4D Gene
  • Guidance Cues and Growth Cone Motility
  • Semaphorin Signaling

SIGNOR curated interactions for SEMA4D Gene

Activates:

Gene Ontology (GO) - Biological Process for SEMA4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 22019888
GO:0001755 neural crest cell migration IBA 21873635
GO:0001934 positive regulation of protein phosphorylation IDA 16055703
GO:0006955 immune response TAS 8876214
GO:0007155 cell adhesion TAS 8876214
genes like me logo Genes that share ontologies with SEMA4D: view

Drugs & Compounds for SEMA4D Gene

(6) Drugs for SEMA4D Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 7499
Antibodies, Monoclonal Pharma 3764
Immunoglobulins Pharma 7499
VX15/2503 VACCINE Pharma 0

(1) Additional Compounds for SEMA4D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SEMA4D: view

Transcripts for SEMA4D Gene

mRNA/cDNA for SEMA4D Gene

12 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMA4D

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6:
SP7:
SP8:

ExUns: 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SEMA4D Gene

GeneLoc Exon Structure for
SEMA4D

Expression for SEMA4D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEMA4D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4D Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.0) and Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for SEMA4D Gene

This gene is overexpressed in Lymph node (22.1), CD8 Tcells (11.8), Frontal cortex (10.2), and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEMA4D Gene



Protein tissue co-expression partners for SEMA4D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEMA4D

SOURCE GeneReport for Unigene cluster for SEMA4D Gene:

Hs.494406

mRNA Expression by UniProt/SwissProt for SEMA4D Gene:

Q92854-SEM4D_HUMAN
Tissue specificity: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.

Evidence on tissue expression from TISSUES for SEMA4D Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Intestine(4.5)
  • Eye(4.5)
  • Lymph node(3)
  • Spleen(2.9)
  • Muscle(2.8)
  • Skin(2.8)
  • Heart(2.8)
  • Kidney(2.7)
  • Bone marrow(2.6)
  • Lung(2.3)
  • Adrenal gland(2.1)
  • Bone(2)
genes like me logo Genes that share expression patterns with SEMA4D: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA4D Gene

Orthologs for SEMA4D Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA4D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SEMA4D 30 31
  • 99.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sema4d 30 17 31
  • 82.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sema4d 30
  • 82.21 (n)
Dog
(Canis familiaris)
Mammalia SEMA4D 30 31
  • 82.05 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SEMA4D 31
  • 75 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SEMA4D 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4D 31
  • 36 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SEMA4D 30 31
  • 68.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SEMA4D 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.20164 30
Zebrafish
(Danio rerio)
Actinopterygii sema4d 30
  • 57.33 (n)
SEMA4D 31
  • 48 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4383 32
  • 29 (a)
Sema-2a 32
  • 29 (a)
Species where no ortholog for SEMA4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SEMA4D Gene

ENSEMBL:
Gene Tree for SEMA4D (if available)
TreeFam:
Gene Tree for SEMA4D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEMA4D: view image

Paralogs for SEMA4D Gene

(19) SIMAP similar genes for SEMA4D Gene using alignment to 6 proteins:

  • SEM4D_HUMAN
  • C9JD54_HUMAN
  • C9JFP1_HUMAN
  • C9JYS7_HUMAN
  • E9PFD9_HUMAN
  • F5H044_HUMAN
genes like me logo Genes that share paralogs with SEMA4D: view

Variants for SEMA4D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEMA4D Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
710800 Likely Benign: not provided 89,378,917(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
741057 Benign: not provided 89,388,774(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
776430 Likely Benign: not provided 89,388,738(-) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
792129 Benign: not provided 89,387,377(-) G/A INTRON_VARIANT
rs534671276 Uncertain Significance: Anti-SEMA4D Monoclonal Antibody VX15/2503 89,388,673(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for SEMA4D Gene

Structural Variations from Database of Genomic Variants (DGV) for SEMA4D Gene

Variant ID Type Subtype PubMed ID
esv2294805 CNV deletion 18987734
esv2629900 CNV insertion 19546169
esv2662702 CNV deletion 23128226
esv2668286 CNV deletion 23128226
esv2738727 CNV deletion 23290073
esv2738728 CNV deletion 23290073
esv2738730 CNV deletion 23290073
esv2738731 CNV deletion 23290073
esv2738732 CNV deletion 23290073
esv2738733 CNV deletion 23290073
esv2738734 CNV deletion 23290073
esv2738735 CNV deletion 23290073
esv2738736 CNV deletion 23290073
esv29434 CNV gain+loss 19812545
esv3395094 CNV duplication 20981092
esv3490 CNV loss 18987735
esv3621014 CNV gain 21293372
esv3621027 CNV loss 21293372
esv7634 CNV gain 19470904
nsv1041327 CNV gain 25217958
nsv1142706 CNV deletion 24896259
nsv1147032 CNV deletion 26484159
nsv1154135 CNV duplication 26484159
nsv415790 CNV deletion 16902084
nsv510200 OTHER sequence alteration 20534489
nsv517495 CNV loss 19592680
nsv968724 CNV duplication 23825009

Variation tolerance for SEMA4D Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.89; 91.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMA4D Gene

Human Gene Mutation Database (HGMD)
SEMA4D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMA4D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4D Gene

Disorders for SEMA4D Gene

MalaCards: The human disease database

(3) MalaCards diseases for SEMA4D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autoimmune vasculitis
osteonecrosis of the jaw
kallmann syndrome
  • hypogonadotropic hypogonadism and anosmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEMA4D

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SEMA4D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMA4D Gene

Publications for SEMA4D Gene

  1. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. (PMID: 8876214) Hall KT … Freeman GJ (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23
  2. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. (PMID: 16055703) Basile JR … Gutkind JS (Molecular and cellular biology 2005) 3 4 23
  3. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. (PMID: 10520995) Tamagnone L … Comoglio PM (Cell 1999) 3 4 23
  4. Structural basis of semaphorin-plexin signalling. (PMID: 20877282) Janssen BJ … Jones EY (Nature 2010) 3 4
  5. Candidate gene analysis of semaphorins in patients with Alzheimer's disease. (PMID: 19957197) Villa C … Galimberti D (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2010) 3 41

Products for SEMA4D Gene

Sources for SEMA4D Gene