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Aliases for SELENOM Gene

Aliases for SELENOM Gene

  • Selenoprotein M 2 3 4 5
  • SELM 3 4
  • Selenoprotein SelM 3
  • SEPM 3
  • SelM 4

External Ids for SELENOM Gene

Summaries for SELENOM Gene

Entrez Gene Summary for SELENOM Gene

  • The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

GeneCards Summary for SELENOM Gene

SELENOM (Selenoprotein M) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins. An important paralog of this gene is SELENOF.

UniProtKB/Swiss-Prot for SELENOM Gene

  • May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Additional gene information for SELENOM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOM Gene

Genomics for SELENOM Gene

GeneHancer (GH) Regulatory Elements for SELENOM Gene

Promoters and enhancers for SELENOM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J031121 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 607.6 -1.9 -1933 4 NFIB ZBTB7A YY1 POLR2A ZNF548 KLF14 PRDM1 CREB1 GLIS2 ZNF600 SELENOM LOC105372995 INPP5J TUG1 SFI1 SF3A1 MORC2 PATZ1 RNF215
GH22J031118 Enhancer 0.9 Ensembl ENCODE dbSUPER 615.1 +0.9 948 1.4 ZNF24 MNT ZMYM3 PRDM10 KDM1A SELENOM PLA2G3 ENSG00000214125 RNF185 LOC105372995 ENSG00000235573 INPP5J
GH22J031077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.7 +37.2 37172 10.3 ZNF652 SP1 ZFX ELF3 CTCF ZNF148 NKRF POLR2A CEBPG ZNF687 SMTN ENSG00000273387 TUG1 MORC2 SF3A1 SELENOM PES1 INPP5J TBC1D10A PRR14L
GH22J031097 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 17.5 +16.9 16869 10.8 ZFX CC2D1A CTCF ZNF148 CEBPG MAFK SP7 SP1 PPARG SP5 TUG1 MORC2 RNF185 SF3A1 PRR14L DEPDC5 PES1 SELENOM PATZ1 RNF215
GH22J031062 Promoter/Enhancer 1.6 Ensembl ENCODE 19.8 +56.4 56368 2.6 GTF2F1 YY1 SP7 ZNF644 ZNF639 KAT8 PRDM10 REST ZNF692 HDAC1 SMTN SELENOM MORC2 INPP5J TUG1 PES1 TCN2 ENSG00000223831 RN7SL633P ENSG00000278920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOM on UCSC Golden Path with GeneCards custom track

Genomic Locations for SELENOM Gene

Genomic Locations for SELENOM Gene
chr22:31,104,772-31,120,069
(GRCh38/hg38)
Size:
15,298 bases
Orientation:
Minus strand
chr22:31,500,758-31,516,055
(GRCh37/hg19)
Size:
15,298 bases
Orientation:
Minus strand

Genomic View for SELENOM Gene

Genes around SELENOM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOM Gene

Proteins for SELENOM Gene

  • Protein details for SELENOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX9-SELM_HUMAN
    Recommended name:
    Selenoprotein M
    Protein Accession:
    Q8WWX9
    Secondary Accessions:
    • A8MPZ2

    Protein attributes for SELENOM Gene

    Size:
    145 amino acids
    Molecular mass:
    16232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOM Gene

Post-translational modifications for SELENOM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOM Gene

Domains & Families for SELENOM Gene

Gene Families for SELENOM Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SELENOM Gene

Suggested Antigen Peptide Sequences for SELENOM Gene

GenScript: Design optimal peptide antigens:
  • Selenoprotein M (SELM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWX9

UniProtKB/Swiss-Prot:

SELM_HUMAN :
  • Belongs to the selenoprotein M/F family.
Family:
  • Belongs to the selenoprotein M/F family.
genes like me logo Genes that share domains with SELENOM: view

Function for SELENOM Gene

Molecular function for SELENOM Gene

UniProtKB/Swiss-Prot Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Phenotypes From GWAS Catalog for SELENOM Gene

Gene Ontology (GO) - Molecular Function for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOM: view
genes like me logo Genes that share phenotypes with SELENOM: view

Animal Models for SELENOM Gene

MGI Knock Outs for SELENOM:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SELENOM - Now 50% OFF >
  • * SELENOM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SELENOM tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOM Gene

Localization for SELENOM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOM Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOM gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
extracellular 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SELENOM: view

Pathways & Interactions for SELENOM Gene

genes like me logo Genes that share pathways with SELENOM: view

Pathways by source for SELENOM Gene

Interacting Proteins for SELENOM Gene

Gene Ontology (GO) - Biological Process for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion IEA --
GO:0035264 multicellular organism growth IEA --
GO:0035934 corticosterone secretion IEA --
GO:0042445 hormone metabolic process IEA --
GO:0060612 adipose tissue development IEA --
genes like me logo Genes that share ontologies with SELENOM: view

No data available for SIGNOR curated interactions for SELENOM Gene

Drugs & Compounds for SELENOM Gene

(2) Drugs for SELENOM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 216
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOM: view

Transcripts for SELENOM Gene

mRNA/cDNA for SELENOM Gene

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SELENOM - Now 50% OFF >
  • * SELENOM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SELENOM tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOM Gene

No ASD Table

Relevant External Links for SELENOM Gene

GeneLoc Exon Structure for
SELENOM
ECgene alternative splicing isoforms for
SELENOM

Expression for SELENOM Gene

mRNA Expression by UniProt/SwissProt for SELENOM Gene:

Q8WWX9-SELM_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SELENOM Gene

  • Nervous system(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with SELENOM: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOM Gene

Orthologs for SELENOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELM 35 34
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SELM 34
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Selm 35 34
  • 84.59 (n)
OneToOne
Selenom 17
cow
(Bos Taurus)
Mammalia SELM 35 34
  • 83.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selm 34
  • 83.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELM 35 34
  • 75.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selm 34
  • 64.51 (n)
Str.10296 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16264 34
zebrafish
(Danio rerio)
Actinopterygii selm 35 34
  • 66.67 (n)
OneToOne
sepm 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8755 34
Species where no ortholog for SELENOM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOM Gene

ENSEMBL:
Gene Tree for SELENOM (if available)
TreeFam:
Gene Tree for SELENOM (if available)

Paralogs for SELENOM Gene

Paralogs for SELENOM Gene

genes like me logo Genes that share paralogs with SELENOM: view

Variants for SELENOM Gene

Sequence variations from dbSNP and Humsavar for SELENOM Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000329869 -- 31,106,739(-) T/G intron_variant
rs1000942217 -- 31,104,743(-) A/C downstream_transcript_variant
rs1001835513 -- 31,107,023(-) A/C/G/T intron_variant
rs1002377514 -- 31,106,815(-) G/A intron_variant
rs1002653855 -- 31,106,783(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOM Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829173 CNV loss 20364138
nsv953069 CNV deletion 24416366
nsv9896 CNV gain 18304495

Variation tolerance for SELENOM Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOM Gene

Disorders for SELENOM Gene

Additional Disease Information for SELENOM

No disorders were found for SELENOM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOM Gene

Publications for SELENOM Gene

  1. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. (PMID: 11839807) Korotkov KV … Gladyshev VN (Molecular and cellular biology 2002) 2 3 4 23 58
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SELENOM Gene

Sources for SELENOM Gene

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