This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This prot... See more...

Aliases for SELPLG Gene

Aliases for SELPLG Gene

  • Selectin P Ligand 2 3 4 5
  • PSGL-1 2 3 4
  • P-Selectin Glycoprotein Ligand 1 3 4
  • CD162 2 3
  • Cutaneous Lymphocyte-Associated Associated Antigen 3
  • CD162 Antigen 4
  • SELPLG 5
  • PSGL1 3
  • CLA 3

External Ids for SELPLG Gene

Previous GeneCards Identifiers for SELPLG Gene

  • GC12M108122
  • GC12M108896
  • GC12M108948
  • GC12M107518
  • GC12M109015
  • GC12M106080

Summaries for SELPLG Gene

Entrez Gene Summary for SELPLG Gene

  • This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

GeneCards Summary for SELPLG Gene

SELPLG (Selectin P Ligand) is a Protein Coding gene. Diseases associated with SELPLG include Human Granulocytic Anaplasmosis and Ehrlichiosis. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot Summary for SELPLG Gene

  • A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
  • (Microbial infection) Acts as a receptor for enterovirus 71.

Gene Wiki entry for SELPLG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELPLG Gene

Genomics for SELPLG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SELPLG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108626 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 611.7 +0.5 513 13.4 RNF2 SP1 PRDM10 ZNF629 RFX1 LEF1 IKZF1 KDM1A ZNF692 POLR2A SELPLG piR-48759-066 SART3 PWP1 PRDM4 UBE3B CORO1C FICD LOC101929162 TMEM119
GH12J108654 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.4 -20.4 -20420 0.1 piR-32677-113 piR-45504-118 piR-50308-128 SELPLG lnc-SELPLG-1 CORO1C
GH12J108820 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.2 -196.9 -196855 21.6 RNF2 SP1 GATAD2A PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 RCOR2 SART3 SSH1 CORO1C SELPLG ALKBH2 UBE3B WSCD2 ACACB CMKLR1 FICD
GH12J108726 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -97.1 -97146 9.3 SP1 CREB1 GATAD2A CTCF HNRNPL ATF7 TEAD4 PRDM10 REST ZNF629 CORO1C RNU7-169P SSH1 LOC101929162 SELPLG PRDM4 ENSG00000257221 ACACB FOXN4 LOC105369969
GH12J108663 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -32.1 -32058 5.8 SP1 GATAD2A CTCF ATF7 ZNF629 TFE3 IKZF1 NFKBIZ ZNF692 RCOR2 CORO1C SELPLG SSH1 ISCU SART3 ENSG00000257221 MVK ACACB RF00066-053 RNU7-169P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELPLG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELPLG

Top Transcription factor binding sites by QIAGEN in the SELPLG gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • NF-kappaB1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for SELPLG Gene

Genomic Locations for SELPLG Gene
chr12:108,621,895-108,633,959
(GRCh38/hg38)
Size:
12,065 bases
Orientation:
Minus strand
chr12:109,015,671-109,027,735
(GRCh37/hg19)
Size:
12,065 bases
Orientation:
Minus strand

Genomic View for SELPLG Gene

Genes around SELPLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELPLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELPLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELPLG Gene

Proteins for SELPLG Gene

  • Protein details for SELPLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14242-SELPL_HUMAN
    Recommended name:
    P-selectin glycoprotein ligand 1
    Protein Accession:
    Q14242
    Secondary Accessions:
    • A8K2Y0
    • B4DQC3
    • B7Z5C7
    • J3KMX6
    • Q12775
    • Q6GTW7
    • Q8N7J7

    Protein attributes for SELPLG Gene

    Size:
    412 amino acids
    Molecular mass:
    43201 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparently not tyrosine sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK; mediates the activation of SYK by SELPLG.
    • (Microbial infection) Interacts with enterovirus 71 capsid proteins.
    • (Microbial infection) Interacts with Staphylococcus aureus proteins SSL5 and SSL11; these interactions prevent SELPLG-mediated neutrophil rolling.

    Three dimensional structures from OCA and Proteopedia for SELPLG Gene

    Alternative splice isoforms for SELPLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELPLG Gene

Post-translational modifications for SELPLG Gene

  • Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
  • Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
  • Glycosylation at Thr57, Asn65, Asn111, Ser287, Ser289, Ser290, Thr292, and Asn302
  • Ubiquitination at Lys386
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SELPL_HUMAN (520)

Other Protein References for SELPLG Gene

Antibody Products

No data available for DME Specific Peptides for SELPLG Gene

Domains & Families for SELPLG Gene

Gene Families for SELPLG Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for SELPLG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELPLG Gene

GenScript: Design optimal peptide antigens:
  • Selectin P ligand (SELPL_HUMAN)
genes like me logo Genes that share domains with SELPLG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SELPLG Gene

Function for SELPLG Gene

Molecular function for SELPLG Gene

UniProtKB/Swiss-Prot Function:
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for enterovirus 71.
GENATLAS Biochemistry:
P-selectin glycoprotein ligand with homology to CD43 and GP1BA

Phenotypes From GWAS Catalog for SELPLG Gene

Gene Ontology (GO) - Molecular Function for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 signaling receptor binding NAS 7505206
GO:0005515 protein binding IPI 11081633
genes like me logo Genes that share ontologies with SELPLG: view
genes like me logo Genes that share phenotypes with SELPLG: view

Animal Models for SELPLG Gene

MGI Knock Outs for SELPLG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELPLG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELPLG Gene

Localization for SELPLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELPLG Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELPLG gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505206
GO:0016020 membrane IEA,TAS 7505206
GO:0016021 integral component of membrane IEA,TAS 7541799
genes like me logo Genes that share ontologies with SELPLG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELPLG Gene

Pathways & Interactions for SELPLG Gene

genes like me logo Genes that share pathways with SELPLG: view

Pathways by source for SELPLG Gene

1 BioSystems pathway for SELPLG Gene
2 Reactome pathways for SELPLG Gene

SIGNOR curated interactions for SELPLG Gene

Activates:

Gene Ontology (GO) - Biological Process for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7505206
GO:0016032 viral process IEA --
GO:0030097 hemopoiesis IBA 21873635
GO:0046718 viral entry into host cell IEA --
GO:0050900 leukocyte migration IDA,TAS --
genes like me logo Genes that share ontologies with SELPLG: view

Drugs & Compounds for SELPLG Gene

(17) Drugs for SELPLG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556

(17) Additional Compounds for SELPLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELPLG: view

Transcripts for SELPLG Gene

mRNA/cDNA for SELPLG Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELPLG

Alternative Splicing Database (ASD) splice patterns (SP) for SELPLG Gene

No ASD Table

Relevant External Links for SELPLG Gene

GeneLoc Exon Structure for
SELPLG

Expression for SELPLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SELPLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELPLG Gene

This gene is overexpressed in Whole Blood (x40.2).

Protein differential expression in normal tissues from HIPED for SELPLG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Monocytes (14.8), Lymph node (10.4), Cerebral cortex (9.2), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SELPLG Gene



Protein tissue co-expression partners for SELPLG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELPLG

SOURCE GeneReport for Unigene cluster for SELPLG Gene:

Hs.591014

mRNA Expression by UniProt/SwissProt for SELPLG Gene:

Q14242-SELPL_HUMAN
Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes.

Evidence on tissue expression from TISSUES for SELPLG Gene

  • Nervous system(4.9)
  • Blood(4.9)
  • Spleen(3.8)
  • Lymph node(3.1)
  • Intestine(3)
  • Heart(2.9)
  • Bone marrow(2.8)
  • Lung(2.8)
  • Liver(2.4)
  • Muscle(2.3)
  • Skin(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SELPLG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SELPLG Gene

Orthologs for SELPLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELPLG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SELPLG 30 31
  • 99.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SELPLG 30 31
  • 67.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Selplg 30 17 31
  • 67.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SELPLG 30 31
  • 64.15 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Selplg 30
  • 63.45 (n)
Lizard
(Anolis carolinensis)
Reptilia SELPLG 31
  • 19 (a)
OneToOne
Species where no ortholog for SELPLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SELPLG Gene

ENSEMBL:
Gene Tree for SELPLG (if available)
TreeFam:
Gene Tree for SELPLG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SELPLG: view image

Paralogs for SELPLG Gene

No data available for Paralogs for SELPLG Gene

Variants for SELPLG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELPLG Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
718350 Benign: not provided 108,623,591(-) C/T SYNONYMOUS_VARIANT
756589 Likely Benign: not provided 108,623,396(-) G/A SYNONYMOUS_VARIANT
768578 Benign: not provided 108,623,874(-) GGAGTGGTCTGTGCCT INFRAME_DELETION
787930 Benign: not provided 108,623,838(-) G/A MISSENSE_VARIANT
rs2228315 - p.Met62Ile

Additional dbSNP identifiers (rs#s) for SELPLG Gene

Structural Variations from Database of Genomic Variants (DGV) for SELPLG Gene

Variant ID Type Subtype PubMed ID
esv2746345 CNV deletion 23290073
esv3630708 CNV loss 21293372
nsv560113 CNV loss 21841781
nsv560114 CNV gain 21841781
nsv883 CNV deletion 18451855

Variation tolerance for SELPLG Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.01; 87.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELPLG Gene

Human Gene Mutation Database (HGMD)
SELPLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELPLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELPLG Gene

Disorders for SELPLG Gene

MalaCards: The human disease database

(12) MalaCards diseases for SELPLG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
human granulocytic anaplasmosis
  • hge
ehrlichiosis
  • human ehrlichiosis
thrombosis
  • thrombosis of blood vessel
leukocyte adhesion deficiency, type i
  • lad
cerebrovascular disease
  • cerebrovascular accident
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SELPLG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SELPLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELPLG Gene

Publications for SELPLG Gene

  1. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. (PMID: 19543284) Nishimura Y … Shimizu H (Nature medicine 2009) 3 4 23
  2. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik KA … Boerwinkle E (Clinical chemistry 2009) 3 23 41
  3. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PMID: 18196517) Schaff UY … Simon SI (European journal of immunology 2008) 3 4 23
  4. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 17420019) Volcik KA … Boerwinkle E (Atherosclerosis 2007) 3 23 41
  5. The association of P-selectin glycoprotein ligand-1 VNTR polymorphisms with coronary stent restenosis. (PMID: 17221329) Ozben B … Oncul A (Journal of thrombosis and thrombolysis 2007) 3 23 41

Products for SELPLG Gene

Sources for SELPLG Gene