This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protei... See more...

Aliases for SELENOV Gene

Aliases for SELENOV Gene

  • Selenoprotein V 2 3 4 5
  • SELV 3 4
  • SelV 4

External Ids for SELENOV Gene

Summaries for SELENOV Gene

Entrez Gene Summary for SELENOV Gene

  • This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]

GeneCards Summary for SELENOV Gene

SELENOV (Selenoprotein V) is a Protein Coding gene. Diseases associated with SELENOV include Staphyloenterotoxemia and Syndromic X-Linked Intellectual Disability Cabezas Type. Among its related pathways are Selenium Metabolism and Selenoproteins and Folate Metabolism. An important paralog of this gene is SELENOW.

UniProtKB/Swiss-Prot Summary for SELENOV Gene

Additional gene information for SELENOV Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELENOV Gene

Genomics for SELENOV Gene

GeneHancer (GH) Regulatory Elements for SELENOV Gene

Promoters and enhancers for SELENOV Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039514 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.6 618 2.1 RBAK ZNF639 ZBTB10 GABPA ZBTB26 ZBTB7A EZH2 ZNF341 POLR2A HDAC2 SELENOV EID2B MED29 RPS16 SPTBN4 EID2 lnc-EID2B-1
GH19J039518 Enhancer 0.9 Ensembl ENCODE 0.7 +4.5 4527 2.5 NFRKB RBM25 WT1 ZNF316 NFIC MAFF MAFK BCOR GATA3 ZNF335 RPS16 SELENOV lnc-EID2B-1
GH19J039524 Enhancer 0.8 Ensembl ENCODE 0.4 +9.7 9687 1.2 WT1 SP2 POLR2A ZFHX2 BATF KLF17 SMARCA4 KLF16 PBX3 SPI1 lnc-EID2B-1 RPS16 SELENOV
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOV on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELENOV

Genomic Locations for SELENOV Gene

Genomic Locations for SELENOV Gene
chr19:39,515,113-39,520,686
(GRCh38/hg38)
Size:
5,574 bases
Orientation:
Plus strand
chr19:40,005,753-40,011,326
(GRCh37/hg19)
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for SELENOV Gene

Genes around SELENOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOV Gene

Proteins for SELENOV Gene

  • Protein details for SELENOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59797-SELV_HUMAN
    Recommended name:
    Selenoprotein V
    Protein Accession:
    P59797
    Secondary Accessions:
    • Q17RG5

    Protein attributes for SELENOV Gene

    Size:
    346 amino acids
    Molecular mass:
    36800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOV Gene

Post-translational modifications for SELENOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOV Gene

No data available for DME Specific Peptides for SELENOV Gene

Domains & Families for SELENOV Gene

Gene Families for SELENOV Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SELENOV Gene

Suggested Antigen Peptide Sequences for SELENOV Gene

GenScript: Design optimal peptide antigens:
  • Selenoprotein V (SELV_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59797

UniProtKB/Swiss-Prot:

SELV_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with SELENOV: view

Function for SELENOV Gene

Molecular function for SELENOV Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for SELENOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOV: view
genes like me logo Genes that share phenotypes with SELENOV: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOV

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOV Gene

Localization for SELENOV Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOV gene
Compartment Confidence
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SELENOV Gene

Pathways & Interactions for SELENOV Gene

genes like me logo Genes that share pathways with SELENOV: view

Pathways by source for SELENOV Gene

Gene Ontology (GO) - Biological Process for SELENOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion IBA 21873635
genes like me logo Genes that share ontologies with SELENOV: view

No data available for SIGNOR curated interactions for SELENOV Gene

Drugs & Compounds for SELENOV Gene

No Compound Related Data Available

Transcripts for SELENOV Gene

mRNA/cDNA for SELENOV Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOV

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOV Gene

No ASD Table

Relevant External Links for SELENOV Gene

GeneLoc Exon Structure for
SELENOV

Expression for SELENOV Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELENOV

mRNA Expression by UniProt/SwissProt for SELENOV Gene:

P59797-SELV_HUMAN
Tissue specificity: Testis specific.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOV Gene

Orthologs for SELENOV Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELV 31 30
  • 99.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102151122 30
  • 72 (n)
-- 31
  • 16 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selv 30
  • 60.34 (n)
mouse
(Mus musculus)
Mammalia BC089491 31 30
  • 59.3 (n)
OneToOne
Selenov 17
cow
(Bos Taurus)
Mammalia SELV 31
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sepw1 31
  • 47 (a)
OneToMany
Species where no ortholog for SELENOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOV Gene

ENSEMBL:
Gene Tree for SELENOV (if available)
TreeFam:
Gene Tree for SELENOV (if available)

Paralogs for SELENOV Gene

Paralogs for SELENOV Gene

genes like me logo Genes that share paralogs with SELENOV: view

Variants for SELENOV Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELENOV Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs56149652 - p.Lys284Arg

Additional dbSNP identifiers (rs#s) for SELENOV Gene

Structural Variations from Database of Genomic Variants (DGV) for SELENOV Gene

Variant ID Type Subtype PubMed ID
esv3644330 CNV loss 21293372
nsv522811 CNV loss 19592680
nsv579509 CNV gain 21841781
nsv953573 CNV deletion 24416366

Variation tolerance for SELENOV Gene

Gene Damage Index Score: 3.58; 56.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOV Gene

Disorders for SELENOV Gene

MalaCards: The human disease database

(2) MalaCards diseases for SELENOV Gene - From: DISEASES

Disorder Aliases PubMed IDs
staphyloenterotoxemia
  • staphylococcal food poisoning
syndromic x-linked intellectual disability cabezas type
  • mrxsc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SELENOV

genes like me logo Genes that share disorders with SELENOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOV Gene

Publications for SELENOV Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 2 3 4 54
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. [Effect of Sodium Selenite on Gene Expression of SELF, SELW, and TGR Selenoproteins in Adenocarcinoma Cells of the Human Prostate]. (PMID: 29989584) Varlamova EG … Kuznetsova JP (Molekuliarnaia biologiia 2018) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for SELENOV Gene

Sources for SELENOV Gene