Aliases for SELP Gene
- Selectin P 2 3 5
- PADGEM 2 3 4
- Platelet Activation Dependent Granule-External Membrane Protein 3 4
- Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) 2 3
- Leukocyte-Endothelial Cell Adhesion Molecule 3 3 4
- CD62 Antigen-Like Family Member P 3 4
- Granule Membrane Protein 140kDa 2 3
- Granule Membrane Protein 140 3 4
- P-Selectin 3 4
- GMP-140 3 4
- GMP140 2 3
External Ids for SELP Gene
Previous HGNC Symbols for SELP Gene
Previous GeneCards Identifiers for SELP Gene
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
GeneCards Summary for SELP Gene
SELP (Selectin P) is a Protein Coding gene. Diseases associated with SELP include Intermittent Claudication and Arteriosclerosis Obliterans. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. An important paralog of this gene is SELE.
UniProtKB/Swiss-Prot Summary for SELP Gene
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.