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Aliases for SECISBP2L Gene

Aliases for SECISBP2L Gene

  • SECIS Binding Protein 2 Like 2 3 5
  • Selenocysteine Insertion Sequence-Binding Protein 2-Like 3
  • SECIS-Binding Protein 2-Like 4
  • KIAA0256 4
  • SBP2L 3
  • SLAN 3

External Ids for SECISBP2L Gene

Previous GeneCards Identifiers for SECISBP2L Gene

  • GC15M047069
  • GC15M049280
  • GC15M026112

Summaries for SECISBP2L Gene

GeneCards Summary for SECISBP2L Gene

SECISBP2L (SECIS Binding Protein 2 Like) is a Protein Coding gene. An important paralog of this gene is SECISBP2.

UniProtKB/Swiss-Prot for SECISBP2L Gene

  • Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

Additional gene information for SECISBP2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECISBP2L Gene

Genomics for SECISBP2L Gene

GeneHancer (GH) Regulatory Elements for SECISBP2L Gene

Promoters and enhancers for SECISBP2L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I049044 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.8 +0.8 750 2.8 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 SECISBP2L DTWD1 CEP152 DUT SHC4 ENSG00000259488 RN7SL577P
GH15I049421 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -377.7 -377710 4.7 CTCF RB1 ARNT ZSCAN4 ASH1L ZNF2 DNMT3B RAD21 CHAMP1 CC2D1A FGF7 DTWD1 COPS2 ENSG00000259715 SECISBP2L GALK2 LOC105370811 FAM227B
GH15I049169 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -124.4 -124374 3.4 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 GALK2 MIR4716 SECISBP2L FGF7 FAM227B RPL15P19
GH15I049154 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -109.1 -109105 3.1 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 COPS2 GALK2 NDUFAF4P1 DTWD1 DUT ENSG00000259488 CEP152 FGF7 SECISBP2L FAM227B
GH15I049133 Enhancer 0.9 Ensembl ENCODE 10.8 -90.0 -90012 5.2 MXI1 JUN ZBTB40 BRCA1 RFX5 POLR2A SCRT2 RCOR1 FOSL2 FOS ENSG00000200120 GC15M049139 SECISBP2L SHC4 FGF7 GALK2 FAM227B COPS2 GC15M049107
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SECISBP2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SECISBP2L gene promoter:

Genomic Locations for SECISBP2L Gene

Genomic Locations for SECISBP2L Gene
58,088 bases
Minus strand

Genomic View for SECISBP2L Gene

Genes around SECISBP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SECISBP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SECISBP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECISBP2L Gene

Proteins for SECISBP2L Gene

  • Protein details for SECISBP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenocysteine insertion sequence-binding protein 2-like
    Protein Accession:
    Secondary Accessions:
    • Q8N767

    Protein attributes for SECISBP2L Gene

    1101 amino acids
    Molecular mass:
    121776 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13386.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SECISBP2L Gene


neXtProt entry for SECISBP2L Gene

Post-translational modifications for SECISBP2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SECISBP2L Gene

No data available for DME Specific Peptides for SECISBP2L Gene

Domains & Families for SECISBP2L Gene

Gene Families for SECISBP2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SECISBP2L Gene

Suggested Antigen Peptide Sequences for SECISBP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SECISBP2L: view

No data available for UniProtKB/Swiss-Prot for SECISBP2L Gene

Function for SECISBP2L Gene

Molecular function for SECISBP2L Gene

UniProtKB/Swiss-Prot Function:
Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

Phenotypes From GWAS Catalog for SECISBP2L Gene

Gene Ontology (GO) - Molecular Function for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0035368 selenocysteine insertion sequence binding IBA --
GO:0043021 ribonucleoprotein complex binding IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view
genes like me logo Genes that share phenotypes with SECISBP2L: view

Animal Model Products

CRISPR Products

miRNA for SECISBP2L Gene

miRTarBase miRNAs that target SECISBP2L

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SECISBP2L Gene

Localization for SECISBP2L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SECISBP2L gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030529 intracellular ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SECISBP2L Gene

Pathways & Interactions for SECISBP2L Gene

SuperPathways for SECISBP2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view

No data available for Pathways by source and SIGNOR curated interactions for SECISBP2L Gene

Drugs & Compounds for SECISBP2L Gene

No Compound Related Data Available

Transcripts for SECISBP2L Gene

Unigene Clusters for SECISBP2L Gene

SECIS binding protein 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2L Gene

No ASD Table

Relevant External Links for SECISBP2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SECISBP2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SECISBP2L Gene

mRNA differential expression in normal tissues according to GTEx for SECISBP2L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for SECISBP2L Gene

This gene is overexpressed in Plasma (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SECISBP2L Gene

Protein tissue co-expression partners for SECISBP2L Gene

NURSA nuclear receptor signaling pathways regulating expression of SECISBP2L Gene:


SOURCE GeneReport for Unigene cluster for SECISBP2L Gene:


Evidence on tissue expression from TISSUES for SECISBP2L Gene

  • Nervous system(3.5)
  • Spleen(2.8)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with SECISBP2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SECISBP2L Gene

Orthologs for SECISBP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for SECISBP2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SECISBP2L 33 34
  • 99.76 (n)
(Canis familiaris)
Mammalia SECISBP2L 33 34
  • 93.77 (n)
(Rattus norvegicus)
Mammalia Secisbp2l 33
  • 85.45 (n)
(Mus musculus)
Mammalia Secisbp2l 33 16 34
  • 84.97 (n)
(Monodelphis domestica)
Mammalia SECISBP2L 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SECISBP2L 34
  • 70 (a)
(Bos Taurus)
Mammalia SECISBP2L 34
  • 50 (a)
(Gallus gallus)
Aves SECISBP2L 33 34
  • 78.75 (n)
(Anolis carolinensis)
Reptilia SECISBP2L 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia secisbp2l 33
  • 70.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13483 33
(Danio rerio)
Actinopterygii secisbp2l 33
  • 61.21 (n)
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sbp2 34
  • 30 (a)
Species where no ortholog for SECISBP2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SECISBP2L Gene

Gene Tree for SECISBP2L (if available)
Gene Tree for SECISBP2L (if available)

Paralogs for SECISBP2L Gene

Paralogs for SECISBP2L Gene

(2) SIMAP similar genes for SECISBP2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SECISBP2L: view

Variants for SECISBP2L Gene

Sequence variations from dbSNP and Humsavar for SECISBP2L Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000083169 -- 49,000,806(-) C/T intron_variant
rs1000096902 -- 49,004,253(-) G/C intron_variant
rs1000112441 -- 49,045,869(-) T/C intron_variant
rs1000122052 -- 49,009,400(-) G/A intron_variant
rs1000177063 -- 49,034,743(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SECISBP2L Gene

Variant ID Type Subtype PubMed ID
nsv476989 CNV novel sequence insertion 20440878
nsv952622 CNV duplication 24416366

Variation tolerance for SECISBP2L Gene

Residual Variation Intolerance Score: 7.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SECISBP2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SECISBP2L Gene

Disorders for SECISBP2L Gene

Additional Disease Information for SECISBP2L

No disorders were found for SECISBP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SECISBP2L Gene

Publications for SECISBP2L Gene

  1. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. (PMID: 22530054) Donovan J … Copeland PR (PloS one 2012) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for SECISBP2L Gene

Sources for SECISBP2L Gene

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