This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that bind... See more...

Aliases for SELP Gene

Aliases for SELP Gene

  • Selectin P 2 3 5
  • PADGEM 2 3 4
  • Platelet Activation Dependent Granule-External Membrane Protein 3 4
  • Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) 2 3
  • Leukocyte-Endothelial Cell Adhesion Molecule 3 3 4
  • CD62 Antigen-Like Family Member P 3 4
  • Granule Membrane Protein 140kDa 2 3
  • Granule Membrane Protein 140 3 4
  • P-Selectin 3 4
  • GMP-140 3 4
  • GMP140 2 3
  • LECAM3 3 4
  • CD62P 2 3
  • CD62 2 3
  • GRMP 3 4
  • PSEL 2 3
  • Selectin P (Granule Membrane Protein 140kD, Antigen CD62) 2
  • Platelet Alpha-Granule Membrane Protein 3
  • Granulocyte Membrane Protein 3
  • CD62P Antigen 4
  • Antigen CD62 2
  • SELP 5
  • GMRP 4

External Ids for SELP Gene

Previous HGNC Symbols for SELP Gene

  • GRMP

Previous GeneCards Identifiers for SELP Gene

  • GC01M167186
  • GC01M165208
  • GC01M166254
  • GC01M166745
  • GC01M166290
  • GC01M167824
  • GC01M140780

Summaries for SELP Gene

Entrez Gene Summary for SELP Gene

  • This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELP Gene

SELP (Selectin P) is a Protein Coding gene. Diseases associated with SELP include Intermittent Claudication and Arteriosclerosis Obliterans. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. An important paralog of this gene is SELE.

UniProtKB/Swiss-Prot Summary for SELP Gene

  • Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

Tocris Summary for SELP Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for SELP Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELP Gene

Genomics for SELP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SELP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J169624 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 600.7 +3.5 3492 7.8 NR2F2 ID3 SELP METTL18 F5 SELE SELL lnc-F5-1
GH01J169631 Enhancer 0.2 Ensembl 600.7 -1.4 -1408 0.4 SELP C1orf112 piR-58297-032
GH01J169707 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.5 -79.5 -79502 6.2 RNF2 CTCF PRDM10 ZNF512 NFKBIZ TARDBP FOXA1 PRDM1 RELA REST MN308830 SELL lnc-SELE-1 METTL18 C1orf112 GORAB RN7SL333P F5 SELP SCYL3
GH01J169667 Enhancer 0.7 ENCODE dbSUPER 25.3 -37.5 -37473 0.7 ZNF512 YBX3 NKRF NFE2 ZNF316 MAFG NBN EMSY piR-35564-006 piR-54040-008 SELP DPT SELL METTL18 C1orf112 LOC107985745
GH01J169688 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -66.8 -66803 17.4 BRCA1 CTCF STAT3 RAD21 IKZF2 PKNOX1 EED RELB RUNX3 ZNF316 METTL18 C1orf112 SELP F5 SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B piR-56133-012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELP

Top Transcription factor binding sites by QIAGEN in the SELP gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for SELP Gene

Genomic Locations for SELP Gene
chr1:169,588,849-169,630,193
(GRCh38/hg38)
Size:
41,345 bases
Orientation:
Minus strand
chr1:169,558,087-169,599,431
(GRCh37/hg19)
Size:
41,345 bases
Orientation:
Minus strand

Genomic View for SELP Gene

Genes around SELP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELP Gene

Proteins for SELP Gene

  • Protein details for SELP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16109-LYAM3_HUMAN
    Recommended name:
    P-selectin
    Protein Accession:
    P16109
    Secondary Accessions:
    • Q5R344
    • Q8IVD1

    Protein attributes for SELP Gene

    Size:
    830 amino acids
    Molecular mass:
    90834 Da
    Quaternary structure:
    • Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG.

    Three dimensional structures from OCA and Proteopedia for SELP Gene

neXtProt entry for SELP Gene

Post-translational modifications for SELP Gene

  • Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn272, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LYAM3_HUMAN (2095)

Antibody Products

  • Abcam antibodies for SELP

No data available for DME Specific Peptides for SELP Gene

Domains & Families for SELP Gene

Gene Families for SELP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SELP Gene

InterPro:
Blocks:
  • Type I EGF
  • Sushi domain/SCR domain/CCP module
  • Selectin superfamily complement-binding repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for SELP Gene

GenScript: Design optimal peptide antigens:
  • Platelet activation dependent granule-external membrane protein (LYAM3_HUMAN)
  • Selectin P (Granule membrane protein 140kDa, antigen CD62) (Q5R348_HUMAN)
  • Selectin P (Granule membrane protein 140kDa, antigen CD62) (Q5R349_HUMAN)
  • Selectin P (Granule membrane protein 140kDa, antigen CD62) (Q5R350_HUMAN)
  • Selectin P (Granule membrane protein 140kDa, antigen CD62) (Q6NUL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16109

UniProtKB/Swiss-Prot:

LYAM3_HUMAN :
  • Belongs to the selectin/LECAM family.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELP: view

Function for SELP Gene

Molecular function for SELP Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
GENATLAS Biochemistry:
P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques

Phenotypes From GWAS Catalog for SELP Gene

Gene Ontology (GO) - Molecular Function for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IMP 16514062
GO:0005509 calcium ion binding IDA 11081633
GO:0005515 protein binding IPI 9129046
GO:0008201 heparin binding IDA 7680663
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SELP: view
genes like me logo Genes that share phenotypes with SELP: view

Animal Models for SELP Gene

MGI Knock Outs for SELP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELP Gene

Localization for SELP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELP Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELP gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4
cytoskeleton 3
nucleus 3
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 28011641
GO:0009897 external side of plasma membrane IDA 16514062
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELP Gene

Pathways & Interactions for SELP Gene

genes like me logo Genes that share pathways with SELP: view

Pathways by source for SELP Gene

SIGNOR curated interactions for SELP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IEA,TAS 2466574
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with SELP: view

Drugs & Compounds for SELP Gene

(84) Drugs for SELP Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, Target, inhibitor 1058
Nadroparin Approved, Investigational Pharma Target, inhibitor 40
Clopidogrel Approved Pharma P2Y12 receptor antagonist 934
Crizanlizumab Approved, Investigational Pharma Target, inhibitor 0
Dalteparin Approved Pharma Target, inhibitor 454

(69) Additional Compounds for SELP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-Sulfogalactosylceramide
  • Tetracosanoyl sulfatide
  • 3'-Sulphogalactosylceramide
  • 3-O-Sulphogalactosylceramide (D18:1/24:0)
  • Tetracosanoyl sulphatide
151122-71-3
Sialyl-Lewis X
  • SLex
  • Sialyl lewisx
  • Sialyl lewis-X
  • Sialyl lex
  • 3'-Sialyl-lewis X
98603-84-0
Ac2-12
256447-08-2
Ac2-26
151988-33-9
Heparin sodium salt
9041-08-1

(5) Tocris Compounds for SELP Gene

Compound Action Cas Number
Ac2-12 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 256447-08-2
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
Heparin sodium salt Anticoagulant 9041-08-1
KF 38789 Selective inhibitor of P-selectin-mediated cell adhesion 257292-29-8
PM 102 Antagonist of heparin (Cat. No. 2812) 1234564-95-4
genes like me logo Genes that share compounds with SELP: view

Transcripts for SELP Gene

mRNA/cDNA for SELP Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELP

Alternative Splicing Database (ASD) splice patterns (SP) for SELP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for SELP Gene

GeneLoc Exon Structure for
SELP

Expression for SELP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SELP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SELP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.7), Platelet (20.2), Serum (9.7), and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SELP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELP

SOURCE GeneReport for Unigene cluster for SELP Gene:

Hs.73800

mRNA Expression by UniProt/SwissProt for SELP Gene:

P16109-LYAM3_HUMAN
Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Evidence on tissue expression from TISSUES for SELP Gene

  • Blood(4.8)
  • Heart(3.8)
  • Intestine(3.1)
  • Muscle(3.1)
  • Lymph node(3)
  • Bone marrow(3)
  • Kidney(2.9)
  • Spleen(2.9)
  • Lung(2.8)
  • Liver(2.8)
  • Skin(2.8)
  • Nervous system(2.7)
  • Pancreas(2.2)
  • Bone(2.1)
  • Urine(2)
genes like me logo Genes that share expression patterns with SELP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELP Gene

Orthologs for SELP Gene

This gene was present in the common ancestor of animals.

Orthologs for SELP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SELP 30 31
  • 98.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SELP 30 31
  • 83.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SELP 31
  • 76 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Selp 30
  • 75.87 (n)
Mouse
(Mus musculus)
Mammalia Selp 30 17 31
  • 75.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SELP 31
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SELP 30 31
  • 53.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SELP 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia selp 30
  • 53.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii selp 30 31
  • 50.39 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta fw 32
  • 25 (a)
hig 31
  • 14 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T07H6.5 32
  • 27 (a)
lev-9 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10017 31
  • 26 (a)
ManyToMany
-- 31
  • 14 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
-- 31
  • 11 (a)
ManyToMany
-- 31
  • 10 (a)
ManyToMany
CSA.10029 31
  • 9 (a)
ManyToMany
Species where no ortholog for SELP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SELP Gene

ENSEMBL:
Gene Tree for SELP (if available)
TreeFam:
Gene Tree for SELP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SELP: view image

Paralogs for SELP Gene

(6) SIMAP similar genes for SELP Gene using alignment to 9 proteins:

  • LYAM3_HUMAN
  • F6VVT6_HUMAN
  • Q5R341_HUMAN
  • Q5R342_HUMAN
  • Q5R343_HUMAN
  • Q5R345_HUMAN
  • Q5R349_HUMAN
  • Q6NUL9_HUMAN
  • Q8N1E9_HUMAN
genes like me logo Genes that share paralogs with SELP: view

Variants for SELP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELP Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
738809 Likely Benign: not provided 169,596,007(-) G/A SYNONYMOUS_VARIANT
755657 Likely Benign: not provided 169,593,660(-) A/C SYNONYMOUS_VARIANT
775623 Benign: not provided 169,593,711(-) A/G SYNONYMOUS_VARIANT
775624 Benign: not provided 169,607,137(-) A/G INTRON_VARIANT
777955 Benign: not provided 169,597,027(-) A/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SELP Gene

Structural Variations from Database of Genomic Variants (DGV) for SELP Gene

Variant ID Type Subtype PubMed ID
esv22143 CNV gain+loss 19812545
esv2516985 CNV deletion 19546169
esv2658365 CNV deletion 23128226
esv2762197 CNV loss 21179565
esv3587886 CNV loss 21293372
nsv1078878 OTHER inversion 25765185
nsv472783 CNV novel sequence insertion 20440878
nsv517483 CNV loss 19592680
nsv548187 CNV loss 21841781

Variation tolerance for SELP Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELP Gene

Human Gene Mutation Database (HGMD)
SELP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELP Gene

Disorders for SELP Gene

MalaCards: The human disease database

(100) MalaCards diseases for SELP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
intermittent claudication
  • amyotrophic lateral sclerosis
arteriosclerosis obliterans
peripheral vascular disease
  • arterial occlusive disease
gray platelet syndrome
  • gps
carotid stenosis
  • carotid artery stenosis
- elite association - COSMIC cancer census association via MalaCards
Search SELP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LYAM3_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for SELP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SELP: view

No data available for Genatlas for SELP Gene

Publications for SELP Gene

  1. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PMID: 20167578) Barbalic M … Benjamin EJ (Human molecular genetics 2010) 3 23 41
  2. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik KA … Boerwinkle E (Clinical chemistry 2009) 3 23 41
  3. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PMID: 18606703) Kerr SC … Rosen SD (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 4 23
  4. Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. (PMID: 18535285) Reiner AP … Gross MD (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 23 41
  5. P-selectin polymorphisms' influences on P-selectin serum concentrations and on their familial correlation: the STANISLAS family study. (PMID: 18363816) Marteau JB … Visvikis-Siest S (Journal of thrombosis and haemostasis : JTH 2008) 3 23 41

Products for SELP Gene

Sources for SELP Gene