Aliases for SELENOI Gene
External Ids for SELENOI Gene
Previous HGNC Symbols for SELENOI Gene
The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
GeneCards Summary for SELENOI Gene
SELENOI (Selenoprotein I) is a Protein Coding gene. Diseases associated with SELENOI include Autosomal Recessive Complex Spastic Paraplegia Due To Kennedy Pathway Dysfunction. Among its related pathways are Selenium Micronutrient Network and Glycerophospholipid biosynthesis. An important paralog of this gene is CEPT1.
UniProtKB/Swiss-Prot Summary for SELENOI Gene
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.