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This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
SELENBP1 (Selenium Binding Protein 1) is a Protein Coding gene. Diseases associated with SELENBP1 include Extraoral Halitosis Due To Methanethiol Oxidase Deficiency and Posteroinferior Myocardial Infarction. Among its related pathways are IL1 and megakaryocytes in obesity and Metabolism. Gene Ontology (GO) annotations related to this gene include selenium binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008430 | selenium binding | IEA | -- |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0018549 | methanethiol oxidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001650 | fibrillar center | IDA | -- |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005634 | nucleus | IEA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism | ||
2 | Sulfur metabolism | ||
3 | IL1 and megakaryocytes in obesity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015031 | protein transport | IEA | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Selenium | Approved, Investigational, Vet_approved | Pharma | 227 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP20: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP22: | - |
ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: | |||||||||
SP13: | |||||||||
SP14: | |||||||||
SP15: | |||||||||
SP16: | |||||||||
SP17: | |||||||||
SP18: | |||||||||
SP19: | |||||||||
SP20: | |||||||||
SP21: | |||||||||
SP22: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SELENBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SELENBP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SELENBP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Selenbp1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Selenbp2 17 31 |
|
OneToMany | |
Selenbp1 30 17 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | SELENBP1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SELENBP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
SELENBP1 30 31 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | selenbp1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4889 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | selenbp1 30 31 |
|
OneToOne | |
zgc65844 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3726 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011531 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7966 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y37A1B.5 30 |
|
||
Y37A1B.5 31 32 |
|
OneToMany | |||
R11G10.2 31 32 |
|
OneToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SBP3 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1445 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.8462 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0916400 30 |
|
||
Os.8353 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.763 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.22952 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.7068 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2769 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
775140 | Benign: not provided | 151,365,227(-) | C/T | MISSENSE_VARIANT | |
784448 | Benign: not provided | 151,369,198(-) | C/A | INTRON_VARIANT | |
791811 | Benign: not provided | 151,369,195(-) | A/G | INTRON_VARIANT | |
rs1357490520 | Pathogenic: EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY | 151,368,198(-) | C/T | SPLICE_DONOR_VARIANT | |
rs1553204817 | Likely Pathogenic: Extra oral halitosis; EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY | 151,365,568(-) | C/A | NONSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv36n27 | CNV | gain | 19166990 |
dgv53e214 | CNV | gain | 21293372 |
dgv564n54 | CNV | gain | 21841781 |
esv2758969 | CNV | gain | 17122850 |
esv34461 | CNV | gain | 17911159 |
esv3587525 | CNV | gain | 21293372 |
esv3587526 | CNV | loss | 21293372 |
esv3894200 | CNV | gain | 25118596 |
nsv1161560 | CNV | duplication | 26073780 |
nsv438026 | CNV | loss | 16468122 |
nsv441714 | CNV | gain | 18776908 |
nsv470737 | CNV | gain | 18288195 |
nsv522840 | CNV | gain | 19592680 |
nsv818467 | CNV | gain | 17921354 |
nsv824575 | CNV | gain | 20364138 |
nsv831581 | CNV | loss | 17160897 |
nsv8380 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
extraoral halitosis due to methanethiol oxidase deficiency |
|
|
posteroinferior myocardial infarction |
|
|
methionine adenosyltransferase deficiency |
|
|
tyrosinemia |
|
|
schizophrenia |
|
|