This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their mig... See more...

Aliases for SELL Gene

Aliases for SELL Gene

  • Selectin L 2 3 5
  • Leukocyte-Endothelial Cell Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member L 3 4
  • Leukocyte Surface Antigen Leu-8 3 4
  • Lymphocyte Adhesion Molecule 1 2 3
  • Lymph Node Homing Receptor 3 4
  • L-Selectin 3 4
  • Gp90-MEL 3 4
  • LECAM1 3 4
  • LYAM1 3 4
  • LNHR 3 4
  • TQ1 3 4
  • Leukocyte Adhesion Molecule 1 4
  • Pln Homing Receptor 3
  • CD62L Antigen 4
  • CD62L 3
  • PLNHR 3
  • LAM-1 4
  • LAM1 3
  • LEU8 3
  • LSEL 3

External Ids for SELL Gene

Previous HGNC Symbols for SELL Gene

  • LYAM1
  • LNHR

Previous GeneCards Identifiers for SELL Gene

  • GC01M167288
  • GC01M165310
  • GC01M166180
  • GC01M166672
  • GC01M166847
  • GC01M166391
  • GC01M167926
  • GC01M169659
  • GC01M140882

Summaries for SELL Gene

Entrez Gene Summary for SELL Gene

  • This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for SELL Gene

SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include Arthus Reaction and Cryptococcosis. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is SELP.

UniProtKB/Swiss-Prot Summary for SELL Gene

  • Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).

Gene Wiki entry for SELL Gene

Additional gene information for SELL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELL Gene

Genomics for SELL Gene

GeneHancer (GH) Regulatory Elements for SELL Gene

Promoters and enhancers for SELL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J169707 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 750.6 +2.0 2007 6.2 ZNF785 ZNF24 CTCF TRIM22 ELF1 RELA RAD21 MTA3 ZNF652 IKZF1 SELL lnc-SELE-1 METTL18 C1orf112 RN7SL333P SCYL3 GORAB SELP F5 DPT
GH01J169688 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +14.7 14706 17.4 ZNF24 CTCF ETV6 RAD21 MAFK ZNF687 IKZF1 IKZF2 PKNOX1 ZNF316 METTL18 C1orf112 SELP F5 SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B piR-56133-012
GH01J169600 Enhancer 1 Ensembl ENCODE dbSUPER 8.5 +103.2 103170 15.3 ZNF24 CTCF HLF L3MBTL2 RAD21 PRDM1 TRIM24 CEBPA REST PRDM10 METTL18 F5 SELP C1orf112 SELE SELL lnc-F5-1
GH01J169667 Enhancer 0.7 ENCODE dbSUPER 9.6 +44.0 44036 0.7 ZNF512 ZNF316 NKRF NFE2 YBX3 MAFG NBN EMSY piR-35564-006 piR-54040-008 SELP DPT SELL METTL18 C1orf112
GH01J169662 Promoter 0.6 Ensembl 9.5 +48.7 48702 1.2 L3MBTL2 MGA ZFP91 C1orf112 piR-39099-021 piR-33422-026 piR-36921-003 piR-38414-002 piR-58297-032 METTL18 SELP SELL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SELL gene promoter:
  • GR
  • GR-alpha
  • PPAR-gamma2
  • STAT3

Genomic Locations for SELL Gene

Genomic Locations for SELL Gene
chr1:169,690,665-169,711,702
(GRCh38/hg38)
Size:
21,038 bases
Orientation:
Minus strand
chr1:169,659,806-169,680,843
(GRCh37/hg19)
Size:
21,038 bases
Orientation:
Minus strand

Genomic View for SELL Gene

Genes around SELL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELL Gene

Proteins for SELL Gene

  • Protein details for SELL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14151-LYAM1_HUMAN
    Recommended name:
    L-selectin
    Protein Accession:
    P14151
    Secondary Accessions:
    • A0A024R8Z0
    • B2R6Q8
    • P15023
    • Q9UJ43

    Protein attributes for SELL Gene

    Size:
    372 amino acids
    Molecular mass:
    42187 Da
    Quaternary structure:
    • Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.

    Three dimensional structures from OCA and Proteopedia for SELL Gene

    Alternative splice isoforms for SELL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELL Gene

Post-translational modifications for SELL Gene

  • N-glycosylated.
  • Glycosylation at Asn60, Asn104, Asn177, Asn232, Asn246, and Asn271
  • Ubiquitination at Lys78, Lys93, Lys134, Lys137, and Lys141
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LYAM1_HUMAN (346)

Other Protein References for SELL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SELL

Protein Products

  • Abcam proteins for SELL

No data available for DME Specific Peptides for SELL Gene

Domains & Families for SELL Gene

Gene Families for SELL Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SELL Gene

GenScript: Design optimal peptide antigens:
  • gp90-MEL (LYAM1_HUMAN)
  • L-selectin (Q8WW79_HUMAN)
  • L-selectin (Q9UJ43_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14151

UniProtKB/Swiss-Prot:

LYAM1_HUMAN :
  • Belongs to the selectin/LECAM family.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELL: view

Function for SELL Gene

Molecular function for SELL Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
GENATLAS Biochemistry:
L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34

Phenotypes From GWAS Catalog for SELL Gene

Gene Ontology (GO) - Molecular Function for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17548643
GO:0005509 calcium ion binding IDA 28011641
GO:0005515 protein binding IPI 18606703
GO:0008201 heparin binding TAS 7680663
GO:0030246 carbohydrate binding TAS 10747985
genes like me logo Genes that share ontologies with SELL: view
genes like me logo Genes that share phenotypes with SELL: view

Animal Models for SELL Gene

MGI Knock Outs for SELL:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELL Gene

Localization for SELL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELL Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELL gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IDA,TAS 2663882
GO:0009897 external side of plasma membrane IDA --
GO:0009986 cell surface IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELL: view

Pathways & Interactions for SELL Gene

genes like me logo Genes that share pathways with SELL: view

Gene Ontology (GO) - Biological Process for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 10747985
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP 28011641
GO:0033198 response to ATP IDA --
GO:0043312 neutrophil degranulation TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SELL: view

No data available for SIGNOR curated interactions for SELL Gene

Drugs & Compounds for SELL Gene

(54) Drugs for SELL Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimosiamose Investigational Pharma inhibitor 0
GMI-1070 Pharma 0
SMART ANTI-L-SELECTIN Pharma 0

(44) Additional Compounds for SELL Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-Sulfogalactosylceramide
  • Tetracosanoyl sulfatide
  • 3'-Sulphogalactosylceramide
  • 3-O-Sulphogalactosylceramide (D18:1/24:0)
  • Tetracosanoyl sulphatide
151122-71-3
genes like me logo Genes that share compounds with SELL: view

Transcripts for SELL Gene

mRNA/cDNA for SELL Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELL Gene

No ASD Table

Relevant External Links for SELL Gene

GeneLoc Exon Structure for
SELL
ECgene alternative splicing isoforms for
SELL

Expression for SELL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELL Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for SELL Gene

This gene is overexpressed in Serum (42.7) and Plasma (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SELL Gene



NURSA nuclear receptor signaling pathways regulating expression of SELL Gene:

SELL

SOURCE GeneReport for Unigene cluster for SELL Gene:

Hs.728756

mRNA Expression by UniProt/SwissProt for SELL Gene:

P14151-LYAM1_HUMAN
Tissue specificity: Expressed in B-cell lines and T-lymphocytes.

Evidence on tissue expression from TISSUES for SELL Gene

  • Blood(5)
  • Bone marrow(4.7)
  • Spleen(4.5)
  • Lymph node(3.8)
  • Intestine(3.1)
  • Heart(2.8)
  • Lung(2.8)
  • Nervous system(2.4)
  • Skin(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SELL: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELL Gene

Orthologs for SELL Gene

This gene was present in the common ancestor of animals.

Orthologs for SELL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELL 33 32
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SELL 33 32
  • 84.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SELL 33 32
  • 84.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sell 32
  • 80.47 (n)
mouse
(Mus musculus)
Mammalia Sell 17 33 32
  • 79.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SELL 33
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SELL 33
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sele 32
  • 59.85 (n)
zebrafish
(Danio rerio)
Actinopterygii selp 33
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 33
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lev-9 33
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10017 33
  • 8 (a)
ManyToMany
-- 33
  • 5 (a)
ManyToMany
-- 33
  • 4 (a)
ManyToMany
-- 33
  • 4 (a)
ManyToMany
-- 33
  • 4 (a)
ManyToMany
CSA.10029 33
  • 3 (a)
ManyToMany
Species where no ortholog for SELL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELL Gene

ENSEMBL:
Gene Tree for SELL (if available)
TreeFam:
Gene Tree for SELL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SELL: view image

Paralogs for SELL Gene

(2) SIMAP similar genes for SELL Gene using alignment to 2 proteins:

  • LYAM1_HUMAN
  • Q8WW79_HUMAN
genes like me logo Genes that share paralogs with SELL: view

Variants for SELL Gene

Sequence variations from dbSNP and Humsavar for SELL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000152051 -- 169,692,717(-) A/G intron_variant
rs1000309026 -- 169,708,874(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000319323 -- 169,692,285(-) G/C/T intron_variant
rs1000394800 -- 169,702,228(-) G/A intron_variant
rs1000435304 -- 169,692,002(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SELL Gene

Variant ID Type Subtype PubMed ID
nsv1009313 CNV loss 25217958
nsv1078878 OTHER inversion 25765185
nsv819234 CNV gain 19587683
nsv952232 CNV duplication 24416366

Variation tolerance for SELL Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.83; 93.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELL Gene

Human Gene Mutation Database (HGMD)
SELL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELL Gene

Disorders for SELL Gene

MalaCards: The human disease database

(35) MalaCards diseases for SELL Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthus reaction
  • arthus phenomenon
cryptococcosis
  • busse-buschke's disease
granulocytopenia
  • agranulocytosis
leukocyte adhesion deficiency, type i
  • lad
periodontosis
  • periodontitis, juvenile
- elite association - COSMIC cancer census association via MalaCards
Search SELL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SELL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SELL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELL Gene

Publications for SELL Gene

  1. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PMID: 12736247) Leppänen A … Cummings RD (The Journal of biological chemistry 2003) 3 4 23 56
  2. Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PMID: 1692315) Ord DC … Tedder TF (The Journal of biological chemistry 1990) 3 4 23 56
  3. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PMID: 2664786) Siegelman MH … Weissman IL (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4 56
  4. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. (PMID: 28011641) Mehta-D'souza P … McEver RP (The Journal of biological chemistry 2017) 3 4 56
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56

Products for SELL Gene

Sources for SELL Gene