Aliases for SELL Gene
External Ids for SELL Gene
Previous HGNC Symbols for SELL Gene
Previous GeneCards Identifiers for SELL Gene
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for SELL Gene
SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include Arthus Reaction and Cryptococcosis. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is SELP.
UniProtKB/Swiss-Prot Summary for SELL Gene
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).