This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepat... See more...

Aliases for SELENOP Gene

Aliases for SELENOP Gene

  • Selenoprotein P 2 3 4 5
  • Selenoprotein P, Plasma, 1 2 3
  • SEPP1 3 4
  • SELP 3 4
  • SeP 3 4
  • SEPP 3

External Ids for SELENOP Gene

Previous HGNC Symbols for SELENOP Gene

  • SEPP1

Summaries for SELENOP Gene

Entrez Gene Summary for SELENOP Gene

  • This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]

GeneCards Summary for SELENOP Gene

SELENOP (Selenoprotein P) is a Protein Coding gene. Diseases associated with SELENOP include Keshan Disease and Colorectal Adenoma. Among its related pathways are Focal Adhesion and Response to elevated platelet cytosolic Ca2+.

UniProtKB/Swiss-Prot Summary for SELENOP Gene

  • Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Gene Wiki entry for SELENOP Gene

Additional gene information for SELENOP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELENOP Gene

Genomics for SELENOP Gene

GeneHancer (GH) Regulatory Elements for SELENOP Gene

Promoters and enhancers for SELENOP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELENOP

Genomic Locations for SELENOP Gene

Genomic Locations for SELENOP Gene
chr5:42,799,880-42,887,392
(GRCh38/hg38)
Size:
87,513 bases
Orientation:
Minus strand
chr5:42,799,982-42,887,494
(GRCh37/hg19)
Size:
87,513 bases
Orientation:
Minus strand

Genomic View for SELENOP Gene

Genes around SELENOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOP Gene

Proteins for SELENOP Gene

  • Protein details for SELENOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49908-SEPP1_HUMAN
    Recommended name:
    Selenoprotein P
    Protein Accession:
    P49908
    Secondary Accessions:
    • Q6PD59
    • Q6PI43
    • Q6PI87
    • Q6PJF9

    Protein attributes for SELENOP Gene

    Size:
    381 amino acids
    Molecular mass:
    43174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOP Gene

Post-translational modifications for SELENOP Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Glycosylation at Asn46, Asn83, Asn119, Asn128, Asn174, and Asn338
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SEPP1_HUMAN (1729)

Other Protein References for SELENOP Gene

No data available for DME Specific Peptides for SELENOP Gene

Domains & Families for SELENOP Gene

Gene Families for SELENOP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SELENOP Gene

Blocks:
  • Selenoprotein P, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELENOP Gene

GenScript: Design optimal peptide antigens:
  • Selenoprotein P (SEPP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49908

UniProtKB/Swiss-Prot:

SEPP1_HUMAN :
  • The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.
  • Belongs to the selenoprotein P family.
Domain:
  • The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.
Family:
  • Belongs to the selenoprotein P family.
genes like me logo Genes that share domains with SELENOP: view

Function for SELENOP Gene

Molecular function for SELENOP Gene

UniProtKB/Swiss-Prot Function:
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Phenotypes From GWAS Catalog for SELENOP Gene

Gene Ontology (GO) - Molecular Function for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with SELENOP: view
genes like me logo Genes that share phenotypes with SELENOP: view

Animal Models for SELENOP Gene

MGI Knock Outs for SELENOP:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOP Gene

Localization for SELENOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOP Gene

Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250 UniProtKB:P70274}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOP gene
Compartment Confidence
extracellular 4
plasma membrane 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IEA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with SELENOP: view

Pathways & Interactions for SELENOP Gene

genes like me logo Genes that share pathways with SELENOP: view

Interacting Proteins for SELENOP Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 14)
STRING Interaction Network
Selected Interacting proteins: ENSP00000420939 P49908-SEPP1_HUMAN for SELENOP Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IBA 21873635
GO:0002576 platelet degranulation TAS --
GO:0006979 response to oxidative stress TAS 2037562
GO:0007420 brain development IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with SELENOP: view

No data available for SIGNOR curated interactions for SELENOP Gene

Drugs & Compounds for SELENOP Gene

(12) Drugs for SELENOP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 226
Selenious acid Approved, Investigational Pharma Transporter 16
Zinc Approved, Investigational Pharma Target 2822
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(13) Additional Compounds for SELENOP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENOP: view

Transcripts for SELENOP Gene

mRNA/cDNA for SELENOP Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOP Gene

No ASD Table

Relevant External Links for SELENOP Gene

GeneLoc Exon Structure for
SELENOP

Expression for SELENOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELENOP

mRNA Expression by UniProt/SwissProt for SELENOP Gene:

P49908-SEPP1_HUMAN
Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

Evidence on tissue expression from TISSUES for SELENOP Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Heart(4.2)
  • Bone marrow(4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with SELENOP: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOP Gene

Orthologs for SELENOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPP1 30
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia SEPP1 31 30
  • 85.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SEPP1 30
  • 83.2 (n)
rat
(Rattus norvegicus)
Mammalia Sepp1 30
  • 79.32 (n)
mouse
(Mus musculus)
Mammalia Sepp1 31 30
  • 77.78 (n)
OneToOne
Selenop 17
platypus
(Ornithorhynchus anatinus)
Mammalia SEPP1 31
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPP1 31
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPP1 31 30
  • 63.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPP1 31
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sepp1 30
  • 61.3 (n)
Str.5371 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.28822 30
zebrafish
(Danio rerio)
Actinopterygii sepp1a 31 30
  • 51.34 (n)
OneToOne
Species where no ortholog for SELENOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOP Gene

ENSEMBL:
Gene Tree for SELENOP (if available)
TreeFam:
Gene Tree for SELENOP (if available)

Paralogs for SELENOP Gene

No data available for Paralogs for SELENOP Gene

Variants for SELENOP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELENOP Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
747158 Likely Benign: not provided 42,808,299(-) T/TC FRAMESHIFT_VARIANT
783435 Benign: not provided 42,801,176(-) T/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
787815 Benign: not provided 42,806,886(-) A/G INTRON_VARIANT
rs28919895 - p.Pro112Ser
rs28919923 - p.Arg278Gln

Additional dbSNP identifiers (rs#s) for SELENOP Gene

Structural Variations from Database of Genomic Variants (DGV) for SELENOP Gene

Variant ID Type Subtype PubMed ID
dgv5637n100 CNV gain 25217958
nsv462126 CNV gain 19166990
nsv523033 CNV gain 19592680
nsv597886 CNV gain 21841781
nsv597925 CNV gain 21841781

Variation tolerance for SELENOP Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOP Gene

Human Gene Mutation Database (HGMD)
SELENOP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOP Gene

Disorders for SELENOP Gene

MalaCards: The human disease database

(3) MalaCards diseases for SELENOP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
keshan disease
  • caused by deficiency of selenium in the diet
colorectal adenoma
  • colorectal adenomas
pontocerebellar hypoplasia, type 2d
  • pch2d
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SELENOP

genes like me logo Genes that share disorders with SELENOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOP Gene

Publications for SELENOP Gene

  1. Selenoprotein P: properties, functions, and regulation. (PMID: 10775431) Mostert V (Archives of biochemistry and biophysics 2000) 3 4 23 54
  2. A novel method for the purification of selenoprotein P from human plasma. (PMID: 9735174) Mostert V … Abel J (Archives of biochemistry and biophysics 1998) 3 4 23 54
  3. Purification of selenoprotein P from human plasma. (PMID: 8142465) Akesson B … Burk RF (Biochimica et biophysica acta 1994) 3 4 23 54
  4. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PMID: 7931697) Burk RF … Hill KE (The Journal of nutrition 1994) 3 4 23 54
  5. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. (PMID: 8421687) Hill KE … Burk RF (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 54

Products for SELENOP Gene

Sources for SELENOP Gene