Aliases for SEMA3C Gene
External Ids for SEMA3C Gene
Previous HGNC Symbols for SEMA3C Gene
Previous GeneCards Identifiers for SEMA3C Gene
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
GeneCards Summary for SEMA3C Gene
SEMA3C (Semaphorin 3C) is a Protein Coding gene. Diseases associated with SEMA3C include Posterior Cortical Atrophy and Hirschsprung Disease 1. Among its related pathways are Axon guidance. Gene Ontology (GO) annotations related to this gene include receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA3F.
UniProtKB/Swiss-Prot for SEMA3C Gene
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).