Aliases for SELENOW Gene
External Ids for SELENOW Gene
Previous HGNC Symbols for SELENOW Gene
Previous GeneCards Identifiers for SELENOW Gene
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
GeneCards Summary for SELENOW Gene
SELENOW (Selenoprotein W) is a Protein Coding gene. Diseases associated with SELENOW include Keshan Disease and Rigid Spine Muscular Dystrophy 1. Among its related pathways are Folate Metabolism. An important paralog of this gene is SELENOV.
UniProtKB/Swiss-Prot Summary for SELENOW Gene
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).