Aliases for SEC63 Gene
External Ids for SEC63 Gene
Previous GeneCards Identifiers for SEC63 Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC63 Gene
SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease 2 With Or Without Kidney Cysts and Polycystic Liver Disease 1 With Or Without Kidney Cysts. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins.
UniProtKB/Swiss-Prot Summary for SEC63 Gene
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).