Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Semaphorin 3G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Semaphorin-3G 3
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

Entrez Gene Summary for SEMA3G Gene

  • The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]

GeneCards Summary for SEMA3G Gene

SEMA3G (Semaphorin 3G) is a Protein Coding gene. Diseases associated with SEMA3G include Sialolithiasis. Among its related pathways are Axon guidance. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3E.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Additional gene information for SEMA3G Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

GeneHancer (GH) Regulatory Elements for SEMA3G Gene

Promoters and enhancers for SEMA3G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052443 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.5 484 1.6 ELF3 ZSCAN4 ZNF133 ARID4B RAD21 ZNF48 RARA ZNF335 GLIS2 ZNF366 LOC105377091 SEMA3G NISCH RAD54L2 PPM1M PBRM1 TEX264
GH03I052444 Enhancer 0.3 Ensembl 550.8 +1.7 1684 0.4 ZFHX2 LOC105377091 SEMA3G
GH03I052274 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +162.2 162230 17.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 GLYCTK WDR82 LOC101929054 PPM1M TWF2 ITIH4 PBRM1 ENSG00000173366 TLR9 SEMA3G
GH03I052408 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.4 +34.5 34545 3.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 PHF7 BAP1 SEMA3G NISCH TNNC1 GLYCTK-AS1 MIR135A1 GLYCTK WDR82 RNU6-856P
GH03I052466 Enhancer 1 VISTA FANTOM5 dbSUPER 12.2 -23.1 -23096 3 ZNF121 ATF4 POLR2A MNT PRDM1 NR2F2 NT5DC2 SEMA3G STAB1 SMIM4 RNU6-856P RNU6ATAC16P PBRM1 GNL3 ENSG00000222345 ENSG00000252787
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEMA3G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEMA3G gene promoter:

Genomic Locations for SEMA3G Gene

Genomic Locations for SEMA3G Gene
12,033 bases
Minus strand

Genomic View for SEMA3G Gene

Genes around SEMA3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Post-translational modifications for SEMA3G Gene

  • Glycosylation at posLast=4444 and isoforms=127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Gene Families for SEMA3G Gene

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the semaphorin family.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Phenotypes From GWAS Catalog for SEMA3G Gene

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
GO:0038191 neuropilin binding IBA --
genes like me logo Genes that share ontologies with SEMA3G: view
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Models for SEMA3G Gene

MGI Knock Outs for SEMA3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA,HDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMA3G Gene

Pathways & Interactions for SEMA3G Gene

SuperPathways for SEMA3G Gene

SuperPathway Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030517 negative regulation of axon extension ISS,IEA --
GO:0050919 negative chemotaxis IBA --
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for SIGNOR curated interactions for SEMA3G Gene

Drugs & Compounds for SEMA3G Gene

No Compound Related Data Available

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene

Protein tissue co-expression partners for SEMA3G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA3G Gene:


SOURCE GeneReport for Unigene cluster for SEMA3G Gene:


Evidence on tissue expression from TISSUES for SEMA3G Gene

  • Spleen(4.2)
  • Heart(2.4)
  • Muscle(2.3)
  • Blood(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SEMA3G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEMA3G 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia SEMA3G 33 34
  • 87.44 (n)
(Bos Taurus)
Mammalia SEMA3G 33 34
  • 86.74 (n)
(Rattus norvegicus)
Mammalia Sema3g 33
  • 85.2 (n)
(Mus musculus)
Mammalia Sema3g 33 16 34
  • 84.74 (n)
(Monodelphis domestica)
Mammalia SEMA3G 34
  • 78 (a)
(Gallus gallus)
Aves SEMA3G 33 34
  • 70.5 (n)
(Anolis carolinensis)
Reptilia SEMA3G 34
  • 64 (a)
(Danio rerio)
Actinopterygii sema3bl 33 34
  • 62.63 (n)
Species where no ortholog for SEMA3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

Gene Tree for SEMA3G (if available)
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000261205 -- 52,434,626(-) C/A/T 3_prime_UTR_variant
rs1000329877 -- 52,446,654(-) T/C upstream_transcript_variant
rs1000421456 -- 52,435,404(-) G/A 3_prime_UTR_variant
rs1000628660 -- 52,440,655(-) G/C intron_variant
rs1001184700 -- 52,446,579(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
esv2725273 CNV deletion 23290073
esv2725275 CNV deletion 23290073
esv2725276 CNV deletion 23290073
nsv1130796 CNV deletion 24896259
nsv1148206 CNV deletion 26484159
nsv236985 CNV deletion 16902084
nsv590303 CNV loss 21841781
nsv834696 CNV loss 17160897
nsv834697 CNV loss 17160897
nsv954860 CNV deletion 24416366

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMA3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEMA3G Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • salivary gland stone
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEMA3G

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SEMA3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 58
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58

Products for SEMA3G Gene

Sources for SEMA3G Gene

Loading form....