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This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be ass... See more...
Aliases for SELENBP1 Gene
Aliases for SELENBP1 Gene
External Ids for SELENBP1 Gene
- HGNC: 10719
- Entrez Gene: 8991
- Ensembl: ENSG00000143416
- OMIM: 604188
- UniProtKB: Q13228
Previous GeneCards Identifiers for SELENBP1 Gene
- GC01M149178
- GC01M147084
- GC01M148111
- GC01M148554
- GC01M148555
- GC01M148149
- GC01M149603
- GC01M151339
- GC01M122714
Summaries for SELENBP1 Gene
-
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for SELENBP1 Gene
SELENBP1 (Selenium Binding Protein 1) is a Protein Coding gene. Diseases associated with SELENBP1 include Extraoral Halitosis Due To Methanethiol Oxidase Deficiency and Posteroinferior Myocardial Infarction. Among its related pathways are IL1 and megakaryocytes in obesity and Metabolism. Gene Ontology (GO) annotations related to this gene include selenium binding.
UniProtKB/Swiss-Prot Summary for SELENBP1 Gene
-
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
Additional gene information for SELENBP1 Gene
- Monarch Initiative
- Search for SELENBP1 at DataMed
- Search for SELENBP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELENBP1 Gene
Genomics for SELENBP1 Gene
GeneHancer (GH) Regulatory Elements for SELENBP1 Gene
Promoters and enhancers for SELENBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SELENBP1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELENBP1
- Top Transcription factor binding sites by QIAGEN in the SELENBP1 gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- CREB
- deltaCREB
- HNF-4alpha1
- HNF-4alpha2
Genomic Locations for SELENBP1 Gene
Genomic Locations for SELENBP1 Gene
- chr1:151,364,302-151,372,734
- (GRCh38/hg38)
- Size:
- 8,433 bases
- Orientation:
- Minus strand
- chr1:151,336,778-151,345,209
- (GRCh37/hg19)
- Size:
- 8,432 bases
- Orientation:
- Minus strand
Genomic View for SELENBP1 Gene
Genes around SELENBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by HGNC
- 1q21.3 by Entrez Gene
- 1q21.3 by Ensembl
SELENBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SELENBP1 Gene
Proteins for SELENBP1 Gene
-
Protein details for SELENBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13228-SBP1_HUMAN
- Recommended name:
- Methanethiol oxidase
- Protein Accession:
- Q13228
- A6NML9
- A6PVW9
- B2RDR3
- B4DKP6
- B4E1F3
- Q49AQ8
- Q96GX7
Protein attributes for SELENBP1 Gene
- Size:
- 472 amino acids
- Molecular mass:
- 52391 Da
- Quaternary structure:
-
- Interacts with USP33.
Protein Expression for SELENBP1 Gene
Post-translational modifications for SELENBP1 Gene
- Phosphorylated.
- The N-terminus is blocked.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SELENBP1 Gene
Antibody Products
- G Biosciences Immunotag™ SELENBP1 Antibody
- NSJ Bioreagents SBP Antibody Selenium Binding Protein
- Creative Diagnostics Anti-SELENBP1 (aa 323-353) polyclonal antibody
- Creative Biolabs Recombinant Anti-Human SELENBP1 Antibody
- Novus Biologicals Antibodies for SELENBP1
- Invitrogen Antibodies for SELENBP1 (AFLGC-SELENBP1)
-
Boster Bio Antibodies for SELENBP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SELENBP1
Protein Products
-
OriGene Purified Proteins for SELENBP1
- Search Origene for MassSpec and Protein Over-expression Lysates for SELENBP1
- Origene Custom Protein Services for SELENBP1
-
Abcam proteins for SELENBP1
Assay Products
- Aviva Systems Biology SELENBP1 ELISA Kit (Human) (OKEH01473) and SELENBP1 ELISA Kit (Human) (OKCD08914)
No data available for DME Specific Peptides for SELENBP1 Gene
Domains & Families for SELENBP1 Gene
Gene Families for SELENBP1 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for SELENBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Selenium binding protein 1 (A6PVW8_HUMAN)
- Selenium binding protein 1 (A6PVX0_HUMAN)
- Selenium binding protein 1 (A6PVX2_HUMAN)
- cDNA FLJ61035, highly similar to Selenium-binding protein 1 (B4E1F3_HUMAN)
- cDNA FLJ13813 fis, clone THYRO1000358, moderately similar to SELENIUM-BINDING LIVER PROTEIN (Q9H8A8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13228- Family:
-
- Belongs to the selenium-binding protein family.
Function for SELENBP1 Gene
Molecular function for SELENBP1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007, ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4; Evidence=. ;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4.8 nM for methanethiol {ECO:0000269 PubMed:29255262};
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by androgen in prostate cancer cells.
- GENATLAS Biochemistry:
- selenium binding protein,56kDa,expressed in heart muscle and other tissues
Enzyme Numbers (IUBMB) for SELENBP1 Gene
Phenotypes From GWAS Catalog for SELENBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008430 | selenium binding | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0018549 | methanethiol oxidase activity | IEA | -- |
Phenotypes for SELENBP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SELENBP1 - Select products 50% OFF >
- * SELENBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SELENBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SELENBP1
- genomics-online: gRNA clones - Search results for available SELENBP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SELENBP1
miRNA for SELENBP1 Gene
- miRTarBase miRNAs that target SELENBP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SELENBP1
- Browse OriGene Inhibitory RNA Products For SELENBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENBP1
- genomics-online: shRNA clones - Search results for available SELENBP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SELENBP1 - Select products 50% OFF >
- * SELENBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SELENBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SELENBP1
- genomics-online: cdna clones - Search results for available SELENBP1 gene related products
- orf clones - Search results for available SELENBP1 gene related products
Cell Line Products
-
Horizon Cell Lines for SELENBP1
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SELENBP1 Gene
Localization for SELENBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SELENBP1 Gene
- Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250 UniProtKB:Q8VIF7}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for SELENBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism | ||
| 2 | Sulfur metabolism | ||
| 3 | IL1 and megakaryocytes in obesity | ||
| 4 | Selenium Metabolism and Selenoproteins | ||
Pathways by source for SELENBP1 Gene
2 BioSystems pathways for SELENBP1 Gene
2 KEGG pathways for SELENBP1 Gene
UniProtKB/Swiss-Prot Q13228-SBP1_HUMAN
- Pathway: Organosulfur degradation.
Interacting Proteins for SELENBP1 Gene
Selected Interacting proteins:
Q13228-SBP1_HUMAN
ENSP00000397261
for SELENBP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SELENBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015031 | protein transport | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for SELENBP1 Gene
Drugs & Compounds for SELENBP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Selenium | Approved, Investigational, Vet_approved | Pharma | 226 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SELENBP1 Gene
mRNA/cDNA for SELENBP1 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368868 1722 bps (ENST00000368868.10)
- ENST00000423070 1887 bps (ENST00000423070.5)
- ENST00000424475 916 bps (ENST00000424475.5)
- ENST00000426705 1928 bps (ENST00000426705.6)
- ENST00000427867 377 bps (ENST00000427867.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SELENBP1 - Select products 50% OFF >
- * SELENBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SELENBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SELENBP1
- genomics-online: gRNA clones - Search results for available SELENBP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SELENBP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SELENBP1
- Browse OriGene Inhibitory RNA Products For SELENBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENBP1
- genomics-online: shRNA clones - Search results for available SELENBP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SELENBP1 - Select products 50% OFF >
- * SELENBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SELENBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SELENBP1
- genomics-online: cdna clones - Search results for available SELENBP1 gene related products
- orf clones - Search results for available SELENBP1 gene related products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - |
| ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: | |||||||||
| SP15: | |||||||||
| SP16: | |||||||||
| SP17: | |||||||||
| SP18: | |||||||||
| SP19: | |||||||||
| SP20: | |||||||||
| SP21: | |||||||||
| SP22: |
Relevant External Links for SELENBP1 Gene
- GeneLoc Exon Structure for
- SELENBP1
Expression for SELENBP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Colon (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Adipose (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for SELENBP1 Gene
This gene is overexpressed in Colon - Transverse (x12.9).
This gene is overexpressed in Liver, secretome (8.0) and Nasal epithelium (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SELENBP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELENBP1
SOURCE GeneReport for Unigene cluster for SELENBP1 Gene:
Hs.632460mRNA Expression by UniProt/SwissProt for SELENBP1 Gene:
Q13228-SBP1_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.
Evidence on tissue expression from TISSUES for SELENBP1 Gene
- Intestine(4.9)
- Nervous system(4.9)
- Liver(4.7)
- Lung(4.7)
- Heart(4.6)
- Blood(3.6)
- Kidney(2.7)
- Muscle(2.4)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for SELENBP1
-
OriGene qPCR primer pairs and template standards for SELENBP1
- genomics-online: primer clones - Search results for available SELENBP1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENBP1 Gene
Orthologs for SELENBP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SELENBP1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SELENBP1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SELENBP1 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Selenbp1 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Selenbp2 17 31 |
|
||
| Selenbp1 31 30 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | SELENBP1 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SELENBP1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| SELENBP1 31 31 30 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | selenbp1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4889 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | selenbp1 31 30 |
|
OneToOne | |
| zgc65844 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3726 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011531 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7966 31 32 30 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y37A1B.5 30 |
|
||
| Y37A1B.5 31 32 |
|
OneToMany | |||
| R11G10.2 31 32 |
|
OneToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SBP3 30 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.8462 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1445 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0916400 30 |
|
||
| Os.8353 30 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.763 30 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.22952 30 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.7068 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Cin.2769 30 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2769 30 |
|
- Species where no ortholog for SELENBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for SELENBP1 Gene
- ENSEMBL:
- Gene Tree for SELENBP1 (if available)
- TreeFam:
- Gene Tree for SELENBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SELENBP1: view image
Paralogs for SELENBP1 Gene
(1) SIMAP similar genes for SELENBP1 Gene using alignment to 9 proteins:
- SBP1_HUMAN
- A6PVW9_HUMAN
- A6PVX1_HUMAN
- C9JVL0_HUMAN
- F2Z2W8_HUMAN
- F8WBA9_HUMAN
- F8WCR4_HUMAN
- H0Y532_HUMAN
- Q9H8A8_HUMAN
No data available for Paralogs for SELENBP1 Gene
Variants for SELENBP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELENBP1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 775140 | Benign: not provided | 151,365,227(-) | C/T | MISSENSE_VARIANT | |
| 784448 | Benign: not provided | 151,369,198(-) | C/A | INTRON_VARIANT | |
| 791811 | Benign: not provided | 151,369,195(-) | A/G | INTRON_VARIANT | |
| rs1357490520 | Pathogenic: EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY | 151,368,198(-) | C/T | SPLICE_DONOR_VARIANT | |
| rs1553204817 | Likely Pathogenic: Extra oral halitosis; EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY | 151,365,568(-) | C/A | NONSENSE |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv36n27 | CNV | gain | 19166990 |
| dgv53e214 | CNV | gain | 21293372 |
| dgv564n54 | CNV | gain | 21841781 |
| esv2758969 | CNV | gain | 17122850 |
| esv34461 | CNV | gain | 17911159 |
| esv3587525 | CNV | gain | 21293372 |
| esv3587526 | CNV | loss | 21293372 |
| esv3894200 | CNV | gain | 25118596 |
| nsv1161560 | CNV | duplication | 26073780 |
| nsv438026 | CNV | loss | 16468122 |
| nsv441714 | CNV | gain | 18776908 |
| nsv470737 | CNV | gain | 18288195 |
| nsv522840 | CNV | gain | 19592680 |
| nsv818467 | CNV | gain | 17921354 |
| nsv824575 | CNV | gain | 20364138 |
| nsv831581 | CNV | loss | 17160897 |
| nsv8380 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.28;
53.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SELENBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SELENBP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENBP1 Gene
Disorders for SELENBP1 Gene
(7) MalaCards diseases for SELENBP1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| extraoral halitosis due to methanethiol oxidase deficiency |
|
|
| posteroinferior myocardial infarction |
|
|
| methionine adenosyltransferase deficiency |
|
|
| tyrosinemia |
|
|
| schizophrenia |
|
|
Search SELENBP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SBP1_HUMAN- Extraoral halitosis due to methanethiol oxidase deficiency (EHMTO) [MIM:618148]: An autosomal recessive malodor condition characterized by extraoral blood-borne halitosis resulting from the accumulation of sulfur-containing metabolites. In extraoral blood-borne halitosis, malodorant compounds are carried to the lungs, where they enter the breath. Affected individuals have a cabbage-like breath odor, high levels of methanethiol and dimethylsulfide in oral and nasal breath, and elevated urinary excretion of dimethylsulfoxide in the absence of intake of dimethylsulfide-containing food or use of sulfur-containing medication, lower-gastrointestinal problems, and known metabolic defects, such as methionine adenosyltransferase deficiency and tyrosinemia. {ECO:0000269 PubMed:29255262}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SELENBP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for SELENBP1 Gene
Publications for SELENBP1 Gene
- Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PMID: 19118533) Jeong JY … Sytkowski AJ (Biochemical and biophysical research communications 2009) 3 4 23 54
- Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PMID: 16645984) Kim H … Kim H (Proteomics 2006) 3 4 23 54
- Selenium binding protein 1 in ovarian cancer. (PMID: 16380993) Huang KC … Ng SW (International journal of cancer 2006) 3 4 23 54
- Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PMID: 9027582) Chang PW … Fung KP (Journal of cellular biochemistry 1997) 2 3 4 54
- Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. (PMID: 29255262) Pol A … Wevers RA (Nature genetics 2018) 3 4 54
ExternalLinks
Products for SELENBP1 Gene
- Custom Antibody ServicesOriGene Antibodies for SELENBP1
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- VectorBuilder Stable cell line generation for SELENBP1
- antibodies-online: Show 34 available SELENBP1 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SELENBP1
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- Santa Cruz Biotechnology (SCBT) CRISPR for SELENBP1
- Horizon Cell Lines for SELENBP1
- genomics-online: cdna clones - Search results for available SELENBP1 gene related products
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- genomics-online: gRNA clones - Search results for available SELENBP1 gene related products
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- Boster Bio Antibodies for SELENBP1
- Browse Boster Bio ELISA Kits
Sources for SELENBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
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- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
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- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
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- (99) ProteomicsDB
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- (105) diseasecard
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