Aliases for SELPLG Gene
External Ids for SELPLG Gene
Previous GeneCards Identifiers for SELPLG Gene
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
GeneCards Summary for SELPLG Gene
SELPLG (Selectin P Ligand) is a Protein Coding gene. Diseases associated with SELPLG include Human Granulocytic Anaplasmosis and Ehrlichiosis. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.
UniProtKB/Swiss-Prot Summary for SELPLG Gene
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
(Microbial infection) Acts as a receptor for enterovirus 71.