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Aliases for SELENOW Gene

Aliases for SELENOW Gene

  • Selenoprotein W 2 3 4 5
  • Selenoprotein W, 1 2 3
  • SEPW1 3 4
  • SelW 3 4
  • SELW 4

External Ids for SELENOW Gene

Previous HGNC Symbols for SELENOW Gene

  • SEPW1

Summaries for SELENOW Gene

Entrez Gene Summary for SELENOW Gene

  • This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]

GeneCards Summary for SELENOW Gene

SELENOW (Selenoprotein W) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins. An important paralog of this gene is SELENOV.

UniProtKB/Swiss-Prot for SELENOW Gene

  • Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Wiki entry for SELENOW Gene

Additional gene information for SELENOW Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOW Gene

Genomics for SELENOW Gene

GeneHancer (GH) Regulatory Elements for SELENOW Gene

Promoters and enhancers for SELENOW Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047775 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 643.1 +0.1 141 5.5 SP1 ZFX ELF3 ZNF148 NKRF POLR2A ZNF121 GTF2F1 ZNF687 AHR SELENOW ZC3H4 BICRA GRWD1 NOP53 NOP53-AS1 KDELR1 RPL18 INAFM1 CCDC9
GH19J047607 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.1 -167.8 -167816 7.5 SP1 ZFX ZNF148 NKRF MLLT1 POLR2A GTF2F1 FOS ZBTB7A YY1 SELENOW ZNF541 ZC3H4 MEIS3 CCDC9 LIG1 KPTN ENSG00000268746 ENSG00000277383 BICRA
GH19J047741 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.5 -34.5 -34481 5.4 SP1 ZFX CTCF ELF3 MNT SIX5 ZNF148 NKRF POLR2A MLLT1 NOP53 ZC3H4 BICRA SELENOW GRWD1 RASIP1 CA11 ENSG00000268093 ZSWIM9 NOP53-AS1
GH19J047774 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 42.8 -4.4 -4384 0.8 ELF3 ZNF121 CEBPG TFE3 CEBPA SOX13 FOXA2 ZFHX2 NFIL3 DMAP1 GC19P047775 SELENOW NOP53 PLA2G4C CARD8 SLC8A2 NOP53-AS1
GH19J047765 Enhancer 1.1 Ensembl ENCODE dbSUPER 38.9 -12.6 -12642 1.1 CTCF RAD21 GLIS2 PKNOX1 ARID2 ZNF143 REST SMC3 GABPB1 ZFHX2 SELENOW NOP53-AS1 SNORD23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOW on UCSC Golden Path with GeneCards custom track

Genomic Locations for SELENOW Gene

Genomic Locations for SELENOW Gene
chr19:47,778,585-47,784,686
(GRCh38/hg38)
Size:
6,102 bases
Orientation:
Plus strand
chr19:48,281,829-48,287,943
(GRCh37/hg19)
Size:
6,115 bases
Orientation:
Plus strand

Genomic View for SELENOW Gene

Genes around SELENOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOW Gene

Proteins for SELENOW Gene

  • Protein details for SELENOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63302-SELW_HUMAN
    Recommended name:
    Selenoprotein W
    Protein Accession:
    P63302
    Secondary Accessions:
    • A8MRR7
    • O15532
    • O19096
    • Q86TI9
    • Q96KM5

    Protein attributes for SELENOW Gene

    Size:
    87 amino acids
    Molecular mass:
    9448 Da
    Quaternary structure:
    • Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.

neXtProt entry for SELENOW Gene

Post-translational modifications for SELENOW Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOW Gene

No data available for DME Specific Peptides for SELENOW Gene

Domains & Families for SELENOW Gene

Gene Families for SELENOW Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SELENOW Gene

Suggested Antigen Peptide Sequences for SELENOW Gene

GenScript: Design optimal peptide antigens:
  • Selenoprotein W (SELW_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63302

UniProtKB/Swiss-Prot:

SELW_HUMAN :
  • Belongs to the SelWTH family. Selenoprotein W subfamily.
Family:
  • Belongs to the SelWTH family. Selenoprotein W subfamily.
genes like me logo Genes that share domains with SELENOW: view

Function for SELENOW Gene

Molecular function for SELENOW Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Phenotypes From GWAS Catalog for SELENOW Gene

Gene Ontology (GO) - Molecular Function for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with SELENOW: view
genes like me logo Genes that share phenotypes with SELENOW: view

Animal Models for SELENOW Gene

MGI Knock Outs for SELENOW:
  • Selenow Selenow<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for SELENOW Gene

miRTarBase miRNAs that target SELENOW

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOW

Clone Products

  • Applied Biological Materials (abm): Clones for SELENOW - Now 50% OFF >
  • * SELENOW as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SELENOW tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELENOW Gene

Localization for SELENOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOW Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOW gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with SELENOW: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELENOW Gene

Pathways & Interactions for SELENOW Gene

genes like me logo Genes that share pathways with SELENOW: view

Pathways by source for SELENOW Gene

Interacting Proteins for SELENOW Gene

Gene Ontology (GO) - Biological Process for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion IBA 21873635
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with SELENOW: view

No data available for SIGNOR curated interactions for SELENOW Gene

Drugs & Compounds for SELENOW Gene

(3) Drugs for SELENOW Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 216
Selenocysteine Experimental Pharma 0

(1) Additional Compounds for SELENOW Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENOW: view

Transcripts for SELENOW Gene

mRNA/cDNA for SELENOW Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOW

Clone Products

  • Applied Biological Materials (abm): Clones for SELENOW - Now 50% OFF >
  • * SELENOW as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SELENOW tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOW Gene

No ASD Table

Relevant External Links for SELENOW Gene

GeneLoc Exon Structure for
SELENOW
ECgene alternative splicing isoforms for
SELENOW

Expression for SELENOW Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENOW Gene:

SELENOW

mRNA Expression by UniProt/SwissProt for SELENOW Gene:

P63302-SELW_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.

Evidence on tissue expression from TISSUES for SELENOW Gene

  • Nervous system(5)
  • Muscle(4.7)
  • Heart(3.5)
  • Lung(3.3)
  • Eye(2.9)
  • Pancreas(2.9)
  • Skin(2.7)
  • Intestine(2.5)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Kidney(2.3)
  • Liver(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with SELENOW: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOW Gene

Orthologs for SELENOW Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPW1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia SEPW1 35 34
  • 91.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SEPW1 34 35
  • 90.04 (n)
rat
(Rattus norvegicus)
Mammalia Sepw1 34
  • 88.76 (n)
mouse
(Mus musculus)
Mammalia Sepw1 34 35
  • 87.21 (n)
Selenow 17
platypus
(Ornithorhynchus anatinus)
Mammalia SEPW1 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPW1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPW1 34
  • 65.48 (n)
lizard
(Anolis carolinensis)
Reptilia SEPW1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.76 34
zebrafish
(Danio rerio)
Actinopterygii sepw1 35 34
  • 64.73 (n)
OneToMany
-- 34
Species where no ortholog for SELENOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOW Gene

ENSEMBL:
Gene Tree for SELENOW (if available)
TreeFam:
Gene Tree for SELENOW (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SELENOW: view image

Paralogs for SELENOW Gene

Paralogs for SELENOW Gene

Pseudogenes.org Pseudogenes for SELENOW Gene

genes like me logo Genes that share paralogs with SELENOW: view

Variants for SELENOW Gene

Sequence variations from dbSNP and Humsavar for SELENOW Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000140609 -- 47,778,744(+) G/A/T 5_prime_UTR_variant
rs1000162461 -- 47,781,861(+) G/A intron_variant
rs1000501732 -- 47,780,824(+) C/T intron_variant
rs1000959177 -- 47,776,941(+) C/G/T upstream_transcript_variant
rs1000979112 -- 47,781,088(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOW Gene

Variant ID Type Subtype PubMed ID
esv3644559 CNV gain 21293372
nsv1058351 CNV gain 25217958
nsv1062085 CNV gain 25217958
nsv482046 CNV loss 20164927
nsv520073 CNV gain 19592680

Variation tolerance for SELENOW Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOW Gene

Disorders for SELENOW Gene

Additional Disease Information for SELENOW

No disorders were found for SELENOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOW Gene

Publications for SELENOW Gene

  1. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. (PMID: 12818432) Bellingham J … Gregory-Evans CY (Biochimica et biophysica acta 2003) 3 4 23 58
  2. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. (PMID: 9256076) Gu QP … Whanger PD (Gene 1997) 2 3 4 58
  3. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 58
  4. Selenoprotein W modulates control of cell cycle entry. (PMID: 19387567) Hawkes WC … Dawson K (Biological trace element research 2009) 3 23 58
  5. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. (PMID: 15823556) Kim YJ … Ryu JC (Biochemical and biophysical research communications 2005) 3 23 58

Products for SELENOW Gene

  • Biorbyt antibodies for SELENOW

Sources for SELENOW Gene

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