Aliases for SELL Gene
External Ids for SELL Gene
Previous HGNC Symbols for SELL Gene
Previous GeneCards Identifiers for SELL Gene
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for SELL Gene
SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include Arthus Reaction and Cryptococcosis. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is SELP.
UniProtKB/Swiss-Prot Summary for SELL Gene
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).