Aliases for SELE Gene
External Ids for SELE Gene
Previous HGNC Symbols for SELE Gene
Previous GeneCards Identifiers for SELE Gene
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SELE Gene
SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include Leukocyte Adhesion Deficiency, Type I and Rheumatoid Vasculitis. Among its related pathways are Cell surface interactions at the vascular wall and Cell adhesion_Cell-matrix glycoconjugates. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and phospholipase binding. An important paralog of this gene is SELP.
UniProtKB/Swiss-Prot Summary for SELE Gene
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.