Aliases for SECISBP2 Gene
External Ids for SECISBP2 Gene
Previous GeneCards Identifiers for SECISBP2 Gene
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
GeneCards Summary for SECISBP2 Gene
SECISBP2 (SECIS Binding Protein 2) is a Protein Coding gene. Diseases associated with SECISBP2 include Thyroid Hormone Metabolism, Abnormal and Pontocerebellar Hypoplasia, Type 2D. Among its related pathways are Viral mRNA Translation and Selenium Metabolism and Selenoproteins. Gene Ontology (GO) annotations related to this gene include ribonucleoprotein complex binding. An important paralog of this gene is SECISBP2L.
UniProtKB/Swiss-Prot Summary for SECISBP2 Gene
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.