Aliases for SEMA4D Gene
External Ids for SEMA4D Gene
Previous HGNC Symbols for SEMA4D Gene
Previous GeneCards Identifiers for SEMA4D Gene
GeneCards Summary for SEMA4D Gene
SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Autoimmune Vasculitis and Osteonecrosis Of The Jaw. Among its related pathways are Guidance Cues and Growth Cone Motility and Axon guidance. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.
UniProtKB/Swiss-Prot Summary for SEMA4D Gene
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).