The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that ... See more...

Aliases for SELE Gene

Aliases for SELE Gene

  • Selectin E 2 3 5
  • Endothelial Leukocyte Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member E 3 4
  • Endothelial Adhesion Molecule 1 2 3
  • E-Selectin 3 4
  • LECAM2 3 4
  • ELAM-1 3 4
  • CD62E 2 3
  • ELAM1 3 4
  • ESEL 2 3
  • Leukocyte Endothelial Cell Adhesion Molecule 2 3
  • Leukocyte-Endothelial Cell Adhesion Molecule 2 4
  • CD62E Antigen 4
  • ELAM 3
  • SELE 5

External Ids for SELE Gene

Previous HGNC Symbols for SELE Gene

  • ELAM1
  • ELAM

Previous GeneCards Identifiers for SELE Gene

  • GC01M167320
  • GC01M165342
  • GC01M166181
  • GC01M166671
  • GC01M166879
  • GC01M166423
  • GC01M167958
  • GC01M169691
  • GC01M140914

Summaries for SELE Gene

Entrez Gene Summary for SELE Gene

  • The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELE Gene

SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include Rheumatoid Vasculitis and African Tick-Bite Fever. Among its related pathways are Cell surface interactions at the vascular wall and ATF-2 transcription factor network. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and phospholipase binding. An important paralog of this gene is SELP.

UniProtKB/Swiss-Prot Summary for SELE Gene

  • Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

Tocris Summary for SELE Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for SELE Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELE Gene

Genomics for SELE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SELE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J169734 Promoter 0.3 EPDnew 250.3 +30.6 30606 0.1 lnc-SELL-1 SELE HSALNG0008351 SELL C1orf112
GH01J169571 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.7 +192.4 192372 1.6 SSRP1 CEBPA HOMEZ THAP11 FOXA2 SMAD4 RXRA SAP130 MIER3 RARA F5 C1orf112 METTL18 SELE SCYL3 piR-38351-028 SLC19A2
GH01J169600 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 +156.2 156173 15.3 ZNF654 CEBPA CTCF REST CEBPB TRIM22 EP300 RAD21 SMC3 ZFP91 METTL18 F5 SELP C1orf112 SELE SELL lnc-F5-1
GH01J169565 Enhancer 0.9 Ensembl ENCODE 10.4 +198.7 198704 1.2 CEBPA CEBPB KLF11 FEZF1 HOMEZ FOXA2 ZNF511 ETV4 RARA ZSCAN9 SELE CCDC181 F5 piR-38351-028 SLC19A2
GH01J169546 Enhancer 0.7 ENCODE 10 +218.3 218257 0 YY1 CTCF REST TRIM22 ZNF217 RFX5 SMC3 JUND RAD21 ZNF2 piR-38351-028 SLC19A2 ENSG00000213062 F5 CCDC181 SELE HSALNG0008343
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELE

Top Transcription factor binding sites by QIAGEN in the SELE gene promoter:
  • CREB
  • GR
  • GR-alpha
  • GR-beta
  • STAT3

Genomic Locations for SELE Gene

Latest Assembly
chr1:169,722,640-169,764,705
(GRCh38/hg38)
Size:
42,066 bases
Orientation:
Minus strand

Previous Assembly
chr1:169,691,781-169,703,220
(GRCh37/hg19 by Entrez Gene)
Size:
11,440 bases
Orientation:
Minus strand

chr1:169,691,781-169,733,846
(GRCh37/hg19 by Ensembl)
Size:
42,066 bases
Orientation:
Minus strand

Genomic View for SELE Gene

Genes around SELE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELE Gene

Proteins for SELE Gene

  • Protein details for SELE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16581-LYAM2_HUMAN
    Recommended name:
    E-selectin
    Protein Accession:
    P16581
    Secondary Accessions:
    • A2RRD6
    • P16111

    Protein attributes for SELE Gene

    Size:
    610 amino acids
    Molecular mass:
    66655 Da
    Quaternary structure:
    • Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.

    Three dimensional structures from OCA and Proteopedia for SELE Gene

neXtProt entry for SELE Gene

Post-translational modifications for SELE Gene

  • Glycosylation at Asn25, Asn145, Asn160, Asn179, Asn199, Asn203, Asn265, Asn312, Asn332, Asn503, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for SELE Gene

Antibodies for research

  • Abcam antibodies for SELE

No data available for DME Specific Peptides for SELE Gene

Domains & Families for SELE Gene

Gene Families for SELE Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SELE Gene

InterPro:
Blocks:
  • Type I EGF
  • Sushi domain/SCR domain/CCP module
  • Selectin superfamily complement-binding repeat signature

Suggested Antigen Peptide Sequences for SELE Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte-endothelial cell adhesion molecule 2 (LYAM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16581

UniProtKB/Swiss-Prot:

LYAM2_HUMAN :
  • Belongs to the selectin/LECAM family.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELE: view

Function for SELE Gene

Molecular function for SELE Gene

UniProtKB/Swiss-Prot Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
GENATLAS Biochemistry:
E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations of the gene may be a risk factor in atherosclerosis

Phenotypes From GWAS Catalog for SELE Gene

Gene Ontology (GO) - Molecular Function for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 12960351
GO:0005515 protein binding IPI 18606703
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IDA 7680663
GO:0043274 phospholipase binding IDA 12960351
genes like me logo Genes that share ontologies with SELE: view
genes like me logo Genes that share phenotypes with SELE: view

Animal Models for SELE Gene

MGI Knock Outs for SELE:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELE

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELE Gene

Localization for SELE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELE Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELE gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 4
nucleus 3
cytosol 3
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA 28011641
GO:0005901 caveola IDA 12960351
GO:0005905 clathrin-coated pit IDA 18029551
genes like me logo Genes that share ontologies with SELE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELE Gene

Pathways & Interactions for SELE Gene

genes like me logo Genes that share pathways with SELE: view

Pathways by source for SELE Gene

SIGNOR curated interactions for SELE Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 9312078
GO:0002523 leukocyte migration involved in inflammatory response TAS 18029551
GO:0006954 inflammatory response TAS 2466335
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18029551
genes like me logo Genes that share ontologies with SELE: view

Drugs & Compounds for SELE Gene

(89) Drugs for SELE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Target, inhibitor 207
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1763
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2449
leucovorin Approved Pharma 1627
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 2071

(65) Additional Compounds for SELE Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
Heparin sodium salt
9041-08-1
KF 38789
257292-29-8
PM 102
1234564-95-4

(5) Tocris Compounds for SELE Gene

Compound Action Cas Number
Ac2-12 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 256447-08-2
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
Heparin sodium salt Anticoagulant 9041-08-1
KF 38789 Selective inhibitor of P-selectin-mediated cell adhesion 257292-29-8
PM 102 Antagonist of heparin (Cat. No. 2812) 1234564-95-4

(2) ApexBio Compounds for SELE Gene

Compound Action Cas Number
A 205804 E-selectin/ICAM-1 expression inhibitor 251992-66-2
Thiolutin RNA polymerase inhibitor,antibiotic 1987-11-6
genes like me logo Genes that share compounds with SELE: view

Transcripts for SELE Gene

mRNA/cDNA for SELE Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELE

Alternative Splicing Database (ASD) splice patterns (SP) for SELE Gene

No ASD Table

Relevant External Links for SELE Gene

GeneLoc Exon Structure for
SELE

Expression for SELE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SELE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELE Gene

This gene is overexpressed in Fallopian Tube (x8.9) and Adipose - Visceral (Omentum) (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELE

SOURCE GeneReport for Unigene cluster for SELE Gene:

Hs.82848

Evidence on tissue expression from TISSUES for SELE Gene

  • Heart(4.7)
  • Liver(3.5)
  • Blood(3.1)
  • Nervous system(2.9)
  • Intestine(2.8)
  • Bone marrow(2.6)
  • Skin(2.6)
  • Lung(2.6)
  • Kidney(2.5)
  • Lymph node(2.5)
  • Muscle(2.4)
  • Spleen(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with SELE: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELE Gene

Orthologs for SELE Gene

This gene was present in the common ancestor of animals.

Orthologs for SELE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SELE 29 30
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SELE 29 30
  • 81.2 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sele 29 16 30
  • 77.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sele 29
  • 74.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia SELE 30
  • 63 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SELE 30
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SELE 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SELE 29 30
  • 57.98 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii selp 30
  • 28 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta hig 30
  • 10 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T07H6.4 30
  • 12 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10017 30
  • 21 (a)
ManyToMany
-- 30
  • 12 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
-- 30
  • 9 (a)
ManyToMany
CSA.10029 30
  • 8 (a)
ManyToMany
-- 30
  • 7 (a)
ManyToMany
-- 30
  • 7 (a)
ManyToMany
Species where no ortholog for SELE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SELE Gene

ENSEMBL:
Gene Tree for SELE (if available)
TreeFam:
Gene Tree for SELE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SELE: view image
Alliance of Genome Resources:
Additional Orthologs for SELE

Paralogs for SELE Gene

(2) SIMAP similar genes for SELE Gene using alignment to 6 proteins:

  • LYAM2_HUMAN
  • Q5TI72_HUMAN
  • Q5TI73_HUMAN
  • Q5TI74_HUMAN
  • Q5TI75_HUMAN
  • V9GYI4_HUMAN
genes like me logo Genes that share paralogs with SELE: view

Variants for SELE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SELE Gene

LYAM2_HUMAN-P16581
A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELE Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs141518098 Benign: not provided 169,728,127(-) A/G
NM_000450.2(SELE):c.1210T>C (p.Leu404=)
SYNONYMOUS
rs3917429 Uncertain Significance: not provided 169,726,804(-) G/Ap.Pro550Ser
NM_000450.2(SELE):c.1648C>T (p.Pro550Ser)
MISSENSE
rs3917455 Benign: not provided 169,729,516(-) A/G
NM_000450.2(SELE):c.873T>C (p.Asn291=)
SYNONYMOUS
rs41272475 Likely Benign: not provided 169,729,502(-) T/G
NM_000450.2(SELE):c.887A>C (p.Lys296Thr)
MISSENSE
rs5364 Benign: not provided 169,729,506(-) C/Tp.Glu295Lys
NM_000450.2(SELE):c.883G>A (p.Glu295Lys)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SELE Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SELE Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for SELE Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELE Gene

Human Gene Mutation Database (HGMD)
SELE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELE
Leiden Open Variation Database (LOVD)
SELE

SNP Genotyping and Copy Number Assays for research

Disorders for SELE Gene

MalaCards: The human disease database

(105) MalaCards diseases for SELE Gene - From: COP and GCD

Disorder Aliases PubMed IDs
rheumatoid vasculitis
african tick-bite fever
  • rickettsia africae spotted fever
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
leukocyte adhesion deficiency, type i
  • lad
peripheral vascular disease
  • arterial occlusive disease
- elite association - COSMIC cancer census association via MalaCards
Search SELE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SELE

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SELE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELE Gene

Publications for SELE Gene

  1. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. (PMID: 19212205) Khazen D … Ayed K (European journal of gastroenterology & hepatology 2009) 3 22 40
  2. E-selectin and L-selectin polymorphisms in patients with periodontitis. (PMID: 18973547) Houshmand B … Gholami L (Journal of periodontal research 2009) 3 22 40
  3. The common variants of E-selectin gene in Graves' disease. (PMID: 18094708) Chen H … Ning G (Genes and immunity 2008) 3 22 40
  4. Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (PMID: 17036337) Carmichael SL … Lammer EJ (American journal of medical genetics. Part A 2006) 3 22 40
  5. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. (PMID: 16820586) Podgoreanu MV … Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team (Circulation 2006) 3 22 40

Products for SELE Gene

  • Addgene plasmids for SELE

Sources for SELE Gene