Aliases for SEL1L Gene
- SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase 2 3 5
- SEL1L, ERAD E3 Ligase Adaptor Subunit 2 3
- Suppressor Of Lin-12-Like Protein 1 3 4
- Protein Sel-1 Homolog 1 3 4
- Suppressor Of Lin 12 (Sel-1), C. Elegans, Homolog Of 3
- Sel-1 Suppressor Of Lin-12-Like 1 (C. Elegans) 2
- Sel-1 Suppressor Of Lin-12-Like (C. Elegans) 2
External Ids for SEL1L Gene
Previous GeneCards Identifiers for SEL1L Gene
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SEL1L Gene
SEL1L (SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase) is a Protein Coding gene. Diseases associated with SEL1L include Type 1 Diabetes Mellitus 11 and Granular Corneal Dystrophy. Among its related pathways are Metabolism of proteins and Calnexin/calreticulin cycle. An important paralog of this gene is SEL1L2.
UniProtKB/Swiss-Prot Summary for SEL1L Gene
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.