Aliases for SEMA3D Gene
External Ids for SEMA3D Gene
Previous GeneCards Identifiers for SEMA3D Gene
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
GeneCards Summary for SEMA3D Gene
SEMA3D (Semaphorin 3D) is a Protein Coding gene. Diseases associated with SEMA3D include Meniere Disease and Hirschsprung Disease 1. Among its related pathways are Axon guidance. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3A.
UniProtKB/Swiss-Prot for SEMA3D Gene
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity).