The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein ... See more...

Aliases for SELENOF Gene

Aliases for SELENOF Gene

  • Selenoprotein F 2 3 4 5
  • 15 KDa Selenoprotein 3 4
  • SEP15 3 4
  • Selenoprotein F (15kDa) 2

External Ids for SELENOF Gene

Summaries for SELENOF Gene

Entrez Gene Summary for SELENOF Gene

  • The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

GeneCards Summary for SELENOF Gene

SELENOF (Selenoprotein F) is a Protein Coding gene. Among its related pathways are Folate Metabolism. An important paralog of this gene is SELENOM.

UniProtKB/Swiss-Prot Summary for SELENOF Gene

  • May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556).

Gene Wiki entry for SELENOF Gene

Additional gene information for SELENOF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELENOF Gene

Genomics for SELENOF Gene

GeneHancer (GH) Regulatory Elements for SELENOF Gene

Promoters and enhancers for SELENOF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J086912 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.4 -377 4.8 HNRNPK ZBTB40 EP300 SIN3A NRF1 TCF12 MYC POLR2G USF1 SP1 HS2ST1 SELENOF lnc-SELENOF-6 ENSG00000261737 ENSG00000267734
GH01J086937 Enhancer 0.7 Ensembl 12.5 -24.6 -24577 2 MYC NFIC ARNT PBX2 ZNF184 MNT FOXM1 EP400 PRDM6 DPF2 HS2ST1 SELENOF ENSG00000261737 SH3GLB1 ENSG00000267734 lnc-SELENOF-1
GH01J087115 Enhancer 0.8 Ensembl ENCODE 5.9 -202.5 -202477 3.8 JUND EP300 ZNF341 NFIC FOS SRF MEF2B RBM22 NBN IKZF1 ENSG00000261737 SELENOF lnc-HS2ST1-3 LINC01140 ENSG00000267561
GH01J086971 Enhancer 0.7 Ensembl ENCODE 6.4 -57.5 -57515 1.5 NFIC FOS JUND NR2F2 IRF2 GATA3 RXRA ATF4 HNF4A NFIA piR-57138-012 ENSG00000261737 SELENOF HS2ST1 piR-50094-001
GH01J086997 Enhancer 0.6 Ensembl 6.4 -83.3 -83277 1.4 ZSCAN5C OSR2 ZFHX2 ZNF318 EGR1 GATA2 PRDM6 FEZF1 CEBPB EGR2 ENSG00000261737 SELENOF ENSG00000267561 ENSG00000235251 lnc-SELENOF-8 HS2ST1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOF on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELENOF

Genomic Locations for SELENOF Gene

Genomic Locations for SELENOF Gene
chr1:86,862,445-86,914,424
(GRCh38/hg38)
Size:
51,980 bases
Orientation:
Minus strand
chr1:87,328,128-87,380,107
(GRCh37/hg19)
Size:
51,980 bases
Orientation:
Minus strand

Genomic View for SELENOF Gene

Genes around SELENOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOF Gene

Proteins for SELENOF Gene

  • Protein details for SELENOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60613-SEP15_HUMAN
    Recommended name:
    Selenoprotein F
    Protein Accession:
    O60613
    Secondary Accessions:
    • A0A0B4J1S4
    • Q4GZG7
    • Q8WU00
    • Q9BS64
    • Q9GZW0
    • Q9NR01

    Protein attributes for SELENOF Gene

    Size:
    165 amino acids
    Molecular mass:
    18092 Da
    Quaternary structure:
    • Forms a tight complex with UGGT1/UGCGL1 (PubMed:24415556). Interacts with UGGT2/UGCGL2 (PubMed:24415556). Interacts with RDH11 (PubMed:29410696).
    SequenceCaution:
    • Sequence=AAC15478.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF78966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG31556.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG31557.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAJ18323.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SELENOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELENOF Gene

Post-translational modifications for SELENOF Gene

No data available for DME Specific Peptides for SELENOF Gene

Domains & Families for SELENOF Gene

Gene Families for SELENOF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SELENOF Gene

Graphical View of Domain Structure for InterPro Entry

O60613

UniProtKB/Swiss-Prot:

SEP15_HUMAN :
  • Belongs to the selenoprotein M/F family.
Family:
  • Belongs to the selenoprotein M/F family.
genes like me logo Genes that share domains with SELENOF: view

No data available for Suggested Antigen Peptide Sequences for SELENOF Gene

Function for SELENOF Gene

Molecular function for SELENOF Gene

UniProtKB/Swiss-Prot Function:
May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556).

Phenotypes From GWAS Catalog for SELENOF Gene

Gene Ontology (GO) - Molecular Function for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29410696
genes like me logo Genes that share ontologies with SELENOF: view
genes like me logo Genes that share phenotypes with SELENOF: view

Animal Models for SELENOF Gene

MGI Knock Outs for SELENOF:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELENOF Gene

Localization for SELENOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOF Gene

Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOF gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IDA,IEA 11278576
genes like me logo Genes that share ontologies with SELENOF: view

Pathways & Interactions for SELENOF Gene

PathCards logo

SuperPathways for SELENOF Gene

SuperPathway Contained pathways
1 Folate Metabolism
genes like me logo Genes that share pathways with SELENOF: view

Pathways by source for SELENOF Gene

1 BioSystems pathway for SELENOF Gene

Gene Ontology (GO) - Biological Process for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051084 'de novo' posttranslational protein folding TAS 11278576
genes like me logo Genes that share ontologies with SELENOF: view

No data available for SIGNOR curated interactions for SELENOF Gene

Drugs & Compounds for SELENOF Gene

(2) Drugs for SELENOF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 226
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOF: view

Transcripts for SELENOF Gene

mRNA/cDNA for SELENOF Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOF

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOF Gene

No ASD Table

Relevant External Links for SELENOF Gene

GeneLoc Exon Structure for
SELENOF

Expression for SELENOF Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELENOF

mRNA Expression by UniProt/SwissProt for SELENOF Gene:

O60613-SEP15_HUMAN
Tissue specificity: Higher levels in prostate and thyroid gland.

Evidence on tissue expression from TISSUES for SELENOF Gene

  • Kidney(4.6)
  • Nervous system(4.6)
  • Bone marrow(4.3)
  • Lung(3.5)
  • Intestine(2.9)
  • Pancreas(2.9)
  • Liver(2.8)
  • Thyroid gland(2.8)
  • Adrenal gland(2.1)
  • Blood(2.1)
  • Muscle(2.1)
  • Gall bladder(2)
  • Lymph node(2)
  • Stomach(2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOF Gene

Orthologs for SELENOF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEP15 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SEP15 30
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia SEP15 30
  • 88.48 (n)
mouse
(Mus musculus)
Mammalia Sep15 31 30
  • 87.65 (n)
OneToOne
Selenof 17
rat
(Rattus norvegicus)
Mammalia Sep15 30
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEP15 31 30
  • 79.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 82 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sep15 30
  • 76.03 (n)
zebrafish
(Danio rerio)
Actinopterygii sep15 31 30 30
  • 76.03 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10708 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004986 30
  • 52.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7484 31 30
  • 49.06 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y76B12C.3 31 30
  • 52.68 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05720 30
  • 45.06 (n)
rice
(Oryza sativa)
Liliopsida Os01g0894500 30
  • 47.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Cin.4882 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4882 30
Species where no ortholog for SELENOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOF Gene

ENSEMBL:
Gene Tree for SELENOF (if available)
TreeFam:
Gene Tree for SELENOF (if available)

Paralogs for SELENOF Gene

Paralogs for SELENOF Gene

Pseudogenes.org Pseudogenes for SELENOF Gene

genes like me logo Genes that share paralogs with SELENOF: view

Variants for SELENOF Gene

Additional dbSNP identifiers (rs#s) for SELENOF Gene

Structural Variations from Database of Genomic Variants (DGV) for SELENOF Gene

Variant ID Type Subtype PubMed ID
esv1340746 CNV insertion 17803354
esv3582137 CNV gain 25503493
nsv1777 CNV insertion 18451855
nsv473936 CNV novel sequence insertion 20440878

Additional Variant Information for SELENOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SELENOF Gene

Disorders for SELENOF Gene

Additional Disease Information for SELENOF

No disorders were found for SELENOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOF Gene

Publications for SELENOF Gene

  1. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. (PMID: 10945981) Kumaraswamy E … Gladyshev VN (The Journal of biological chemistry 2000) 2 3 4 54
  2. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. (PMID: 9535873) Gladyshev VN … Hatfield DL (The Journal of biological chemistry 1998) 2 3 4 54
  3. The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism. (PMID: 29410696) Tian J … Ni J (Nutrition & metabolism 2018) 3 4 54
  4. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) Méplan C … Hesketh JE (Carcinogenesis 2010) 3 23 54
  5. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. (PMID: 18239845) Jablonska E … Wasowicz W (European journal of nutrition 2008) 3 23 54

Products for SELENOF Gene

Sources for SELENOF Gene