The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016] See more...

Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Semaphorin 3G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Semaphorin-3G 3 4
  • Sem2 2 3
  • FLJ00014 2
  • SEMA3G 5

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444
  • GC03M052467

Summaries for SEMA3G Gene

Entrez Gene Summary for SEMA3G Gene

  • The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]

GeneCards Summary for SEMA3G Gene

SEMA3G (Semaphorin 3G) is a Protein Coding gene. Diseases associated with SEMA3G include Kallmann Syndrome. Among its related pathways are Axon guidance. An important paralog of this gene is SEMA3E.

UniProtKB/Swiss-Prot Summary for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Additional gene information for SEMA3G Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEMA3G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEMA3G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEMA3G

Top Transcription factor binding sites by QIAGEN in the SEMA3G gene promoter:
  • ATF
  • c-Myc
  • COUP
  • COUP-TF
  • Max1
  • Olf-1
  • Pax-4a
  • Sp1

Genomic Locations for SEMA3G Gene

Genomic Locations for SEMA3G Gene
chr3:52,433,035-52,445,113
(GRCh38/hg38)
Size:
12,079 bases
Orientation:
Minus strand
chr3:52,467,069-52,479,101
(GRCh37/hg19)
Size:
12,033 bases
Orientation:
Minus strand

Genomic View for SEMA3G Gene

Genes around SEMA3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS98-SEM3G_HUMAN
    Recommended name:
    Semaphorin-3G
    Protein Accession:
    Q9NS98
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    Size:
    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn44 and Asn127
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SEM3G_HUMAN (1732)

Other Protein References for SEMA3G Gene

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Gene Families for SEMA3G Gene

Protein Domains for SEMA3G Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
  • Semaphorin/CD100 antigen
ProtoNet:

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:
  • Semaphorin sem2 (SEM3G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS98

UniProtKB/Swiss-Prot:

SEM3G_HUMAN :
  • Belongs to the semaphorin family.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Phenotypes From GWAS Catalog for SEMA3G Gene

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA,ISS --
GO:0005515 protein binding IEA --
GO:0030215 semaphorin receptor binding IEA,IBA 21873635
GO:0045499 chemorepellent activity IBA 21873635
genes like me logo Genes that share ontologies with SEMA3G: view
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Models for SEMA3G Gene

MGI Knock Outs for SEMA3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3G

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMA3G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMA3G Gene

Pathways & Interactions for SEMA3G Gene

PathCards logo

SuperPathways for SEMA3G Gene

SuperPathway Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA 21873635
GO:0007411 axon guidance IBA 21873635
GO:0030335 positive regulation of cell migration IBA 21873635
GO:0030517 negative regulation of axon extension IEA,ISS --
GO:0048843 negative regulation of axon extension involved in axon guidance IBA 21873635
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for SIGNOR curated interactions for SEMA3G Gene

Drugs & Compounds for SEMA3G Gene

No Compound Related Data Available

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEMA3G

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
SEMA3G

Expression for SEMA3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEMA3G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEMA3G Gene



Protein tissue co-expression partners for SEMA3G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEMA3G

SOURCE GeneReport for Unigene cluster for SEMA3G Gene:

Hs.59729

Evidence on tissue expression from TISSUES for SEMA3G Gene

  • Spleen(4.5)
  • Nervous system(3.3)
  • Heart(2.8)
  • Muscle(2.6)
  • Eye(2.6)
  • Kidney(2.6)
  • Blood(2.4)
  • Lung(2.3)
  • Liver(2.3)
  • Skin(2.3)
  • Lymph node(2.1)
  • Adrenal gland(2.1)
  • Thyroid gland(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SEMA3G: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SEMA3G 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SEMA3G 30 31
  • 87.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SEMA3G 30 31
  • 86.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sema3g 30
  • 85.2 (n)
Mouse
(Mus musculus)
Mammalia Sema3g 30 17 31
  • 84.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SEMA3G 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SEMA3G 30 31
  • 70.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SEMA3G 31
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii sema3bl 30 31
  • 62.63 (n)
OneToOne
Species where no ortholog for SEMA3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

ENSEMBL:
Gene Tree for SEMA3G (if available)
TreeFam:
Gene Tree for SEMA3G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEMA3G: view image

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

  • SEM3G_HUMAN
  • C9JXB2_HUMAN
  • H7C5M7_HUMAN
genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEMA3G Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
767909 Benign: not provided 52,441,580(-) A/G SYNONYMOUS_VARIANT
776467 Benign: not provided 52,440,464(-) A/G SYNONYMOUS_VARIANT
rs2276833 - p.Ile232Thr
rs34540591 - p.Val332Ile
rs35811072 - p.Ser180Asn

Additional dbSNP identifiers (rs#s) for SEMA3G Gene

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
esv2725273 CNV deletion 23290073
esv2725275 CNV deletion 23290073
esv2725276 CNV deletion 23290073
nsv1130796 CNV deletion 24896259
nsv1148206 CNV deletion 26484159
nsv236985 CNV deletion 16902084
nsv590303 CNV loss 21841781
nsv834696 CNV loss 17160897
nsv834697 CNV loss 17160897
nsv954860 CNV deletion 24416366

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMA3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMA3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEMA3G Gene - From: DISEASES

Disorder Aliases PubMed IDs
kallmann syndrome
  • hypogonadotropic hypogonadism and anosmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEMA3G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SEMA3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SEMA3G Gene

Sources for SEMA3G Gene